Results 71 to 80 of about 44,475 (226)

Quantitative Sensory Testing Identifies Altered Thermal and Pain Processing in Trigeminal Neuralgia. [PDF]

Eur J Neurol
DFNS‐based quantitative sensory testing (QST) and sensory phenotyping were performed on the most affected trigeminal division in 65 patients with trigeminal neuralgia (TN). In the overall cohort, QST revealed bilateral thermal hypoesthesia and bilateral pain hyperalgesia, with mechanical and thermal hyperalgesia being the most frequent sensory ...
De Stefano G, Litewczuk D, Galosi E, Di Pietro G, Falco P, Leone C, Osman-Farah J, Bhargava D, O'Neill F, Frank B, Joncas CT, Sekula RF, Di Stefano G, Truini A.   +13 more
europepmc   +2 more sources

Plasma Lidocaine Concentrations During Intravenous Lidocaine Infusion Therapy in the Pediatric Population—A Scoping Review

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Intravenous lidocaine therapy (IVLT) is often used in perioperative multimodal analgesia due to its analgesic, anti‐hyperalgesic, and anti‐inflammatory effects. In adults, IVLT doses of 1–2 mg/kg/h produce plasma concentrations of 1–2 μg/mL, within the presumed therapeutic range of 1–5 μg/mL.
McKenna Postles, Amanda Barton, Nicholas West, Gillian Lauder   +3 more
wiley   +1 more source

Psychophysics/hyperalgesia

The Journal of Pain, 2004
Journal of Pain 5 (2004) S31-S31.
University of Florida, Gainesville, FL USA ( host institution ), Kaplan, L., Fillingim, R., Agbandje-McKenna, M., Staud, R., Glover, T., Campbell, C., Mogil, J., Wallace, M.   +8 more
openaire   +4 more sources

Maresin 2, a Specialized Pro-Resolution Lipid Mediator, Reduces Pain and Inflammation Induced by Bothrops jararaca Venom in Mice

Toxins
The venom of Bothrops jararaca (BjV) induces intense and prolonged pain, which is not alleviated by antivenom, along with hemorrhage and inflammation.
Kassyo L. S. Dantas, Beatriz H. S. Bianchini, Matheus D. V. da Silva, Maiara Piva, Joice M. da Cunha, Janaina M. Zanoveli, Fernanda C. Cardoso, Fabiana T. M. C. Vicentini, Camila R. Ferraz, Patricia B. Clissa, Rubia Casagrande, Waldiceu A. Verri   +11 more
doaj   +1 more source

Local and Non‐Local Sensitization Following Repetitive von Frey Filament Testing in Unoperated Sprague‐Dawley and Lewis Rats

Sensory Neuroscience, EarlyView.
ABSTRACT Plantar and dorsal von Frey (VF) filament assays are widely used to assess mechanical nociception in rodents following peripheral nerve injury, spinal cord injury, and analgesic interventions. However, the effects of repeated testing on withdrawal thresholds and potential sensitization have not been well defined.
Henry Garcia, Guhan Periyasamy, Varun Gokhale, Liwen Zhou, Alexander M. Schafer, Neha Nagarajan, Alexa N. Olivarez, Sushant Sanklipur, Yiming Hao, George D. Bittner   +9 more
wiley   +1 more source

In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations

Acta Pharmaceutica, 2018
The aim of this study is to evaluate the antihyperalgesic and antinociceptive effects of two formulations containing peat water extracts using a model of carrageenan-induced hyperalgesia, combined with a test with a mechanical stimulus, and a hot plate ...
Zagorchev Plamen Ivanov, Apostolova Elisaveta Georgieva, Pilicheva Bissera Asenova, Draganova-Filipova Milena Nenkova, Kokova Vesela Yulieva, Lukanov Julian Borisov   +5 more
doaj   +1 more source

Sensory profile of cats with potential pain‐related diabetic neuropathy

Veterinary Record, EarlyView.
Abstract Background Diabetes mellitus (DM) can cause peripheral neuropathy. This study aimed to evaluate sensory function by measuring the mechanical nociceptive thresholds (MNT) and diffuse noxious inhibitory control (DNIC) of cats with diabetes mellitus (DMcats).
Hélène L. M. Ruel, Vanessa Bruneau, Berenice Conversy, Sabrine Marangoni, Paulo V. Steagall   +4 more
wiley   +1 more source

Role of Transient Receptor Potential Vanilloid Channels in Gastrointestinal Physiology and Pathology

Receptors
Transient Receptor Potential Vanilloid (TRPV) channels represent one of the seven subfamilies of TRP receptors and are widely expressed throughout the human body where they play pivotal roles in various physiological processes.
Omar Tluli, Ahmed Arabi, Humam Emad Rajha, Lana Abugharbieh, Faissal Al Zeir, Maryam Hamdan, Ayeda Abuqaba, Ammar Boudaka   +7 more
doaj   +1 more source

Psilocybin as a novel treatment for chronic pain

British Journal of Pharmacology, EarlyView.
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey, Reena Lasrado, Maria Maiarú, Gary J. Stephens   +3 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source