A Simple Procedure for Synthesis of Biological Active 4-oxo-4-(quinolin-8-yloxy)but-2-enoic acid [PDF]
Eurasian Chemico-Technological Journal, 2022 The article is devoted to research on the synthesis of hydroxyquinoline derivative based on 8-oxyquinoline and maleic anhydride. Analysis of available literature was carried out, some drugs were found that are produced based on hydroxyquinoline ...
V.V. Merkulov +4 more
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Structure–Activity Relationships and Transcriptomic Analysis of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors [PDF]
Antioxidants, 2022 To evaluate the differences in action of commercially available 2-oxoglutarate mimetics and “branched-tail” oxyquinoline inhibitors of hypoxia-inducible factor prolyl hydroxylase (HIF PHD), the inhibitors’ IC50 values in the activation of HIF1 ODD ...
Andrey A. Poloznikov +17 more
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Hypoxia-Induced miR-148a Downregulation Contributes to Poor Survival in Colorectal Cancer [PDF]
Frontiers in Genetics, 2021 Hypoxia is an extensively investigated condition due to its contribution to various pathophysiological processes including cancer progression and metastasis formation.
Stepan Nersisyan +4 more
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A Novel Approach To Identify Inhibitors of Iron Acquisition Systems of Pseudomonas aeruginosa [PDF]
Microbiology Spectrum, 2022 Pseudomonas aeruginosa is an opportunistic pathogen that has been declared by the World Health Organization as a “priority 1 critical pathogen” needing immediate new strategies for chemotherapy. During infection, P.
Mamie Kannon +5 more
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HIF-Dependent NFATC1 Activation Upregulates ITGA5 and PLAUR in Intestinal Epithelium in Inflammatory Bowel Disease [PDF]
Frontiers in Genetics, 2021 Intestinal epithelial cells exist in physiological hypoxia, leading to hypoxia-inducible factor (HIF) activation and supporting barrier function and cell metabolism of the intestinal epithelium.
Evgeny Knyazev +5 more
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High-Resolution Splenic Imaging: [68Ga]Ga-Oxine Red Blood Cell PET/CT for Differentiation of Splenosis Mimicking Malignant Lymphoma [PDF]
Tomography, 2022 The differentiation of splenic tissue from malignant lesions via imaging may be challenging, particularly considering aberrant or accessory lesions and diseases that are rarely encountered.
Anke Werner +2 more
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Determination of iron in natural and mineral waters by flame atomic absorption spectrometry [PDF]
Journal of the Serbian Chemical Society, 2004 Simple methods for the determination of Fe in natural and mineral waters by flame atomic absorption spectrometry (AAS) are suggested. The results of the investigation of selectivity of the proposed AAS method proved that this procedure is not affected by
Tautkus Stsys +2 more
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Diagnostics, 2023 Several scintigraphic techniques have been supplemented or replaced by PET/CT methods because of their superior sensitivity, high resolution, and absolute activity quantification capability. The purpose of this project was the development of a PET tracer
Robert Drescher +6 more
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Design, Synthesis and Structure-Activity Relationship Studies of Novel Survivin Inhibitors with Potent Anti-Proliferative Properties. [PDF]
PLoS ONE, 2015 The anti-apoptotic protein survivin is highly expressed in most human cancer cells, but has very low expression in normal differentiated cells. Thus survivin is considered as an attractive cancer drug target.
Min Xiao +7 more
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Acta Pharmaceutica Sinica B, 2020 Angiokinases, such as vascular endothelial-, fibroblast- and platelet-derived growth factor receptors (VEGFRs, FGFRs and PDGFRs) play crucial roles in tumor angiogenesis.
Yuqin Yao +10 more
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