Results 61 to 70 of about 16,227 (258)

Preoperative Risk Factors for Opioid Use Predict Self‐Reported Health and Function Up to 6 Months After Anterior Cruciate Ligament Reconstruction

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To identify risk factors that predict the need for rescue opioid use and patient‐reported outcomes following an opioid‐limiting postoperative analgesia protocol after anterior cruciate ligament reconstruction. Methods This prospective cohort study recruited 44 patients undergoing primary arthroscopic‐assisted anterior cruciate ligament ...
Eric V. Neufeld, William DeGouveia, Camille Pinpin, Matthew Zinner, Michael J. Sayegh, Michael J. Meade, Steven E. Rokito   +6 more
wiley   +1 more source

Antihyperalgesic Properties of Honokiol in Inflammatory Pain Models by Targeting of NF-κB and Nrf2 Signaling

Frontiers in Pharmacology, 2018
The present study investigates the possible anti-nociceptive effect of intraperitoneal (i.p.) honokiol: a phenolic compound originally isolated from Magnolia officinalis, in acute and chronic inflammatory pain models.
Sidra Khalid, Muhammad Z. Ullah, Ashraf U. Khan, Ruqayya Afridi, Hina Rasheed, Adnan Khan, Hussain Ali, Yeong S. Kim, Salman Khan   +8 more
doaj   +1 more source

CD14 Plays a Critical Role in Pain and Inflammation Across Multiple Models of Post‐traumatic Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine osteoarthritis (OA) models that vary in severity of pathology and rate of progression to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt, Sanique M. South, Natalie S. Adamczyk, Vu Nguyen, Shingo Ishihara, Cheng Zhou, Kate L. Sharp, Sung Y. Kim, Anna E. Rapp, Baofeng Hu, Lance A. Murphy, Li‐Yin Hung, De'Broski Herbert, Joshua F. Baker, Robert L. Mauck, Timothy M. Griffin, Anne‐Marie Malfait, Rachel E. Miller, Carla R. Scanzello   +18 more
wiley   +1 more source

The Edible Brown Seaweed Ecklonia cava Reduces Hypersensitivity in Postoperative and Neuropathic Pain Models in Rats

Molecules, 2014
The current study was designed to investigate whether edible brown seaweed Ecklonia cava extracts exhibits analgesic effects in plantar incision and spared nerve injury (SNI) rats. To evaluate pain-related behavior, we performed the mechanical withdrawal
Jae Goo Kim, Dong Wook Lim, Suengmok Cho, Daeseok Han, Yun Tai Kim   +4 more
doaj   +1 more source

Increased Nociceptive Responses in Streptozotocin-Induced Diabetic Rats and the Related Expression of Spinal NR2B Subunit of -Methyl-D-Aspartate Receptors [PDF]

Diabetes & Metabolism Journal, 2019
BackgroundThis study investigated the role of NR2B in a modulated pain process in the painful diabetic neuropathy (PDN) rat using various pain stimuli.MethodsThirty-two Sprague-Dawley male rats were randomly allocated into four groups (n=8): control ...
Che Aishah Nazariah Ismail, Rapeah Suppian, Che Badariah Abd Aziz, Khalilah Haris, Idris Long   +4 more
doaj   +1 more source

Envolvimento do receptor de potencial transitório A1 (TRPA1) na manutenção da hiperalgesia mecânica e térmica (Frio) na inflamação persistente [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pos-Graduação em Farmacologia, Florianópolis, 2010O presente estudo investiga o papel do receptor TRPA1 no esenvolvimento e manutenção da ...
Costa, Diogo Santos Martins da
core  

Zhiqiao Gancao Decoction Ameliorates Hyperalgesia in Lumbar Disc Herniation via the CCL2/CCR2 Signaling Pathway

, 2023
Zeling Huang,* Binjie Lu,* Xianda Zhang,* Jiangping Wang, Xuefeng Cai, Yujiang Liu, Jianxiong Mo, Yuwei Li, Bo Xu, Xiaofeng Shen Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu, 215008, People’s ...
Liu Y, Li Y, Huang Z, Xu B, Zhang X, Mo J, Wang J, Shen X, Cai X, Lu B   +9 more
core  

Nocebo Hyperalgesia, Partial Reinforcement, and Extinction [PDF]

, 2015
Many studies have found evidence of conditioning-induced nocebo hyperalgesia. However, these studies have exclusively involved continuous reinforcement schedules.
Ben Colagiuri, Colagiuri, Ben, Quinn, Veronica F, Veronica F. Quinn, Colloca, Luana, Luana Colloca   +5 more
core   +1 more source

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

Comparison of effects of intraoperative nefopam and ketamine infusion on managing postoperative pain after laparoscopic cholecystectomy administered remifentanil [PDF]

Korean Journal of Anesthesiology, 2016
BackgroundAlthough intraoperative opioids provide more comfortable anesthesia and reduce the use of postoperative analgesics, it may cause opioid induced hyperalgesia (OIH).
Sung Kwan Choi, Myung Ha Yoon, Jung Il Choi, Woong Mo Kim, Bong Ha Heo, Keun Seok Park, Ji A Song   +6 more
doaj   +1 more source