Results 51 to 60 of about 4,292 (208)

Quantitative Assessment of Hyoscyamine and Scopolamine Tropane Alkaloids in Root and Shoot of Hyoscyamus spp. from Iran

Journal of Medicinal Plants, 2015
Background: Different species of Hyoscymaus are rich sources of tropane alkaloids, especially hyoscyamine and scopolamine. These compounds medicinally are important tropane alkaloids that exclusively are produced by plants.
F Fattahi, A Shojaeiyan, H Askari, H Naghdi Badi, Ayyari M, Mokhtassi-Bidgoli A, Palazon Barandela J   +6 more
doaj  

Promoting the accumulation of scopolamine and hyoscyamine in Hyoscyamus niger L. through EMS based mutagenesis.

PLoS ONE, 2020
The overexploitation of medicinal plants is depleting gene pool at an alarming rate. In this scenario inducing the genetic variability through targeted mutations could be beneficial in generating varieties with increased content of active compounds.
Durdana Shah, Azra N Kamili, Aijaz A Wani, Umer Majeed, Zubair Ahmad Wani, Nasreena Sajjad, Parvaiz Ahmad   +6 more
doaj   +1 more source

Catalytic innovation underlies independent recruitment of polyketide synthases in cocaine and hyoscyamine biosynthesis

Nature Communications, 2022
Cocaine is a tropane alkaloid produced by Erythroxylum novogranatense. Here the authors identify two polyketide synthases involved in cocaine biosynthesis and provide insight into the parallel evolution of these enzymes in tropane alkaloids-producing ...
Tian Tian, Yong-Jiang Wang, Jian-Ping Huang, Jie Li, Bingyan Xu, Yin Chen, Li Wang, Jing Yang, Yijun Yan, Sheng-Xiong Huang   +9 more
doaj   +1 more source

Two‐step epoxidation of hyoscyamine to scopolamine is catalyzed by bifunctional hyoscyamine 6β‐hydroxylase [PDF]

FEBS Letters, 1993
In several solanaceous plants, hyoscyamine is first hydroxylated at the 6β‐position, and then epoxidized to scopolamine. We expressed hyoscyamine 6β‐hydroxylase (H6H) in Escherichia coli as a fusion protein with maltose‐binding protein. The crude cell extract from the bacterium that expressed the soluble fusion protein showed a strong hydroxylase ...
Hashimoto, Takashi, Matsuda, Jun, Yamada, Yasuyuki   +2 more
openaire   +2 more sources

The promoter from SlREO, a highly-expressed, root-specific Solanum lycopersicum gene, directs expression to cortex of mature roots [PDF]

, 2008
Root-specific promoters are valuable tools for targeting transgene expression, but many of those already described have limitations to their general applicability.
Abe, Andrew J. Thompson, Bassett, Benfey, Bird, Bradford, Bucher, Bucher, Butler, Cardon, Carole Wright, Chan, Chen, Diatchenko, Elmayan, Fester, Garoosi, Giritch, Giritch, Gittins, Grichko, Gubler, Hagen, Hans, Hausinger, Hertig, Higo, Hudson, Ian B. Taylor, Itzhaki, Jefferson, John Andrews, Karimi, Keller, Kenneth Manning, Klinedinst, Koyama, Krasnyanski, K�ck, Liang, Liedl, L�on-Kloosterziel, Marin, Matsuda, Matthew O. Jones, Mudge, Mudge, Okubara, Phillips, Prescott, Prescott, Radi, Ro, Saslowsky, Sobeih, Subramanian, Suzuki, Tang, Thompson, Tirajoh, Vaughan, von Schweinichen, White, Xiao, Xu, Yamamoto, Yoshimoto, Zhang, Zhang   +68 more
core   +1 more source

High‐Throughput Screening Using the Self‐Controlled Tree‐Based Scan Statistic to Identify Medications Associated With Hospitalization for Severe Acute Liver Injury

Pharmacoepidemiology and Drug Safety, Volume 34, Issue 12, December 2025.
ABSTRACT Background Medications associated with acute liver injury (ALI) are primarily identified by case reports. High‐throughput screening of real‐world data could be leveraged to detect hepatotoxicity signals. Objective To apply tree‐based scan statistics in real‐world data to identify drugs associated with hospitalization for severe ALI among ...
Vincent Lo Re III, Craig W. Newcomb, Dean M. Carbonari, Charles E. Leonard, Christopher T. Rentsch, Judith C. Maro   +5 more
wiley   +1 more source

Synergistic effects of polyploidization and elicitation on biomass and hyoscyamine content in hairy roots of Datura stramonium

Biotechnologie, Agronomie, Société et Environnement, 2016
Description of the subject. The hyoscyamine, a tropane alkaloid, widely used in medicine, can be produced from Datura sp. (Solanaceae). However, its content in the spontaneous roots remains low; therefore, hairy roots (HRs) were envisaged as a potential ...
Belabbassi, O., Khelifi-Slaoui, M., Zaoui, D., Benyammi, R., Khalfallah, N., Malik, S., Makhzoum, A., Khelifi, L.   +7 more
doaj  

Enantiomeric separation of (-) and (+)- hyosciamine by high performance liquid chromatography-tandem mass spectrometry [PDF]

, 2016
Interest in natural toxins produced by fungi or plants has grown in recent years due to its toxicity and its impact on feeding and animal feed and human food safety.
Garrido Frenich, Antonia, López-Ruiz, Rosalía, Martínez Vidal, José Luis, Marín-Sáez, Jesús, Romero González, Roberto   +4 more
core   +1 more source

Concurrent Alcohol Use and the Relative Risk of Community‐Acquired Pneumonia Associated With Anticholinergic and Non‐Anticholinergic Neurocognitively Active Medication Receipt: A National Nested Case–Control Study Among US Veterans

Pharmacoepidemiology and Drug Safety, Volume 34, Issue 12, December 2025.
ABSTRACT Purpose Anticholinergic medications and alcohol each independently increase the risk of community‐acquired pneumonia (CAP). Whether non‐anticholinergic neurocognitively active medications also increase risk, and if alcohol modifies these associations, remains unclear. Methods We conducted a nested case–control study using Veterans Aging Cohort
William H. Wang, Kristina Crothers, Kathleen M. Akgün, Kirsha S. Gordon, Maria C. Rodriguez‐Barradas, Julie A. Womack, Jennifer Thompson, Amy C. Justice, Christopher T. Rentsch   +8 more
wiley   +1 more source

Roots of Indian heliotrope (Heliotropium indicum) produce simple pyrrolizidine alkaloids using the same homospermidine oxidase involved in biosynthesis of complex pyrrolizidine alkaloids in aerial parts

Plant Biology, Volume 27, Issue 7, Page 1378-1390, December 2025.
Indian heliotrope uses the same oxidase to produce complex pyrrolizidine alkaloid esters in aerial parts and simple pyrrolizidine alkaloids in roots. Abstract Pyrrolizidine alkaloids (PAs) are toxic specialized metabolites found in several plant lineages with independent evolutionary origins.
M. M. Zakaria, M.‐B. Salewski, D. Ober
wiley   +1 more source