Results 61 to 70 of about 2,267,031 (171)

Multi‐omic analysis identifies biological processes underlying progressive interstitial lung disease in systemic sclerosis

The FEBS Journal, Volume 292, Issue 22, Page 6054-6074, November 2025.
Systemic sclerosis (SSc) is a rare autoimmune disease, and lung complications (ILD) are the main cause of death. This study compared SSc patients with and without lung disease to healthy volunteers. We found increased inflammation, specific proteins, and higher triglyceride levels linked to lung disease progression. These findings suggest triglycerides
Selena Bouffette, Perrine Soret, Alice Cole, Emmanuel Nony, Pierre Barbier Saint Hilaire, Grégory Leclerc, Lamine Alaoui, Audrey Aussy, Isabelle Wehrle, Aude Le Gall, Mark Coulon, Marc Pallardy, Voon Ong, Jeanne Allinne, Philippe Moingeon, David Abraham, Christopher P. Denton   +16 more
wiley   +1 more source

Human γδ T Cell Function Is Impaired Upon Mevalonate Pathway Inhibition

Immunology, Volume 175, Issue 3, Page 300-322, July 2025.
Mevalonate pathway is important for the effector function of gammadelta T cells. Inhibition of the pathway in vivo and in vitro impairs cytokine and cytotoxic molecule production by mainly affecting protein prenylation and disturbing intracellular signalling in Vdelta2 T cells. Created with Biorender.
Tsz Kin Suen, Burcu Al, Thomas Ulas, Nico Reusch, Harsh Bahrar, Siroon Bekkering, Jaydeep Bhat, Dieter Kabelitz, Joachim L. Schultze, Frank L. van de Veerdonk, Jeanine Roeters van Lennep, Niels P. Riksen, Leo A. B. Joosten, Mihai G. Netea, Katarzyna Placek   +14 more
wiley   +1 more source

Mevalonate kinase-deficient THP-1 cells show a disease-characteristic pro-inflammatory phenotype

Frontiers in Immunology
ObjectiveBi-allelic pathogenic variants in the MVK gene, which encodes mevalonate kinase (MK), an essential enzyme in isoprenoid biosynthesis, cause the autoinflammatory metabolic disorder mevalonate kinase deficiency (MKD).
Frouwkje A. Politiek, Frouwkje A. Politiek, Marjolein Turkenburg, Rob Ofman, Hans R. Waterham, Hans R. Waterham, Hans R. Waterham   +6 more
doaj   +1 more source

The Immunology of Alpha‐Gal Syndrome: History, Tick Bites, IgE, and Delayed Anaphylaxis to Mammalian Meat

Immunological Reviews, Volume 332, Issue 1, July 2025.
ABSTRACT The primary features of the alpha‐gal syndrome (AGS) are (i) The IgE ab that are causally related to anaphylaxis with infusions of Cetuximab are specific for galactose alpha‐1,3‐galactose. (ii) In the USA, this IgE ab is induced by bites of the tick Amblyomma americanum. (iii) The anaphylactic reactions to food derived from non‐primate mammals
Thomas A. E. Platts‐Mills, Roopesh Singh Gangwar, Lisa Workman, Jeffrey M. Wilson   +3 more
wiley   +1 more source

Long-term follow up of Hyper IgD syndrome: a national collaborative study

, 2011
The paper deals with long-term follow up of children with hyper IgD syndrome in a large national collaborative ...
Rigante, D
core  

Skin involvement in rare monogenic autoinflammatory diseases. Part 2

Современная ревматология
Autoinflammatory diseases (AIDs) represent a heterogeneous group of conditions pathogenetically associated with dysregulation of the innate immune system and clinically characterized by recurrent episodes of sterile inflammation in the affected organs in
S. O. Salugina, E. S. Fedorov, A. V. Torgashina, M. I. Kaleda, M. F. Beketova, A. Yu. Sukhanina   +5 more
doaj   +1 more source

Pediatric anaphylaxis and hyper IgE syndrome

, 2017
Amrita Dosanjh Department of Pediatrics, Rady Childrens Hospital, San Diego, CA, USA Abstract: Patients with autosomal-dominant (AD) hyper immunoglobulin E (IgE) syndrome (HIES) or Job syndrome develop frequent dermatologic and pulmonary infections.
Dosanjh A
core  

Hyper-IgE syndrome, 2021 update

, 2021
Clinically and pathologically, the patients with hyper-IgE syndrome present similar skin manifestations to common atopic dermatitis. The original hyper-IgE syndrome is characterized by diminished inflammatory response, in combination with Staphylococcus ...
Yoshiyuki Minegishi
core   +1 more source

Persistent hyper-programs [PDF]

, 2011
This work was supported by ESPRIT III Basic Research Action 6309 – FIDE 2 and SERC grant GR/F 02953.The traditional representation of a program as a linear sequence of text forces a particular style of program construction to ensure good programming ...
Dearle, Alan, Farkas, AM, Connor, RCH, Morrison, Ronald, Kirby, Graham Njal Cameron, Cutts, QI   +5 more
core   +2 more sources

Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to TNF receptor blockade with etanercept

, 2002
Hereditary periodic fever syndromes comprise a group of distinct disease entities linked by the defining feature of recurrent febrile episodes. Hyper IgD with periodic fever syndrome (HIDS) is caused by mutations in the mevalonate kinase (MVK) gene.
Houten, S. M., Waterham, H. R., Mirakian, R. M., Vijaydurai, P. I., Hammond, L. J., McDermott, M. F., Arkwright, P. D., Tomlin, P. I., Cant, A. J., Frenkel, J., Aganna, E.   +10 more
core   +1 more source