Results 111 to 120 of about 16,227 (258)

Disease-modifying rdHSV-CA8* non-opioid analgesic gene therapy treats chronic osteoarthritis pain by activating Kv7 voltage-gated potassium channels

Frontiers in Molecular Neuroscience
Chronic pain is common in our population, and most of these patients are inadequately treated, making the development of safer analgesics a high priority.
Gerald Z. Zhuang, William F. Goins, Munal B. Kandel, Marco Marzulli, Mingdi Zhang, Joseph C. Glorioso, Yuan Kang, Alexandra E. Levitt, Konstantinos D. Sarantopoulos, Konstantinos D. Sarantopoulos, Roy C. Levitt, Roy C. Levitt, Roy C. Levitt, Roy C. Levitt   +13 more
doaj   +1 more source

Remifentanil-induced postoperative hyperalgesia: current perspectives on mechanisms and therapeutic strategies

, 2018
Cristina Santonocito,1 Alberto Noto,2 Claudia Crimi,3 Filippo Sanfilippo1 1Department of Anesthesia and Intensive Care, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), Palermo, Italy; 2Department of Anesthesia and
Noto A, Santonocito C, Crimi C, Sanfilippo F   +3 more
core  

Allodynia and hyperalgesia: review

, 2018
The main purpose was to highlight the problem of hyperalgesia and allodynia. Main anatomic structures, which participate in nociception were mentioned in this article, with pathologic and pathophysiologic changes, that can be caused by hyperalgesia and ...
K. D. Dmytriiev, O. V. Marchuk
core   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Camphor Attenuates Hyperalgesia in Neuropathic Pain Models in Mice

Journal of Pain Research, 2023
Ziyuan Li,1,* Yu Gan,1,* Ting Kang,1,* Yi Zhao,1 Tianguang Huang,2 Yuhao Chen,3 Jin Liu,1 Bowen Ke1 1Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of ...
Li Z, Gan Y, Kang T, Zhao Y, Huang T, Chen Y, Liu J, Ke B   +7 more
doaj  

Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms

, 1991
1. Psychophysical studies were made, in humans, of the sensory characteristics and underlying mechanisms of the hyperalgesia (often termed “secondary hyperalgesia”) that occurs in uninjured skin surrounding a local cutaneous injury. The hyperalgesia was
E. F. Tsai, C. N. Shain, R. H. LaMotte, D. A. Simone   +3 more
core   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Traumatic osteoarthritis-induced persistent mechanical hyperalgesia in a rat model of anterior cruciate ligament transection plus a medial meniscectomy

, 2017
Hsiao-Chien Tsai,1–3 Ta-Liang Chen,2–4 Yu-Pin Chen,5 Ruei-Ming Chen1,3,6 1Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan; 2Department of Anesthesiology, Taipei Medical University ...
Chen TL, Chen YP, Chen RM, Tsai HC
core  

Targeting peroxynitrite production in a model of persistent temporomandibular disorder comorbid with migraine

British Journal of Pharmacology, EarlyView.
Background and Purpose The persistence of temporomandibular disorders (TMDs), particularly myogenous, in a person with migraine can lead to exacerbated clinical outcomes and limited response to treatment. The pro‐nociceptive reactive nitroxidative species, peroxynitrite, is involved in migraine mechanisms, but little is known of its role in this ...
Simon Akerman, Ana Belen Salinas‐Abarca, Wei Guo, Daniela Salvemini, Marcela Romero‐Reyes   +4 more
wiley   +1 more source

Toll-like receptor 4 deficient mice do not develop remifentanil-induced mechanical hyperalgesia

, 2018
Background: Drugs with antagonistic actions on the Toll-like receptor 4 (Tlr4), such as naloxone at ultra low doses, have been used to inhibit opioid-induced hyperalgesia in rodents suggesting the involvement of this receptor and pathway on opioid ...
Aguado Domínguez, Delia, Álvarez Gómez De Segura, Ignacio, Delia Aguado, Ignacio A. Gómez de Segura, Bustamante Domínguez, Rocío, Rocío Bustamante   +5 more
core   +1 more source