Results 41 to 50 of about 16,227 (258)

Descending serotonergic controls regulate inflammation-induced induced mechanical sensitivity and methyl-CpG-binding protein 2 phosphorylation in the rat superficial dorsal horn [PDF]

, 2008
Background: Regulation of pain states is, in part, dependent upon plastic changes in neurones within the superficial dorsal horn. There is also compelling evidence that pain states are under the control of descending projections from the brainstem. While
Geranton, SM, Hunt Stephen P, Vincenza Fratto, Fratto Vincenza, Fratto, V, Tochiki Keri K, Géranton Sandrine M, Hunt, SP, Sandrine M Géranton, Keri K Tochiki, Stephen P Hunt, Tochiki, KK   +11 more
core   +1 more source

Toward Perception‐Native Electronic Skin: Bio‐Inspired In‐/Near‐Sensor and Neuromorphic Computing for Humanoid Robots

Advanced Materials Technologies, EarlyView.
Dense tactile streams from across the humanoid body converge on collide in a central wiring and data bottleneck. By relocating computation closer to and then into the skin itself, near‐ and in‐sensor architectures, together with neuromorphic computing, chart a path toward perception‐native electronic skin, in which the conversion of stimulus into ...
Mijin Kim, Chang‐Jae Beak, Jiyoung Park, Youngdo Jung, Sunjong Oh, Sin‐Hyung Lee, Bo‐Yeon Lee   +6 more
wiley   +1 more source

Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients. [PDF]

, 2011
Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic ...
Maihöfner Christian, Magerl Walter, Zhu, Jihong, Cascorbi Ingolf, Roman Rolke, Maihöfner, Christian, Binder Andreas, Treede, Rolf-Detlef, Faltraco, Frank, Flor, Herta, Rolf-Detlef Treede, Richter Helmut, Thomas R. Tölle, Nurcan Uçeyler, Huge, Volker, Mike Ufer, Christian Maihöfner, May, Denisa, Andrea Scherens, Uçeyler, Nurcan, Ralf Baron, May Denisa, Huge Volker, Cascorbi, Ingolf, Scherens, Andrea, Ufer, Mike, Gunnar Wasner, Binder, Andreas, Jihong Zhu, Herta Flor, Volker Huge, Helmut Richter, Tölle, Thomas R., Maier Christoph, Maier, Christoph, Thomas R Tölle, Tölle Thomas R., Zhu Jihong, Achim Berthele, Gierthmühlen Janne, Baron Ralf, Faltraco Frank, Magerl, Walter, Andreas Binder, Gierthmühlen, Janne, Christoph Maier, Richter, Helmut, Flor Herta, Wasner Gunnar, Denisa May, Scherens Andrea, Baron, Ralf, Üçeyler Nurcan, Haenisch Sierk, Rolke, Roman, Berthele Achim, Frank Faltraco, Ingolf Cascorbi, Berthele, Achim, Treede Rolf-Detlef, Ufer Mike, Haenisch, Sierk, Wasner, Gunnar, Janne Gierthmühlen, Sierk Haenisch, Rolke Roman, Walter Magerl   +66 more
core   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

Pain profiles in pancreatic cancer and chronic pancreatitis: a multicenter cross-sectional analysis

Frontiers in Pain Research
IntroductionAbnormal pain processing has been associated with impaired patient-reported outcomes (PROMs) in chronic pancreatitis (CP), but its clinical relevance in pancreatic ductal adenocarcinoma (PDAC) remains unclear.
Marie-Theres Kassik, Mahya Faghih, Mahya Faghih, Conrad Bandhauer, Josefine Jäger, Sophie Rauschenberg, Søren S. Olesen, Daniel A. Laheru, Lei Zheng, Anna E. Phillips, Dhiraj Yadav, Jonas Rosendahl, Vikesh K. Singh, Vikesh K. Singh, Asbjørn M. Drewes, Marko Damm   +15 more
doaj   +1 more source

Depletion of noradrenaline inhibits electrically-evoked pain in the skin of the human forearm [PDF]

, 2008
Guanethidine displaces noradrenaline from sympathetic varicosities, and blocks sympathetic noradrenergic neurotransmission by inhibiting the release of noradrenaline from depleted neural stores. The aim of this study was to determine whether depletion of
Drummond, P.D.
core  

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Supraspinal contributions to hyperalgesia [PDF]

Proceedings of the National Academy of Sciences, 1999
Tissue injury is associated with sensitization of nociceptors and subsequent changes in the excitability of central (spinal) neurons, termed central sensitization. Nociceptor sensitization and central sensitization are considered to underlie, respectively, development of primary hyperalgesia and secondary hyperalgesia.
M O, Urban, G F, Gebhart
openaire   +2 more sources

Naloxone antagonizes the local antihyperalgesic effect of fentanyl in burnt skin of healthy humans [PDF]

, 2007
The aim of this study was to investigate local opioid effects in the inflamed skin of healthy human volunteers. To induce inflammation, the circular tip of a 10-mm-diameter probe was heated to 48°C and applied for 120 seconds to a site on each forearm of
Hammond, G.R., Drummond, P.D., Robertson, L.   +2 more
core