Results 11 to 20 of about 44,701 (229)

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Nalmefene vs. dexmedetomidine for prevention of postoperative hyperalgesia in patients undergoing laparoscopic gynecological surgery with remifentanil infusion: A randomized double-blind controlled trial

Frontiers in Pharmacology, 2023
Intraoperative remifentanil infusion may paradoxically induce post-surgical hyperalgesia. Dexmedetomidine reportedly reduces opioid-induced hyperalgesia. Nalmefene selectively reverses several side-effects of opioids without impairing analgesia.
Zhen Jia, Zhen Jia, Yi Chen, Yi Chen, Tianyu Gao, Tianyu Gao, Yuan Yuan, Yuan Yuan, Yuxin Zheng, Yuxin Zheng, Yegong Xie, Yegong Xie, Guolin Wang, Guolin Wang, Yonghao Yu, Yonghao Yu, Linlin Zhang, Linlin Zhang   +17 more
doaj   +1 more source

How Negative Experience Influences the Brain: A Comprehensive Review of the Neurobiological Underpinnings of Nocebo Hyperalgesia

Frontiers in Neuroscience, 2021
This comprehensive review summarizes and interprets the neurobiological correlates of nocebo hyperalgesia in healthy humans. Nocebo hyperalgesia refers to increased pain sensitivity resulting from negative experiences and is thought to be an important ...
Mia A. Thomaidou, Mia A. Thomaidou, Kaya J. Peerdeman, Kaya J. Peerdeman, Melissa I. Koppeschaar, Andrea W. M. Evers, Andrea W. M. Evers, Andrea W. M. Evers, Andrea W. M. Evers, Dieuwke S. Veldhuijzen, Dieuwke S. Veldhuijzen   +10 more
doaj   +1 more source

Trigeminal-Rostral Ventromedial Medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injury

Molecular Pain, 2012
Background Our previous studies have shown that complete Freund’s adjuvant (CFA)-induced masseter inflammation and microinjection of the pro-inflammatory cytokine interleukin-1β (IL-1β) into the subnucleus interpolaris/subnucleus caudalis transition zone
Chai Bryan, Guo Wei, Wei Feng, Dubner Ronald, Ren Ke   +4 more
doaj   +1 more source

Contribution of TRPV1 Receptor–Expressing Fibers to Spinal Ventral Root After-Discharges and Mechanical Hyperalgesia in a Spared Nerve Injury (SNI) Rat Model

Journal of Pharmacological Sciences, 2013
Neuropathic pain induces allodynia and hyperalgesia. In the spared nerve injury (SNI) model, marked mechanical hyperalgesia is manifested as prolongation of the duration of paw withdrawal after pin stimulation.
Shohei Yamamoto, Masahiro Ohsawa, Hideki Ono   +2 more
doaj   +1 more source

Analgesic and Anti-Inflammatory Effects of the Synthetic Neurosteroid Analogue BNN27 during CFA-Induced Hyperalgesia

Biomedicines, 2021
Dehydroepiandrosterone (DHEA), an adrenal and neurosteroid hormone with strong neuroprotective and immunomodulatory properties, and ligand for all high-affinity neurotrophin tyrosine kinase receptors (Trk), also exerts important effects on hyperalgesia ...
Smaragda Poulaki, Olga Rassouli, George Liapakis, Achille Gravanis, Maria Venihaki   +4 more
doaj   +1 more source

Gabapentin Prevents Oxaliplatin-Induced Mechanical Hyperalgesia in Mice

Journal of Pharmacological Sciences, 2014
.: Oxaliplatin, a platinum-based chemotherapy drug, frequently causes acute and chronic peripheral neuropathies including mechanical hyperalgesia. These adverse effects hinder anticancer therapy with the drug.
Masahiro Ohsawa, Saki Otake, Tomoyasu Murakami, Shohei Yamamoto, Toshiaki Makino, Hideki Ono   +5 more
doaj   +1 more source

Characterization of migraineurs presenting interictal widespread pressure hyperalgesia identified using a tender point count: a cross-sectional study

The Journal of Headache and Pain, 2017
Background Migraineurs exhibit pain hypersensitivity throughout the body during and between migraine headaches. Migraine is classified as a central sensitivity syndrome, typified by fibromyalgia showing widespread pressure hyperalgesia determined by a ...
Toshihide Toriyama, Tetsuyoshi Horiuchi, Kazuhiro Hongo   +2 more
doaj   +1 more source

Differential involvement of reactive oxygen species in a mouse model of capsaicin-induced secondary mechanical hyperalgesia and allodynia

Molecular Pain, 2017
Intradermally injected capsaicin induces secondary mechanical hyperalgesia and allodynia outside the primary (i.e., capsaicin-injected) site. This secondary mechanical hypersensitivity is attributed to central sensitization in which reactive oxygen ...
Jun-Ho La, Jigong Wang, Alice Bittar, Hyun Soo Shim, Chilman Bae, Jin Mo Chung   +5 more
doaj   +1 more source

Intrathecal injections of non-peptide oxytocin receptor agonists, WAY 267,464 and TC OT 39, induce significant anti-hyperalgesia in both male and female rats with inflammatory pain [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Hyperalgesia is a clinical condition related to chronic pain in which patients experience increased nociceptive sensitivity. Intrathecal oxytocin has been shown to induce significant anti-hyperalgesia in both rodents and humans. However, in
Lok-Hi Chow, Yuan-Hao Chen, Ying-Jie Chen, Pin-Chen Lin, Eagle Yi-Kung Huang   +4 more
doaj   +1 more source