Results 21 to 30 of about 74,894 (279)

Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM): a trial for children with sickle cell anemia. [PDF]

Blood, 2017
Hydroxyurea treatment is recommended for children with sickle cell anemia (SCA) living in high-resource malaria-free regions, but its safety and efficacy in malaria-endemic sub-Saharan Africa, where the greatest sickle-cell burden exists, remain unknown.
R. Opoka, C. Ndugwa, Teresa S. Latham, A. Lane, H. Hume, Phillip Kasirye, J. Hodges, R. Ware, C. John   +8 more
semanticscholar   +4 more sources

Hydroxyurea pharmacokinetics and precision dosing in low-resource settings

Frontiers in Molecular Biosciences, 2023
Introduction: Hydroxyurea is effective disease-modifying treatment for sickle cell anemia (SCA). Escalation to maximum tolerated dose (MTD) achieves superior benefits without additional toxicities, but requires dose adjustments with serial monitoring ...
Luke R. Smart, Luke R. Smart, Luke R. Smart, Mwesige Charles, Kathryn E. McElhinney, Min Dong, Min Dong, Alexandra Power-Hays, Alexandra Power-Hays, Alexandra Power-Hays, Thad Howard, Alexander A. Vinks, Alexander A. Vinks, Emmanuela E. Ambrose, Emmanuela E. Ambrose, Russell E. Ware, Russell E. Ware, Russell E. Ware   +17 more
doaj   +1 more source

Hydroxyurea Dose Escalation for Sickle Cell Anemia in Sub-Saharan Africa.

New England Journal of Medicine, 2020
BACKGROUND Hydroxyurea has proven safety, feasibility, and efficacy in children with sickle cell anemia in sub-Saharan Africa, with studies showing a reduced incidence of vaso-occlusive events and reduced mortality.
C. John, R. Opoka, Teresa S. Latham, H. Hume, Catherine Nabaggala, Phillip Kasirye, C. Ndugwa, A. Lane, R. Ware   +8 more
semanticscholar   +1 more source

Patterns of Hydroxyurea Prescription and Use in Routine Clinical Management of Polycythemia Vera: A Multicenter Chart Review Study

Turkish Journal of Hematology, 2020
Objective: This study aimed to evaluate real-life data on patterns of hydroxyurea prescription/use in polycythemia vera (PV). Materials and Methods: This retrospective chart review study included PV patients who had received hydroxyurea therapy for at ...
Yahya Büyükaşık, Rıdvan Ali, Mehmet Turgut, Güray Saydam, Akif Selim Yavuz, Ali Ünal, Muhlis Cem Ar, Orhan Ayyıldız, Fevzi Altuntaş, Müfide Okay, Rafiye Çiftçiler, Özgür Meletli, Nur Soyer, Metban Mastanzade, Zeynep Güven, Teoman Soysal, Abdullah Karakuş, Tuğçe Nur Yiğenoğlu, Barış Uçar, Ece Gökçen, Tülin Tuğlular   +20 more
doaj   +1 more source

Incorporation of thymidine into onion root meristematic cell nuclei in presence of hydroxyurea and its role in recovery of mitotic activity

Acta Societatis Botanicorum Poloniae, 2015
Hydroxyurea treatment of onion roots induced mitotic block which was released by transfer of bulbs to water, and also to some extent by addition of cold or 3H-thymidine to hydroxyurea solutions.
H. Habdas
doaj   +1 more source

Effective use of hydroxyurea for sickle cell anemia in low-resource countries.

Current opinion in hematology, 2020
PURPOSE OF REVIEW Over the past several decades, hydroxyurea has emerged as a well tolerated and potent disease-modifying therapy for children and adults with sickle cell anemia (SCA).
A. Power-Hays, R. Ware
semanticscholar   +1 more source

Integration of Mobile Health Into Sickle Cell Disease Care to Increase Hydroxyurea Utilization: Protocol for an Efficacy and Implementation Study

JMIR Research Protocols, 2020
BackgroundHydroxyurea prevents disease complications among patients with sickle cell disease (SCD). Although its efficacy has been endorsed by the National Health Lung and Blood Institute evidence-based guidelines, its adoption is low, both by patients ...
Hankins, Jane S, Shah, Nirmish, DiMartino, Lisa, Brambilla, Donald, Fernandez, Maria E, Gibson, Robert W, Gordeuk, Victor R, Lottenberg, Richard, Kutlar, Abdullah, Melvin, Cathy, Simon, Jena, Wun, Ted, Treadwell, Marsha, Calhoun, Cecelia, Baumann, Ana, Potter, Michael B, Klesges, Lisa, Bosworth, Hayden   +17 more
doaj   +1 more source

Hydroxyurea for Children with Sickle Cell Anemia in Sub‐Saharan Africa

New England Journal of Medicine, 2019
BACKGROUND Hydroxyurea is an effective treatment for sickle cell anemia, but few studies have been conducted in sub‐Saharan Africa, where the burden is greatest.
L. Tshilolo, G. Tomlinson, T. Williams, Brígida Santos, P. Olupot‐Olupot, A. Lane, B. Aygun, Susan E Stuber, Teresa S. Latham, Patrick T. McGann, R. Ware   +10 more
semanticscholar   +1 more source

DNA polymerase α (swi7) and the flap endonuclease fen1 (rad2) act together in the s-phase alkylation damage response in S. pombe [PDF]

, 2012
Polymerase α is an essential enzyme mainly mediating Okazaki fragment synthesis during lagging strand replication. A specific point mutation in Schizosaccharomyces pombe polymerase α named swi7-1, abolishes imprinting required for mating-type switching ...
Jacob Z. Dalgaard, Martin G. Marinus, Milana Koulintchenko, Prakash Arumugam, Sonya Vengrova, Trevor Eydmann   +5 more
core   +4 more sources

Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling [PDF]

, 2007
Large brain size is one of the defining characteristics of modern humans. Seckel syndrome (MIM 210600), a disorder of markedly reduced brain and body size, is associated with defective ATR-dependent DNA damage signaling.
A Kramer, A Purohit, Anand Saggar, Andrew P Jackson, Ben Hamel, Bertrand Vernay, C Ponting, Carol-Anne Martin, CG Woods, D Chen, D Diviani, Elen Griffith, F Majewski, F Ruschendorf, GK Alderton, GK Alderton, H Dodson, H Loffler, H Niida, HPG Seckel, J Bond, J Bond, JB Dictenberg, K Miyoshi, M Martinez-Campos, M O'Driscoll, Mark O'Driscoll, MR Flory, Nouriya Al Sanna, P Brown, Paola Vagnarelli, Penny A Jeggo, Q Li, RD Martin, S Doxsey, S Sengupta, S Zhang, Sarah Walker, SJ Doxsey, Tom Stiff, WC Zimmerman, William C Earnshaw, Y Shiloh   +42 more
core   +4 more sources