Results 51 to 60 of about 2,267,031 (171)

Immunoglobulin class‐switch recombination: Mechanism, regulation, and related diseases

MedComm
Maturation of the secondary antibody repertoire requires class‐switch recombination (CSR), which switches IgM to other immunoglobulins (Igs), and somatic hypermutation, which promotes the production of high‐affinity antibodies.
Jia‐Chen Liu, Ke Zhang, Xu Zhang, Fei Guan, Hu Zeng, Masato Kubo, Pamela Lee, Fabio Candotti, Louisa Katherine James, Niels Olsen Saraiva Camara, Kamel Benlagha, Jia‐Hui Lei, Huamei Forsman, Lu Yang, Wei Xiao, Zheng Liu, Chao‐Hong Liu   +16 more
doaj   +1 more source

Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to TNF receptor blockade with etanercept

Hereditary periodic fever syndromes comprise a group of distinct disease entities linked by the defining feature of recurrent febrile episodes. Hyper IgD with periodic fever syndrome (HIDS) is caused by mutations in the mevalonate kinase (MVK) gene.
Mirakian RM, Waterhan HR, Hammond LJ, Vijaydurai PI, Houten SM, Tomlin P, Frenkel J, McDermottt MF, Aganna E, Arkwright PD, Cant AJ   +10 more
core   +5 more sources

AUTOINFLAMMATORY DISEASES IN RHEUMATOLOGY: RUSSIAN EXPERIENCE

Научно-практическая ревматология, 2016
Autoinflammatory diseases (AIDs) are characterized by periodic, sometimes self-limiting attacks that appear as fever and clinical symptoms resembling rheumatic ones, in the absence of autoimmune or infectious diseases.
S. O. Salugina, E. S. Fedorov, N. N. Kuzmina, E. A. Kamenets, E. Yu. Zakharova   +4 more
doaj   +1 more source

Addition of Intravenous Immunoglobulin in Refractory Cutaneous Polyarteritis Nodosa: A Case Report

Case Reports in Rheumatology, Volume 2026, Issue 1, 2026.
Background Cutaneous polyarteritis nodosa (cPAN) is a rare necrotizing vasculitis affecting medium‐sized skin vessels and may be refractory to standard immunosuppressive therapies. Case Presentation We report a 23‐year‐old male with HLA‐B27–positive enthesitis‐associated arthritis (ERA), which was reclassified during the disease course and is currently
Fabio Kohlmann, Daniela Odehnal, Laura Buchtala, Anna Kernder, Xenofon Baraliakos, Ankit Dhoundiyal   +5 more
wiley   +1 more source

Recent Insights into the Pathogenesis of Type AA Amyloidosis

The Scientific World Journal, 2011
The amyloidoses are a group of life-threatening diseases in which fibrils made of misfolded proteins are deposited in organs and tissues. The fibrils are stable, insoluble aggregates of precursor proteins that have adopted an antiparallel β-sheet ...
J. C. H. van der Hilst
doaj   +1 more source

Review of Biological Agents in the Therapeutic Management of Monogenic Genodermatoses

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Monogenic genodermatoses encompass a diverse group of over 400 distinct disorders, presenting significant therapeutic challenges. Recent advancements in the clinical application of biological agents have heralded a new era in the management of these conditions.
Xueying Wang, Qing Zhao, Hong Liu, Furen Zhang, Zhiqiang Song   +4 more
wiley   +1 more source

Current directions in hyper-programming [PDF]

, 2000
The traditional representation of a program is as a linear sequence of text. At some stage in the execution sequence the source text is checked for type correctness and its translated form is linked to values in the environment.
Graham N. C. Kirby, Cutts, Quintin I, Quintin I. Cutts, Farkas, Alex, Kirby, Graham N C, Robert McGettrick, Morrison, R, Alex Farkas, Kirby, G N C, Dearle, A, Connor, R C H, McGettrick, R, Evangelos Zirintsis, Connor, Richard C H, Dearle, Alan, Richard C. H. Connor, Ronald Morrison, Cutts, Q I, Farkas, A, Morrison, Ronald, Zirintsis, Evangelos, Alan Dearle, McGettrick, Robert   +22 more
core   +1 more source

Effective interleukin-6 inhibition in a pediatric patient with mevalonate kinase deficiency and chronic nonbacterial osteomyelitis–like bone lesions under interleukin-1 blockade

The Turkish Journal of Pediatrics
Background. Mevalonate kinase deficiency (MKD) is a rare autosomal recessive autoinflammatory disease. Chronic nonbacterial osteomyelitis (CNO) represents another autoinflammatory disorder characterized by sterile bone inflammation.
Eray Tunce, Sıla Atamyıldız Uçar, Sevinç Taşar, Metin Eser, Betül Sözeri   +4 more
doaj   +1 more source

Cytokine Signatures Outperform Immune Subsets in Machine Learning Models for Predicting Acute Graft‐Versus‐Host Disease at Neutrophil Engraftment

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Background Acute graft‐versus‐host disease (aGvHD) is a major immune complication of allogeneic hematopoietic stem cell transplantation (Allo‐HSCT), driven by complex immune‐cytokine interactions. This study employed machine learning (ML) algorithms to develop early predictive models for aGvHD using immune and cytokine profiles of Allo‐HSCT recipients ...
Mohini Mendiratta, Praful Pandey, Shobhit Pandey, Sandeep Rai, Meenakshi Mendiratta, Hridayesh Prakash, Shuvadeep Ganguly, Archana Sasi, Ritu Gupta, Prabhat Singh Malik, Raja Pramanik, Sachin Kumar, Baibaswata Nayak, Riyaz Ahmed Mir, Sameer Bakhshi, Deepam Pushpam, Mukul Aggarwal, Aditya Kumar Gupta, Rishi Dhawan, Tulika Seth, Manoranjan Mahapatra, Ranjit Kumar Sahoo, Poorani Gurumallesh Prabu   +22 more
wiley   +1 more source

Hyperimmunoglobulinemia D Syndrome Masquerading as Familial Mediterranean Fever, Hidradenitis Suppurativa, and Crohn’s Disease: A Case Report

Saudi Journal of Medicine and Medical Sciences
We report a rare case of hyperimmunoglobulinemia D syndrome (HIDS) in a young man who was initially diagnosed with familial Mediterranean fever, hidradenitis suppurativa, and, eventually, with Crohn’s disease.
Mohamed Juraij, Farah Barakat, Zainab Ifthikar, Fahad Alsohaibani   +3 more
doaj   +1 more source