Results 101 to 110 of about 44,701 (229)

Patient Experiences and Preliminary Effects of Virtual Reality Based Pain Treatment in Rheumatoid Arthritis Patients With Persistent Pain Despite Low Disease Activity: A Mixed Method Pilot Study

Musculoskeletal Care, Volume 24, Issue 3, September 2026.
ABSTRACT Objective This study aimed to examine the acceptability, usability, patient perceptions and preliminary effects of a virtual reality (VR) based pain management programme for people with rheumatoid arthritis with persistent pain despite low disease activity.
Stijn J. M. Temmink, Marlou A. Bakker, Demy D. Gerritsen, Mirjam C. Hegeman, Liza de Vries, Peter M. ten Klooster, Christina Bode, Harald E. Vonkeman   +7 more
wiley   +1 more source

The rs10781468 Genetic Polymorphism of the Gαq (GNAQ) Gene Is Associated With Responsiveness to Opioid Analgesics in Patients With Postoperative and Cancer Pain: An Exploratory Study

Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.
In our exploratory hypothesis‐generating study using patients with postoperative pain and cancer pain, for rs10781468 in the GNAQ gene, the minor allele was associated with reduced opioid consumption and an increased pain threshold. ABSTRACT Background G protein–coupled receptors, the largest class of cell surface receptors, are ubiquitously expressed ...
Hiroaki Owada, Daisuke Nishizawa, Tsutomu Mieda, Miki Tsujita, Hideyuki Nakagawa, Shigeki Yamaguchi, Rikuhei Tsuchida, Yaeko Yokoshima, Akira Kitamura, Masakazu Hayashida, Ken‐ichi Fukuda, Tatsuya Ichinohe, Kazutaka Ikeda, Makoto Kurano, Masahiko Sumitani, Kanji Uchida   +15 more
wiley   +1 more source

Management of Pain in the Intensive Care Unit: A Nordic Survey

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 8, September 2026.
ABSTRACT Background Pain is common in intensive care unit (ICU) patients with up to one‐third experiencing pain at rest and even more during mobilization and clinical procedures. This survey aimed to explore physicians' attitudes and preferences regarding pain management in adult ICU patients in the Nordic countries.
Benedikte Kollerup Madsen, Morten Hylander Møller, Stine Estrup, Lone Musaeus Poulsen, Bodil Steen Rasmussen, Kirstine Sylvester Conradsen, Thomas Lass Klitgaard, Asger Granfeldt, Theis Skovsgaard Itenov, Hans Christian Thorsen Meyer, Signe Tellerup Nielsen, Susanne Andi Iversen, Klaus Tjelle Kristiansen, Morten Heiberg Bestle, Kirsten Møller, Peter Hasse Møller Sørensen, Jeppe Veien Nygaard, Kristian Elgaard, Morten Rune Blichfeldt‐Eckhardt, Ann Christine Waarkjær Olsen, Mette Pedersen, Henrik Westy Hoffmeyer, Peter Martin Hansen, Helle Bundgaard, Marcus Ølgaard Møller, Jarl Sigaard, Kim Zillo Rokamp, Anne Craveiro Brøchner, Christoffer Sølling, Mika Valtonen, Anna‐Maria Kuivalainen, Annukka Vahtera, Stepani Bendel, Martin I. Sigurdsson, Per Martin Bådstøløkken, Fredrik Sjövall, Ole Mathiesen, Lars Peter Kloster Andersen   +37 more
wiley   +1 more source

Rebound Pain and Patient Satisfaction With Dexamethasone as an Adjunct for Peripheral Nerve Blocks. A Substudy Based on Two Randomised Clinical Trials

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 8, September 2026.
ABSTRACT Background Peripheral nerve blocks (PNBs) are a cornerstone in postoperative pain management, reducing pain, opioid consumption, and opioid‐related adverse effects. However, the duration of PNBs is limited and might result in rebound pain after block cessation.
Laura B. Madsen, Jakob H. Andersen, Anders K. Nørskov, Janus C. Jakobsen, Ole Mathiesen, Mathias Maagaard   +5 more
wiley   +1 more source

TRPA1 Regulates Fibrosis‐Associated Transcriptional Pathways in Human Lung Epithelial Cells

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.
ABSTRACT Transient receptor potential ankyrin 1 (TRPA1) is a cation channel originally identified in lung fibroblasts and extensively studied in sensory neurons, where it is associated with pain and neurogenic inflammation. We and others have recently shown that TRPA1 is also expressed in lung epithelial cells and that its expression is regulated by ...
Leevi Halonen, Samu Luostarinen, Ida Valjus, Julia Vistbacka, Antti Pemmari, Eeva Moilanen   +5 more
wiley   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Boy in the Barrel: Excruciating Paroxysmal Pain Disorder Associated With an SCN9A Gain‐of‐Function Variant

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT Background and Aims Gain‐of‐function variants in SCN9A, encoding the Nav1.7 sodium channel, cause inherited painful neuropathic disorders. We report a young man with severe childhood‐onset heat‐triggered paroxysmal pain, autonomic dysfunction, skeletal abnormalities, and a de novo SCN9A p.Ile234Thr variant, emphasizing the diagnostic and ...
Pedro Jose Tomaselli, Rodrigo Siqueira Soares Frezatti, Christopher J. Record, Maria Cristina Lopes Schiavoni, Natalia Dominik, Jana Vandrovcova, Mary M. Reilly, Wilson Marques Jr   +7 more
wiley   +1 more source

A TRIP‐nano killer silencing the pain pacemakers

The Journal of Physiology, EarlyView.
Elisabetta Cerbai
wiley   +1 more source

The Burden of Small Fiber Neuropathy: Changes in Pain, Costs, and Quality of Life Before and After Diagnosis

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT Background and Aims Small fiber neuropathy (SFN) is a peripheral neuropathy causing neuropathic pain, reduced quality of life (QoL), and high societal costs. Previous studies assessed these societal costs before a definitive diagnosis was established, leaving it unclear whether diagnostic confirmation affects costs, pain intensity, or QoL ...
Dennis Kool, Margot Geerts, Lloyd Brandts, Merel Kimman, Caroline M. L. Gorissen‐Brouwers, Catharina G. Faber, Ingemar S. J. Merkies, Janneke G. J. Hoeijmakers   +7 more
wiley   +1 more source

Mesotherapy With Lidocaine and Ketamine in Complex Regional Pain Syndrome Type 1: A Randomized Double‐Blind Trial

Pain Practice, Volume 26, Issue 7, September 2026.
ABSTRACT Background Complex regional pain syndrome type 1 (CRPS1) is a disabling pain syndrome whose treatment remains challenging. Mesotherapy is a therapeutic method involving the injection of low doses of active substances through the skin. No studies assessed mesotherapy in CRPS1 patients.
Philippe Lafuma, Laurent Magaud, Amna Abichou‐Klich, Muriel Rabilloud, Julien Wegrzyn, Christian Baude, Pascal Rippert, Myriam Kaou, Julie Haesebaert, Frédéric Rongieras, Chloé Marchand, Carole Dhelens, Olivia Febvey‐Combes   +12 more
wiley   +1 more source