Results 71 to 80 of about 44,701 (229)

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

RNA Sequencing Dataset of Drosophila Nociceptor Translatomic Response to Injury

Data
To prepare to address the mechanisms of injury-induced nociceptor sensitization, we sequenced the translatome of the nociceptors of injured Drosophila larvae and those of uninjured larvae.
Christine M. Hale, Kyle J. Beauchemin, Courtney L. Brann, Julie K. Moulton, Ramaz Geguchadze, Benjamin J. Harrison, Geoffrey K. Ganter   +6 more
doaj   +1 more source

TRPA1 Channel is Involved in SLIGRL-Evoked Thermal and Mechanical Hyperalgesia in Mice

Medical Sciences, 2019
Persistent itch (pruritus) accompanying dermatologic and systemic diseases can significantly impair the quality of life. It is well known that itch is broadly categorized as histaminergic (sensitive to antihistamine medications) or non-histaminergic ...
Merab G. Tsagareli, Ivliane Nozadze, Nana Tsiklauri, Gulnaz Gurtskaia   +3 more
doaj   +1 more source

Targeting peroxynitrite production in a model of persistent temporomandibular disorder comorbid with migraine

British Journal of Pharmacology, EarlyView.
Background and Purpose The persistence of temporomandibular disorders (TMDs), particularly myogenous, in a person with migraine can lead to exacerbated clinical outcomes and limited response to treatment. The pro‐nociceptive reactive nitroxidative species, peroxynitrite, is involved in migraine mechanisms, but little is known of its role in this ...
Simon Akerman, Ana Belen Salinas‐Abarca, Wei Guo, Daniela Salvemini, Marcela Romero‐Reyes   +4 more
wiley   +1 more source

Neuropathic pain in cerebral palsy and related genetic conditions: A scoping review of prevalence, characteristics, and management

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To map existing evidence on neuropathic pain in cerebral palsy (CP) and related genetic conditions, including prevalence, descriptors, assessment methods, and management. Method Following prospective registration, five databases (Ovid MEDLINE, Embase, CINAHL, Web of Science, Google Scholar) were searched in June 2025.
Aayushi Khillan, Sanya Verma, Hannah Yeomans, Karen Bau, Caitlin Doyle, Monica S. Cooper, David J. Amor, Carolyn Berryman, Adrienne Harvey   +8 more
wiley   +1 more source

Biological characterization of a myotoxin phosphoplipase A2 homologue purified from the venom of the snake Bothrops moojeni

Journal of Venomous Animals and Toxins including Tropical Diseases, 2011
A myotoxin phospholipase A2 homologue, BmooMtx, was isolated from the venom of Bothrops moojeni by a combination of ion-exchange chromatography on DEAE-Sephacel column and gel filtration on Sephadex G-75. SDS-PAGE showed the enzyme to be a monomer with a
MR Queiroz, CC Mamede, KC Fonseca, LCMN Canabrava, LV França, MC Silva, L Stanziola, ME Beletti, HAN Canabrava, F Oliveira   +9 more
doaj   +1 more source

1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty

The FEBS Journal, EarlyView.
Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah, Grace Filbertine, Lucy Gill, Asangaedem Akpan, Marie M. Phelan, Helen Louise Wright   +5 more
wiley   +1 more source

Factors Associated With Endodontic Flare‐Ups: A Systematic Review and Meta‐Analysis

International Endodontic Journal, EarlyView.
ABSTRACT Background Endodontic flare‐ups, characterized by severe postoperative pain and/or swelling requiring unscheduled intervention, remain a clinically significant concern in root canal therapy. Identifying the factors associated with flare‐ups is important for anticipating and managing patient outcomes.
Jun Ohshima, Masayoshi Morita, Yuzo Kawanishi, Shotaro Abe, Nobutake Tanaka, Tsuyoshi Shimaoka, Hazuki Maezono, Yoshifumi Kinomoto, Mikako Hayashi   +8 more
wiley   +1 more source

Analgesic effect of chronic oral administration of aerial part of Marrubium Vulgare in diabetic rats

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2006
BACKGROUND AND OBJECTIVE: Considering the antidiabetic and anti-inflammatory effect of marrubium vulgare (MV), this study was designed to investigate the analgesic effect of MV on formalin-induced nociceptive response (standard formalin test) in diabetic
M Roghani,, T Balouch Nejad Mojarad
doaj  

Sympathetic-Sensory Coupling as a Potential Mechanism for Acupoints Sensitization

Journal of Pain Research, 2023
Xiang Cui,1 Ziyi Zhang,1,2 Hanqing Xi,1 Kun Liu,1 Bing Zhu,1 Xinyan Gao1 1Department of Physiology, Institute of Acupuncture and Moxibustion, Academy of Chinese Medical Sciences, Beijing, 100700, People’s Republic of China; 2College of Acupuncture and ...
Cui X, Zhang Z, Xi H, Liu K, Zhu B, Gao X   +5 more
doaj