Results 61 to 70 of about 44,475 (226)

CD14 Plays a Critical Role in Pain and Inflammation Across Multiple Models of Post‐traumatic Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine osteoarthritis (OA) models that vary in severity of pathology and rate of progression to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt, Sanique M. South, Natalie S. Adamczyk, Vu Nguyen, Shingo Ishihara, Cheng Zhou, Kate L. Sharp, Sung Y. Kim, Anna E. Rapp, Baofeng Hu, Lance A. Murphy, Li‐Yin Hung, De'Broski Herbert, Joshua F. Baker, Robert L. Mauck, Timothy M. Griffin, Anne‐Marie Malfait, Rachel E. Miller, Carla R. Scanzello   +18 more
wiley   +1 more source

Correlation between Different Psychological Variables in Women with Fibromyalgia with Symptoms of Neurogenic Inflammation: A Cross-Sectional Study

Biomedicines
Fibromyalgia (FM) is a chronic pain syndrome hypothesized to arise from a state of neurogenic inflammation. Mechanisms responsible for pain, as well as psychological variables, are typically altered in this condition.
Víctor Riquelme-Aguado, Alazne Zabarte-del Campo, Guillermo Baviano-Klett, Josué Fernández-Carnero, Antonio Gil-Crujera, Francisco Gómez-Esquer   +5 more
doaj   +1 more source

Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development

Molecules, 2020
Pathological pain can be initiated after inflammation and/or peripheral nerve injury. It is a consequence of the pathological functioning of the nervous system rather than only a symptom. In fact, pain is a significant social, health, and economic burden
Camila R. Ferraz, Thacyana T. Carvalho, Marília F. Manchope, Nayara A. Artero, Fernanda S. Rasquel-Oliveira, Victor Fattori, Rubia Casagrande, Waldiceu A. Verri   +7 more
doaj   +1 more source

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

Dejerine-Roussy Syndrome: Understanding Chronic Thalamic Pain [PDF]

Journal of Clinical and Diagnostic Research
A 50-year-old male, known to be hypertensive and non compliant with medications, with a significant past history of stroke three months ago, presented to the hospital with chief complaints of persistent burning sensations in his left arm and leg, as well
Saket S Toshniwal, Jiwan Kinkar, Yatika Chadha, Sourya Acharya, Sunil Kumar   +4 more
doaj   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Heat pain detection threshold is associated with the area of secondary hyperalgesia following brief thermal sensitization: a study of healthy male volunteers

Journal of Pain Research, 2017
Morten Sejer Hansen,1 Jørn Wetterslev,2 Christian Bressen Pipper,3 Mohammad Sohail Asghar,1 Jørgen Berg Dahl4 1Department of Anesthesiology, 4231, Centre of Head and Orthopedics, Rigshospitalet, 2Copenhagen Trial Unit, Centre for Clinical ...
Hansen MS, Wetterslev J, Pipper CB, Asghar MS, Dahl JB   +4 more
doaj  

Ultrasound‐Guided Liposomal vs. Conventional Bupivacaine Erector Spinae Plane Block Plus Gabapentin for Postherpetic Neuralgia

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to compare efficacy and safety of ultrasound‐guided erector spinae plane block (ESPB) using liposomal (LB) versus conventional bupivacaine (CB), each plus standardized gabapentin, in patients with postherpetic neuralgia (PHN). A total of 116 PHN patients were randomized to ESPB‐LB or ESPB‐CB; both groups received standardized ...
Xia‐Jing Xu, Li‐Juan Liu, Fa‐Ming Xu, Xiang‐Yu Fang   +3 more
wiley   +1 more source

The Involvement of Endothelin Pathway in Chronic Psychological Stress-Induced Bladder Hyperalgesia Through Capsaicin-Sensitive C-Fiber Afferents

Journal of Inflammation Research, 2022
Chuying Qin,1 Yinhuai Wang,1 Sai Li,2 Yuanyuan Tang,3 Yunliang Gao1 1Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, 410011, People’s Republic of China; 2Acupuncture and Tuina School, Hunan University of Chinese ...
Qin C, Wang Y, Li S, Tang Y, Gao Y
doaj  

Low‐Frequency Stimulation Provides Significant Added Benefit for Postpartum Urinary Incontinence: A Retrospective Cohort Study

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims To evaluate the clinical efficacy of low‐frequency electrical stimulation (LES) in treating UI among postpartum women. Methods Postpartum women diagnosed with UI who received treatment at two tertiary hospitals between 1st January and 30th June 2020 were included.
Yaxin Liang, Li Gu, Tianzi Gai, Yue Yu, Xinyue Zhang, Min Li   +5 more
wiley   +1 more source