Results 21 to 30 of about 44,475 (226)

Influence of Working Length on Post-operative Pain after Single or Two-visit Endodontic Treatment: A Randomised Clinical Trial [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: Microorganisms in the cemental canal can lead to the development of periapical lesions and its mechanical removal by means of overinstrumentation may be more favourable for the success of endodontic treatment.
Alessandra Manchini Cardoso Tarallo, Felipe De Souza Matos, Eduardo Bresciani, Luiz Renato Paranhos, Carlos Henrique Ribeiro Camargo   +4 more
doaj   +1 more source

Rationale for analgesia to prevent postoperative hyperalgesia in children, according to the morphological study of skin in the wound

Медицина болю, 2021
In the article, morphological changes of skin in the area of postoperative wound are displayed. It was discovered that continuous infusion of high-dose fentanyl (10–20 mcg/kg/h) for analgesia in the early postoperative period in children operated on for ...
Dmytro Dmytriiev , Oleksandr Marchuk , Olena Kovalchuk   +2 more
doaj   +1 more source

Trigeminal-Rostral Ventromedial Medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injury

Molecular Pain, 2012
Background Our previous studies have shown that complete Freund’s adjuvant (CFA)-induced masseter inflammation and microinjection of the pro-inflammatory cytokine interleukin-1β (IL-1β) into the subnucleus interpolaris/subnucleus caudalis transition zone
Chai Bryan, Guo Wei, Wei Feng, Dubner Ronald, Ren Ke   +4 more
doaj   +1 more source

Catecholaminergic and Cholinergic Systems Mediate Beneficial Effect of Vortioxetine on Diabetes-Induced Neuropathic Pain

Biomedicines, 2023
The therapeutic potential of vortioxetine on mechanical hyperalgesia/allodynia was investigated in rats with streptozotocin-induced diabetes, and its possible mechanism of action was elucidated in this study.
Nazlı Turan Yücel, Ümmühan Kandemir, Umut İrfan Üçel, Ümide Demir Özkay, Özgür Devrim Can   +4 more
doaj   +1 more source

Contribution of TRPV1 Receptor–Expressing Fibers to Spinal Ventral Root After-Discharges and Mechanical Hyperalgesia in a Spared Nerve Injury (SNI) Rat Model

Journal of Pharmacological Sciences, 2013
Neuropathic pain induces allodynia and hyperalgesia. In the spared nerve injury (SNI) model, marked mechanical hyperalgesia is manifested as prolongation of the duration of paw withdrawal after pin stimulation.
Shohei Yamamoto, Masahiro Ohsawa, Hideki Ono   +2 more
doaj   +1 more source

Oromucosal Administration of a Cannabidiol-Enriched Cannabis sp. Extract for 2 Weeks Moderately Reduces Cold Hyperalgesia in Rats With Neuropathic Pain. [PDF]

Eur J Pain
ABSTRACT Background Chronic neuropathic pain (CNP) involves complex interactions between resident and peripheral immune cells, as well as modulation of the endocannabinoid system. Cannabis‐based products have emerged as promising therapeutic options, but their effects on immune cells remain unclear.
Campos RMP, Conde L, Aguiar A, Sampaio L, de Melo Reis RA, Pimentel-Coelho PM.   +5 more
europepmc   +2 more sources

Shifting the Balance: How Top-Down and Bottom-Up Input Modulate Pain via the Rostral Ventromedial Medulla

Frontiers in Pain Research, 2022
The sensory experience of pain depends not only on the transmission of noxious information (nociception), but on the state of the body in a biological, psychological, and social milieu.
Qiliang Chen, Mary M. Heinricher
doaj   +1 more source

Evaluation of Recombinant Botulinum Neurotoxin Type A1 Efficacy in Peripheral Inflammatory Pain in Mice

Frontiers in Molecular Neuroscience, 2022
Well-established efficacy of botulinum neurotoxin type A (BoNT/A) in aesthetic dermatology and neuromuscular hyperactivity disorders relies on canonical interruption of acetylcholine neurotransmission at the neuromuscular junction at the site of the ...
Beatrice Oehler, Beatrice Oehler, Cindy Périer, Vincent Martin, Amy Fisher, Stéphane Lezmi, Mikhail Kalinichev, Stephen B. McMahon   +7 more
doaj   +1 more source

Gabapentin Prevents Oxaliplatin-Induced Mechanical Hyperalgesia in Mice

Journal of Pharmacological Sciences, 2014
.: Oxaliplatin, a platinum-based chemotherapy drug, frequently causes acute and chronic peripheral neuropathies including mechanical hyperalgesia. These adverse effects hinder anticancer therapy with the drug.
Masahiro Ohsawa, Saki Otake, Tomoyasu Murakami, Shohei Yamamoto, Toshiaki Makino, Hideki Ono   +5 more
doaj   +1 more source

Dual Inhibition of FAAH and MAGL Counteracts Migraine-like Pain and Behavior in an Animal Model of Migraine

Cells, 2021
The endocannabinoid system exerts an important role in pain processing and modulation. Modulation of the system with hydrolase inhibitors of anandamide (AEA) or 2-arachidonyl glycerol (2-AG) has proved effective in reducing migraine-like features in ...
Rosaria Greco, Chiara Demartini, Miriam Francavilla, Anna Maria Zanaboni, Cristina Tassorelli   +4 more
doaj   +1 more source