Results 81 to 90 of about 44,701 (229)

The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, EarlyView.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source

The effect of AqueousExtractofElaeagnusangustifolia on Diabetic Neuropathic Pain in Streptozotocin-induced Diabetic Rats

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2015
Background and Objectives:One of the common complications of diabetes is nervous system disorder and diabetic neuropathy. In various studies, it has been reported that flavonoid and polyphenolic compounds of plants improve diabetic neuropathy. Due to the
Omid Reza Tamtaji, SayedAlireza Talaei, Mohsen Taghizadeh   +2 more
doaj  

Disease-modifying rdHSV-CA8* non-opioid analgesic gene therapy treats chronic osteoarthritis pain by activating Kv7 voltage-gated potassium channels

Frontiers in Molecular Neuroscience
Chronic pain is common in our population, and most of these patients are inadequately treated, making the development of safer analgesics a high priority.
Gerald Z. Zhuang, William F. Goins, Munal B. Kandel, Marco Marzulli, Mingdi Zhang, Joseph C. Glorioso, Yuan Kang, Alexandra E. Levitt, Konstantinos D. Sarantopoulos, Konstantinos D. Sarantopoulos, Roy C. Levitt, Roy C. Levitt, Roy C. Levitt, Roy C. Levitt   +13 more
doaj   +1 more source

Nurses' Experiences of Pain Management for Patients With Diagnosed Mental Health Conditions: A Systematic Review

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To synthesise the available evidence related to nurses' pain assessment and management practices for patients with diagnosed mental health conditions. Design Mixed‐methods systematic review. Data Sources Medline, CINAHL, PsycINFO, SPORTDiscus and Psychology and Behavioural Sciences Collection.
Aaron Lapuz Alejandro, Yvonne Middlewick, Seng Giap Marcus Ang, Rosemary Saunders, Irene Ngune   +4 more
wiley   +1 more source

Camphor Attenuates Hyperalgesia in Neuropathic Pain Models in Mice

Journal of Pain Research, 2023
Ziyuan Li,1,* Yu Gan,1,* Ting Kang,1,* Yi Zhao,1 Tianguang Huang,2 Yuhao Chen,3 Jin Liu,1 Bowen Ke1 1Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of ...
Li Z, Gan Y, Kang T, Zhao Y, Huang T, Chen Y, Liu J, Ke B   +7 more
doaj  

Bridging gaps in diabetic neuropathy care: A Delphi‐based regional consensus from the Gulf Cooperation Council

Journal of Diabetes Investigation, EarlyView.
A three‐round Delphi consensus developed GCC‐specific, evidence‐based recommendations for diabetic peripheral neuropathy (DPN) and painful diabetic neuropathy (PND). The consensus emphasizes proactive screening, early multimodal management, and addressing regional barriers to improve early detection, optimize management, and enhance quality of life ...
Abdulrahman Alshaikh, Abdulnabi T Alattar, Ahmed Abdul Karim Hassoun, Afaf Alshammary, Hussein Elbadawi, Khaled Aldossari, Noor Al Busaidi, Saud Alsifri, Talal Muzaffar, Wiam I. Hussein, Christine Talaat, Abanoub Effat, Marwa Elsaghier, Rayaz A Malik   +13 more
wiley   +1 more source

Effects of Aerobic Exercise and Strength Training on Nociplastic Pain and Clinical Features in Temporomandibular Disorders With Myalgia: A Randomized‐Controlled Trial

Journal of Oral Rehabilitation, EarlyView.
In this randomized controlled trial, adding aerobic exercise or strength training to physical therapy improved outcomes in patients with temporomandibular disorders and nociplastic pain. Aerobic exercise produced greater reductions in pain and central sensitization‐related symptoms, whereas strength training improved trapezius muscle strength and long ...
Flora Dantony, Daniel Romero‐Rodríguez, David Blanco, Carlos Antonio Zárate‐Tejero, Carolina Climent‐Sanz, Cristina Pérez‐Mánen, Andrea Màcia‐Martí, Natalia Felipe‐Spada, Andoni Carrasco‐Uribarren   +8 more
wiley   +1 more source

Psychophysical changes after total sleep deprivation and experimental muscle pain

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Sleep disturbances exacerbate chronic pain, increase psychological load, and increase inflammation. Delayed onset muscle soreness (DOMS) mimics aspects of chronic pain, predominantly affecting peripheral pain mechanisms, while experimental sleep provocations have been shown to impact central pain mechanisms.
Emma Hertel, Elaxmi Sathiyalingam, Linea Pilgaard, Simone Juline Brommann, Rocco Giordano, Kristian Kjær‐Staal Petersen   +5 more
wiley   +1 more source

Characterization of the Pharmacokinetics and Physiological Effects of Tapentadol in Horses

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Tapentadol is a dual mechanism analgesic utilizing both μ‐opioid receptor (MOR) agonism and norepinephrine reuptake inhibition (NRI). This study evaluated the pharmacokinetics and pharmacodynamics of tapentadol as a potential analgesic with the goal of treating pain in horses.
Annabella D. Lynch, Khursheed R. Mama, Dan S. McKemie, Phillip H. Kass, Heather K. Knych   +4 more
wiley   +1 more source

Breaking the Debilitating Cycle: Pathophysiology, Assessment, and Multimodal Intervention of Secondary Debilitation After Hip Fracture in Older Adults—A Narrative Review

Orthopaedic Surgery, EarlyView.
This article provides a comprehensive overview of the pathophysiological mechanisms underlying “secondary debilitation after hip fracture,” discusses the clinical application of risk assessment tools, and presents a phased, stepwise intervention strategy aimed at interrupting the “vicious cycle.” ABSTRACT Hip fractures pose a serious threat to the ...
Wenyang Xu, Fan Xu, Maoqiang Fan, Yao Liu, Zhe Song   +4 more
wiley   +1 more source