Results 21 to 30 of about 16,227 (258)

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

How Negative Experience Influences the Brain: A Comprehensive Review of the Neurobiological Underpinnings of Nocebo Hyperalgesia

Frontiers in Neuroscience, 2021
This comprehensive review summarizes and interprets the neurobiological correlates of nocebo hyperalgesia in healthy humans. Nocebo hyperalgesia refers to increased pain sensitivity resulting from negative experiences and is thought to be an important ...
Mia A. Thomaidou, Mia A. Thomaidou, Kaya J. Peerdeman, Kaya J. Peerdeman, Melissa I. Koppeschaar, Andrea W. M. Evers, Andrea W. M. Evers, Andrea W. M. Evers, Andrea W. M. Evers, Dieuwke S. Veldhuijzen, Dieuwke S. Veldhuijzen   +10 more
doaj   +1 more source

The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation [PDF]

, 2005
Therapies directed against tumour necrosis factor (TNF) are effective for the treatment of rheumatoid arthritis and reduce pain scores in this condition.
Inglis, JJ, Lees, DM, Ahuva Nissim, Nissim, A, Bruce L Kidd, Kidd, BL, Julia J Inglis, Delphine M Lees, Hunt, SP, Chernajovsky, Y, Stephen P Hunt, Yuti Chernajovsky   +11 more
core   +1 more source

Trigeminal-Rostral Ventromedial Medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injury

Molecular Pain, 2012
Background Our previous studies have shown that complete Freund’s adjuvant (CFA)-induced masseter inflammation and microinjection of the pro-inflammatory cytokine interleukin-1β (IL-1β) into the subnucleus interpolaris/subnucleus caudalis transition zone
Chai Bryan, Guo Wei, Wei Feng, Dubner Ronald, Ren Ke   +4 more
doaj   +1 more source

Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation [PDF]

, 2011
Background Cytochrome-P450 (CYP450) epoxygenases metabolise arachidonic acid (AA) into four different biologically active epoxyeicosatrienoic acid (EET) regioisomers.
Geisslinger, Gerd, Gerd Geisslinger, Brandes, Ralf P., Brandes, Ralf, Michael J Fischer, Fleming, Ingrid, Scholich, Klaus, Woolf Clifford J, Ralf P Brandes, Clifford J Woolf, Fleming Ingrid, Reeh, Peter Werner, Brenneis Christian, Fischer, Michael, Coste Ovidiu, Coste, Ovidiu, Brandes Ralf P, Kai Altenrath, Reeh Peter W, Christian Brenneis, Scholich Klaus, Sisignano, Marco, Reeh, Peter W., Altenrath Kai, Ingrid Fleming, Peter W Reeh, Woolf, Clifford J., Angioni Carlo, Geisslinger Gerd, Angioni, Carlo Federico, Klaus Scholich, Brenneis, Christian, Ovidiu Coste, Carlo Angioni, Sisignano Marco, Marco Sisignano, Fischer, Michael J., Fischer Michael J, Altenrath, Kai, Angioni, Carlo   +39 more
core   +3 more sources

Peripheral Mechanism of Hyperalgesia : Sensitization of Nociceptors [PDF]

, 1997
1997-11The peripheral mechanism of hyperalgesia is considered to be the result of nociceptor sensitization. As possible agents causing nociceptor sensitization, bradykinin, histamine, prostaglandin (PG)s, protons and nerve growth factor are evaluated ...
MIZUMURA, KAZUE
core   +1 more source

Susceptibility to Nocebo Hyperalgesia, Dispositional Optimism, and Trait Anxiety as Predictors of Nocebo Hyperalgesia Reduction [PDF]

, 2023
OBJECTIVES: The current paper explores the psychological predictors of nocebo hyperalgesia and whether the reduction of nocebo hyperalgesia can be predicted by susceptibility to nocebo hyperalgesia and psychological characteristics.
Dusseldorp, E., Meijer, Simone, Dusseldorp, Elise, Karacaoglu, Merve, van Middendorp, Henriët, Simone Meijer, Veldhuijzen, DS, Kaya J. Peerdeman, Merve Karacaoglu, Andrea W.M. Evers, Meijer, S., Karacaoglu, M, Dusseldorp, Elise (author), Karacaoglu, M., van, Middendorp H, Evers, A.W.M., Dieuwke S. Veldhuijzen, Karin B. Jensen, Jensen, Karin B. (author), Peerdeman, K.J., Evers, AWM, Henriët van Middendorp, Veldhuijzen, Dieuwke S., Meijer, Simone (author), Middendorp, H. van, Meijer, S, Karacaoglu, Merve (author), Peerdeman, Kaya J. (author), Evers, A.W.M. (author), van Middendorp, Henriët (author), Jensen, Karin B., Veldhuijzen, D.S., Jensen, KB, Jensen, K.B., Peerdeman, KJ, Elise Dusseldorp, Peerdeman, Kaya J., Dusseldorp, E.M.L., Dusseldorp, E, Veldhuijzen, Dieuwke S. (author)   +39 more
core   +2 more sources

Contribution of TRPV1 Receptor–Expressing Fibers to Spinal Ventral Root After-Discharges and Mechanical Hyperalgesia in a Spared Nerve Injury (SNI) Rat Model

Journal of Pharmacological Sciences, 2013
Neuropathic pain induces allodynia and hyperalgesia. In the spared nerve injury (SNI) model, marked mechanical hyperalgesia is manifested as prolongation of the duration of paw withdrawal after pin stimulation.
Shohei Yamamoto, Masahiro Ohsawa, Hideki Ono   +2 more
doaj   +1 more source

Analgesic and Anti-Inflammatory Effects of the Synthetic Neurosteroid Analogue BNN27 during CFA-Induced Hyperalgesia

Biomedicines, 2021
Dehydroepiandrosterone (DHEA), an adrenal and neurosteroid hormone with strong neuroprotective and immunomodulatory properties, and ligand for all high-affinity neurotrophin tyrosine kinase receptors (Trk), also exerts important effects on hyperalgesia ...
Smaragda Poulaki, Olga Rassouli, George Liapakis, Achille Gravanis, Maria Venihaki   +4 more
doaj   +1 more source

The role of cGMP and PKG-I in spinal nociceptive processing [PDF]

, 2005
First paragraph (this article has no abstract) Persistent stimulation of nociceptors results in sensitization of nociceptive sensory neurons, which is associated with hyperalgesia and allodynia.
Geisslinger, Gerd, Schmidtko, Achim, Gerd Geisslinger, Ruth, Peter, Niederberger, Ellen, Achim Schmidtko, Irmgard Tegeder, Franz Hofmann, Hofmann, Franz, Peter Ruth, Ellen Niederberger, Tegeder, Irmgard   +11 more
core   +1 more source