Results 71 to 80 of about 1,976 (187)

Rapid Determination of Association Constants using Routine Plate Reader Measurements

Analysis &Sensing, Volume 6, Issue 1, January 2026.
A high‐throughput plate reader method enables rapid, accurate determination of host–guest binding constants and limits of detection using standard laboratory equipment. The approach is validated across diverse systems and supports machine learning regression, offering a robust analytical tool for supramolecular sensing and quantitative analysis. Though
Austin R. Sartori, Anjusha Prakash, Elnaz Safari, Mikhail Zamkov, Pavel Anzenbacher Jr   +4 more
wiley   +1 more source

Synthesis , Antibacterial Activity of Sm(III) Complex With L-phenylalanine

Zanco Journal of Pure and Applied Sciences, 2022
      Samarium–amino acid complex in aqueous solution was synthesized in formula:[Sm(phen)3].H2O, by reaction of  L-phenylalanine (phen) with samarium chloride hexahydrate (SmCl3.6H2O) in (1:3) M:L mole ratio .
Kamaran Basheer Hussein
doaj  

Activity Profiling of Nitro‐Substituted Di(Hetero)Aryl 1,3,4‐ and 1,2,4‐Oxadiazoles: Antimicrobial, Cholinesterase Inhibition and Antioxidant Potential

Archiv der Pharmazie, Volume 359, Issue 1, January 2026.
Novel nitro‐substituted diaryl 1,3,4‐ and 1,2,4‐oxadiazoles were synthesised via molecular hybridisation of bioactive heterocycles. Selected derivatives exhibited potent antimicrobial activity, including against Mycobacterium tuberculosis and Staphylococcus aureus, and cholinesterase inhibitory activity, with promising selectivity.
Enikő Šikorová, Šárka Štěpánková, Eva Frýbová, Klára Konečná, Jana Korbielová, Markéta Švarcová, Ondřej Janďourek, Václav Pflégr, Szilvia Bősze, Martin Krátký   +9 more
wiley   +1 more source

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source

A mild and efficient method for the preparation of 3-(2'-Aminoaryl)pyrazoles from 4-chloroquinolines [PDF]

, 2007
We describe a mild and efficient method for the formation of 3-(2'-aminoaryl)pyrazoles in excellent yields from reactions of 4-chloroquinolines with hydrazine.
Alice M. R. Bernardino, Cesar D. de Oliveira, James L. Wardell, Julio C. Borges, Luiz C. da Silva Pinheiro, Misbahul Ain Khan, Roberta K. F. Marra, Solange M. S. V. Wardell   +7 more
core   +1 more source

Exploiting Pharmacokinetic/Pharmacodynamic Methods for Optimizing and Accelerating Drug Development of Innovative Anti‐Infectives

ChemMedChem, Volume 21, Issue 2, January 2026.
This article focuses on the interplay of absorbed, distributed, metabolized, and excreted (ADME) properties; in vivo pharmacokinetics (PK); and pharmacodynamics (PD) supported by in silico PK/PD modeling techniques to improve drug development by acceleration of processes and reducing attrition risks.
Katharina Rox
wiley   +1 more source

Karyotyping and Distribution Patterns of Endemic Chinese Lilies: Insights Into Their Conservation Under Climate Change

Ecology and Evolution, Volume 16, Issue 1, January 2026.
This study integrates cytogenetic and ecological analyses of two endemic Chinese alpine lilies, Lilium lophophorum (2n = 24) and L. nanum (2n = 48), to establish a foundational understanding of their chromosomal diversity and distribution patterns. We document substantial intraspecific karyotypic variation in diploid L.
Tengfei Gui, Mingyue Lin, Zhiming Li, Deli Peng, Yuan Huang, Wenguang Sun   +5 more
wiley   +1 more source

8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications

Drug Design, Development and Therapy, 2013
Veda Prachayasittikul,1 Supaluk Prachayasittikul,2 Somsak Ruchirawat,3 Virapong Prachayasittikul11Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, 2Center of Data Mining and Biomedical Informatics, Faculty of ...
Prachayasittikul V, Prachayasittikul S, Ruchirawat S, Prachayasittikul V   +3 more
doaj  

PH and Electrochemical Responsive Materials for Corrosion Smart Coating Applications [PDF]

, 2008
Corrosion is a costly issue for military operations and civil industries. While most corrosion initiates from localized corrosion form, such as pitting, failure directly caused by localized corrosion is the most dangerous kind, because it is difficult to
Calle, Luz M., Li, Wenyan
core   +1 more source

Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases [PDF]

, 2015
Age-associated neurodegenerative disorders such as Alzheimer’s disease are a major public health challenge, due to the demographic increase in the proportion of older individuals in society.
A Gutierrez-Zepeda, A Hornsten, A Lublin, A Murakami, A Tauffenberger, A Teixeira-Castro, A Teixeira-Castro, A Vaccaro, Alan Morgan, AR Burns, AV McCormick, B Lakowski, B Wolozin, BA Benitez, BB Kautu, BC Kraemer, BH Shin, BP Hubbard, C Fatouros, C Frokjaer-Jensen, C Soto, C Voisine, C Yao, CD Link, CD Link, CD Link, CD Link, CI Nussbaum-Krammer, CJ Locke, CY Ewald, D Levitan, DC Swinney, DC Swinney, DE Ehrnhoefer, DF Silva, DF Tardiff, DP Karpinar, DS Fay, E Braungart, EM Mandelkow, F Aparecida Paiva, F Cabreiro, F-X Lejeune, G McColl, G Pani, H Varma, H Wang, H Witan, HR Brignull, HV McCue, J Drake, J Li, J Liu, J Parker, J Parker, J Sämann, J Wang, JA Baur, JA Hardaway, Jeff W. Barclay, JF Morley, JN Sleigh, JP Taylor, JS Sangha, JV Smith, JW Barclay, K Evason, K Yamanaka, K-W Park, KA Caldwell, KE Matlack, L Diomede, L Diomede, L Noskova, L Xiao, LE Dosanjh, LS Schneider, M Briese, M Cadieux-Dion, M Haltia, M Haltia, M Lakso, M Marvanova, M Velinov, ML Florez-McClure, N Bizat, N Bizat, N Wittenburg, NF Liachko, NF Liachko, NT Christie, P Haldimann, PE Ash, PJ Muchowski, PW Faber, Q Ruan, R Brandt, R Keowkase, R Nass, R Nass, R Ved, R-H Fu, R-H Fu, RA Weiss, RD Burgoyne, Robert D. Burgoyne, S Abbas, S Abbas, S Alavez, S Amor, S Ayyadevara, S Buttner, S Cao, S Hamamichi, S Jagota, S Saha, S Treusch, SH Satyal, SJ Park, SM Yatin, SS Karuppagounder, SS Kashyap, T Gidalevitz, T Ham van, T Kuwahara, T Kuwahara, T Kuwahara, T Miyasaka, T Oeda, T Zhang, TJ Ham van, TT Ching, U Arya, V Crunelli, V Dostal, W Springer, X Chen, X Chen, X Yang, Xi Chen, Y Wu, Z Liu   +141 more
core   +1 more source