Results 11 to 20 of about 5,132 (186)

Immunoglobulin class‐switch recombination: Mechanism, regulation, and related diseases [PDF]

MedComm
Maturation of the secondary antibody repertoire requires class‐switch recombination (CSR), which switches IgM to other immunoglobulins (Igs), and somatic hypermutation, which promotes the production of high‐affinity antibodies.
Jia‐Chen Liu, Ke Zhang, Xu Zhang, Fei Guan, Hu Zeng, Masato Kubo, Pamela Lee, Fabio Candotti, Louisa Katherine James, Niels Olsen Saraiva Camara, Kamel Benlagha, Jia‐Hui Lei, Huamei Forsman, Lu Yang, Wei Xiao, Zheng Liu, Chao‐Hong Liu   +16 more
doaj   +3 more sources

Hyperimmunoglobulinemia D Syndrome Masquerading as Familial Mediterranean Fever, Hidradenitis Suppurativa, and Crohn’s Disease: A Case Report [PDF]

Saudi Journal of Medicine and Medical Sciences
We report a rare case of hyperimmunoglobulinemia D syndrome (HIDS) in a young man who was initially diagnosed with familial Mediterranean fever, hidradenitis suppurativa, and, eventually, with Crohn’s disease.
Mohamed Juraij, Farah Barakat, Zainab Ifthikar, Fahad Alsohaibani   +3 more
doaj   +2 more sources

Hyper-IgD syndrome: a new mutation (p.R277G) with a severe phenotype [PDF]

Pediatric Rheumatology Online Journal, 2011
Conde M, Neves C, Brito MJ, Arostégui JI, Santos J   +4 more
doaj   +2 more sources

Hyper IGD syndrome: A case report

Pediatric Hematology Oncology Journal, 2016
Mohammed Naseer, P. Taur, A. Parmar, P. Kanvinde, S. Mudaliar, N. Dighe, P. Keni, A. Pandrowala, M. Madkaikar, A. Dalvi, A. Mishra, B. Agarwal, Y. Amdekar, M. Desai   +13 more
doaj   +2 more sources

Persistent Hyper IgA as a Marker of Immune Deficiency: A Case Report

Antibodies, 2022
An elevated IgA level obtained in a 10-year-old male a year after an episode of pneumococcal sepsis led to the discovery of a broad-based IgG-specific antibody deficiency syndrome.
Russell J. Hopp, Hana B. Niebur
doaj   +1 more source

Post-Acute Sequelae Patients with Severe COVID-19 History Show a Prolonged Inflammatory, Vascular Injury Pattern. [PDF]

Eur J Immunol
Long‐COVID or post‐acute sequelae of COVID‐19 syndrome (PASC) patients with previous severe COVID‐19 ICU history prior vaccination display sustained significant changes in their immune profile at both the cellular and the inflammatory level, revealing signatures of persistent inflammation and endothelial injury.
Ruhl L, Pink I, Chichelnitskiy E, Drick N, Sauer A, Boblitz L, Beushausen K, Keil J, Ullrich AL, Schmidt J, Hoeper MM, Welte T, Kühne JF, Falk CS.   +13 more
europepmc   +2 more sources

Das Hyper-IgD-Syndrom [PDF]

DMW - Deutsche Medizinische Wochenschrift, 2008
Contains fulltext : 23622___.PDF (Publisher’s version ) (Open Access)
Drenth, J.P.H., Endres, S., Belohradsky, B.H., Meer, J.W.M. van der   +3 more
openaire   +2 more sources

Mevalonate kinase deficiency syndrome: Single center experience

Научно-практическая ревматология, 2021
The aim of this study was to analyze the clinical, laboratory and molecular genetic data of 26 patients (15 boys, 11 girls) diagnosed with mevalonate kinase deficiency syndrome (MKD).Subjects and methods.
A. L. Kozlova, V. O. Bludova, V. I. Burlakov, E. V. Raykina, T. V. Varlamova, М. А. Kurnikova, А. N. Remizov, G. V. Tereshchenko, А. А. Moiseeva, S. А. Dibirova, А. L. Khoreva, А. А. Roppelt, Yu. А. Rodina, N. B. Kuzmenko, А. А. Mukhina, Е. I. Каlashnikova, L. N. Igisheva, N. V. Martynova, О. V. Zhogova, S. B. Zimin, О. V. Barabanova, Yu. V. Kotova, G. А. Novichkova, А. Yu. Shcherbina   +23 more
doaj   +1 more source

Compromised Protein Prenylation as Pathogenic Mechanism in Mevalonate Kinase Deficiency

Frontiers in Immunology, 2021
Mevalonate kinase deficiency (MKD) is an autoinflammatory metabolic disorder characterized by life-long recurring episodes of fever and inflammation, often without clear cause. MKD is caused by bi-allelic pathogenic variants in the MVK gene, resulting in
Frouwkje A. Politiek, Hans R. Waterham
doaj   +1 more source

Human γδ T Cell Function Is Impaired Upon Mevalonate Pathway Inhibition. [PDF]

Immunology
Mevalonate pathway is important for the effector function of gammadelta T cells. Inhibition of the pathway in vivo and in vitro impairs cytokine and cytotoxic molecule production by mainly affecting protein prenylation and disturbing intracellular signalling in Vdelta2 T cells. Created with Biorender.
Suen TK, Al B, Ulas T, Reusch N, Bahrar H, Bekkering S, Bhat J, Kabelitz D, Schultze JL, van de Veerdonk FL, van Lennep JR, Riksen NP, Joosten LAB, Netea MG, Placek K.   +14 more
europepmc   +2 more sources