Results 121 to 130 of about 16,227 (258)

The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitment

British Journal of Pharmacology, EarlyView.
Morphine activation of μ receptors causes tolerance through c‐Src activation and β‐arrestin2 recruitment. c‐Src inhibition or degradation reduces β‐arrestin2 recruitment, μ receptor endocytosis, while causing receptor upregulation, all likely contributing to reduced morphine tolerance.
Samuel Singleton, Fraser Nunn, Erika Lace, Álvaro Lorente‐Macías, Rachel Toth, Asier Unciti‐Broceta, Tim G. Hales   +6 more
wiley   +1 more source

Time course of primary and secondary hyperalgesia.

, 2014
A: Time course of the area of secondary hyperalgesia over 24 h after repetitive heat revealed significant secondary hyperalgesia for at least 24 h after heat stimulation. B: Time course of pain ratings increase vs.
Florian Henrich (574922), Arne May (51036), Tim P. Jürgens (297277), Alexander Sawatzki (574921), Walter Magerl (94277)   +4 more
core   +1 more source

TRPM3 regulates fear memory encoding and seizure susceptibility in the lateral amygdala

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose TRPM3 is best known for its role as a peripheral sensor of pain and heat. Recent studies reporting gain‐of‐function TRPM3 mutations in patients with neurodevelopmental and epilepsy‐associated disorders suggest a previously unrecognized role of this channel in the brain.
Attila Gyéresi, Laura Mundrucz, Máté Deák, Angéla Kecskés, Éva Borbély, Viktória Kormos, Balázs Gaszner, Orsolya Mihály, Balázs István Tóth, Joris Vriens, Thomas Voets, Erzsébet Kövesdi, Miklós Kecskés   +12 more
wiley   +1 more source

Neuropathic pain in cerebral palsy and related genetic conditions: A scoping review of prevalence, characteristics, and management

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To map existing evidence on neuropathic pain in cerebral palsy (CP) and related genetic conditions, including prevalence, descriptors, assessment methods, and management. Method Following prospective registration, five databases (Ovid MEDLINE, Embase, CINAHL, Web of Science, Google Scholar) were searched in June 2025.
Aayushi Khillan, Sanya Verma, Hannah Yeomans, Karen Bau, Caitlin Doyle, Monica S. Cooper, David J. Amor, Carolyn Berryman, Adrienne Harvey   +8 more
wiley   +1 more source

Nocebo hyperalgesia: contributions of social observation and body-related cognitive styles

, 2016
Elisabeth Vögtle,1 Birgit Kröner-Herwig,1 Antonia Barke21Department of Clinical Psychology and Psychotherapy, Georg-Elias-Müller-Institute for Psychology, University of Göttingen, Göttingen, 2Department of Psychology, Division of
Vögtle E, Kröner-Herwig B, Vögtle, Elisabeth, Barke, Antonia, Barke A, Kroener-Herwig, Birgit   +5 more
core   +1 more source

1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty

The FEBS Journal, EarlyView.
Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah, Grace Filbertine, Lucy Gill, Asangaedem Akpan, Marie M. Phelan, Helen Louise Wright   +5 more
wiley   +1 more source

Novel targets in headache: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This narrative review summarizes novel applications for the use of calcitonin gene‐related peptide (CGRP)‐targeted therapies that go beyond migraine, the latest updates with respect to targeting pituitary adenylate cyclase‐activating peptide (PACAP) as therapeutic in migraine, as well as exploring other more recently ...
Adriana Della Pietra, Peter J. Goadsby, Carolina Oldoni, Stephen Silberstein, Fred Cohen, Simon Akerman   +5 more
wiley   +1 more source

Scalp Dysesthesia: Emerging Pathophysiologic Insights and Therapeutic Implications

International Journal of Dermatology, EarlyView.
Scalp dysesthesia is a chronic condition diagnosed through exclusion. This scoping review synthesized data from 59 patients to identify recurrent clinical features, comorbidities, and management strategies that may support earlier diagnosis. Emerging patterns suggest that neuronal sensitization may underlie common symptoms.
Aditya K. Gupta, Jaspreet Kaur, Amanda Liddy, Paradi Mirmirani, Vincent Piguet   +4 more
wiley   +1 more source

Nurses' Experiences of Pain Management for Patients With Diagnosed Mental Health Conditions: A Systematic Review

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To synthesise the available evidence related to nurses' pain assessment and management practices for patients with diagnosed mental health conditions. Design Mixed‐methods systematic review. Data Sources Medline, CINAHL, PsycINFO, SPORTDiscus and Psychology and Behavioural Sciences Collection.
Aaron Lapuz Alejandro, Yvonne Middlewick, Seng Giap Marcus Ang, Rosemary Saunders, Irene Ngune   +4 more
wiley   +1 more source

Mast cell stabilizer ketotifen reduces hyperalgesia in a rodent model of surgically induced endometriosis

, 2019
Tian-Hong Zhu,1 Gen Zou,1 Shao-Jie Ding,1 Tian-Tian Li,1 Li-Bo Zhu,1 Jian-Zhang Wang,1 Yong-Xing Yao,2 Xin-Mei Zhang11Department of Obstetrics and Gynecology, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, People’s ...
Yao YX, Ding SJ, Li TT, Zhu LB, Wang JZ, Zhang XM, Zhu TH, Zou G   +7 more
core