Results 131 to 140 of about 44,701 (229)

Verbal modeling, counterconditioning, and operant conditioning are effective in nocebo hyperalgesia attenuation. [PDF]

Pain
Rubanets D, Łaska I, Kłosowska J, Bąbel P, Bajcar EA.   +4 more
europepmc   +1 more source

Complex Contributions of Methylglyoxal to Pain, Axon Degeneration, and Diabetic Peripheral Neuropathy

Journal of Neurochemistry, Volume 170, Issue 8, August 2026.
This work reviews how the metabolic by‐product methylglyoxal may contribute to the development of diabetic peripheral neuropathy (DPN), a common complication of diabetes characterized by nerve damage and chronic pain in the extremities. In diabetes, methylglyoxal levels rise due to increased glucose metabolism and reduced detoxification capacity. While
Gentry Totta‐Griese, Douglas E. Wright
wiley   +1 more source

The Role of the Gut Microbiota in Functional Recovery after Peripheral Nerve Injury: A Narrative Review. [PDF]

Orthop Rev (Pavia)
Mueller MK, Rousseau SR, Hark GM, Shaffer LR, Rizvanović BF, Nuelle JAV.   +5 more
europepmc   +1 more source

Therapeutic potential of spexin in diabetic neuropathy: Insights from in vitro and in vivo models

Experimental Physiology, Volume 111, Issue 8, Page 3800-3817, 1 August 2026.
Abstract The present study investigated the therapeutic potential of spexin (SPX) on both in vitro and in vivo models of diabetic neuropathy (DN). A total of 40 male BALB/c mice were randomly allocated into four experimental groups (n = 10 per group): a normoglycaemic control, an untreated DN group and two SPX treatment groups (DN+SPX‐12.5 and DN+SPX ...
Mehmet Refik Bahar, Seval Ulku Orhan, Cigdem Tekin, Asli Taslidere, Mete Ozcan, Suat Tekin   +5 more
wiley   +1 more source

<i>Trans</i>-Chalcone Reduces Inflammation and Pain Triggered by Superoxide Anion: Neuronal and Non-Neuronal Mechanisms. [PDF]

J Inflamm Res
Piva M, Manchope MF, Barbosa-Costa F, Bianchini BHS, Andrade KC, Silva LC, Calixto-Campos C, Rasquel-Oliveira FS, Fattori V, Zarpelon-Schutz AC, Camilios-Neto D, Borghi SM, Casagrande R, Verri WA.   +13 more
europepmc   +1 more source

Pharmacology, Medicinal Chemistry, and Therapeutic Potential of Imidazoline Receptor Ligands

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Building on the excellent review article by Dardonville and Rozas (2004), this paper summarizes the most representative ligands of imidazoline receptors (IR; I1, I2, and I3) and updates their pharmacological profiles. Although not exhaustive, it provides a solid starting point for understanding the significance of I2 IRs as promising therapeutic ...
Maria‐Eleni Kouridaki, Mercè Pallàs, Carmen Escolano   +2 more
wiley   +1 more source

Molecular Docking and Experimental Evaluation of Trolox and Neocuproine in Targeting Neuroinflammation in Neuropathic Pain Model. [PDF]

J Biochem Mol Toxicol
Yaman S, Akcay G, Yesilyurt F, Yildirim M.   +3 more
europepmc   +1 more source

Voltage-gated sodium channel 1.8 contributes to hyperalgesia induced by the coexistence of anxiety and remifentanil exposure. [PDF]

Korean J Pain
Cai J, Chen L, Wang Y, Ye J, Xu Z, Gao L, Zhou Z, Sun J.   +7 more
europepmc   +1 more source

Protectin DX reduces inflammatory pain initiated by superoxide anion in mice: targeting leukocyte recruitment, oxidative stress, cytokine production and TRPV1⁺ nociceptive sensory neuron activation. [PDF]

Inflamm Res
Carneiro JA, Bianchini BHS, Martelossi-Cebinelli G, Artero NA, Maximiano TKE, Franciosi A, Dionisio AM, Yaekashi KM, Carvalho TT, da Silva MDV, Rasquel-Oliveira FS, Zanoveli JM, Fattori V, Casagrande R, Verri WA.   +14 more
europepmc   +1 more source

Evaluating FABP5 as a Therapeutic Target for Pain Management. [PDF]

Eur J Pain
Warren W, Osborn M, Kaczocha M, Yates A, O'Sullivan S.   +4 more
europepmc   +1 more source