Results 11 to 20 of about 57,963 (312)

Hypercapnia increases ACE2 expression and pseudo-SARS-CoV-2 entry in bronchial epithelial cells by augmenting cellular cholesterol

Frontiers in Immunology, 2023
Patients with chronic lung disease, obesity, and other co-morbid conditions are at increased risk of severe illness and death when infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Fei Chen, Aiko Matsuda, G. R. Scott Budinger, G. R. Scott Budinger, Peter H. S. Sporn, Peter H. S. Sporn, S. Marina Casalino-Matsuda   +6 more
doaj   +1 more source

Respiratory Muscle Function Tests and Diaphragm Ultrasound Predict Nocturnal Hypoventilation in Slowly Progressive Myopathies

Frontiers in Neurology, 2021
Introduction: In slowly progressive myopathies, diaphragm weakness early manifests through sleep-related hypoventilation as reflected by nocturnal hypercapnia.
Jens Spiesshoefer, Jens Spiesshoefer, Riccarda Lutter, Hans-Joachim Kabitz, Carolin Henke, Simon Herkenrath, Simon Herkenrath, Winfried Randerath, Winfried Randerath, Peter Young, Michael Dreher, Dennis Görlich, Matthias Boentert, Matthias Boentert   +13 more
doaj   +1 more source

Sub-cortical and brainstem sites associated with chemo-stimulated increases in ventilation in humans [PDF]

, 2010
We investigated the neural basis for spontaneous chemo-stimulated increases in ventilation in awake, healthy humans. Blood oxygen level dependent (BOLD) functional MRI was performed in nine healthy subjects using T2weighted echo planar imaging.
Ackland, Akopyan, Banzett, Bertrand, Bianchi, Brannan, Cavanna, Cechetto, Chamberlin, Chamberlin, Chen, Colebatch, Corfield, Corfield, Critchley, Dick, Douglas, Douglas, Douglas R. Corfield, Duvernoy, Duvernoy, Evans, Evans, Fink, Fink, Friston, Friston, Gandevia, Gaytan, Gray, Haines, Harper, Herbert, Heywood, Hugo D. Critchley, Isaev, Kevin Murphy, Kjaer, Koos, Kubin, Kumar, Lavezzi, Leanne C. McKay, Macey, McKay, McKay, McKay, Middleton, Mink, Nathan, Pattinson, Peiffer, Plum, Plum, Ramsay, Richard S.J. Frackowiak, Schmahmann, Schwarzacher, Severinghaus, Shea, Skatrud, Smith, Smith, Talairach, Wenninger, Worsley, Xu, Yokota   +67 more
core   +2 more sources

Age Related Changes in Cerebrovascular Reactivity and Its Relationship to Global Brain Structure [PDF]

, 2015
ACKNOWLEDGMENTS This study was funded by Alzheimer’s Research UK (ARUK) and the Aberdeen Biomedical Imaging Centre, University of Aberdeen. GDW, ADM and CS are part of the SINASPE collaboration (Scottish Imaging Network - A Platform for Scientific ...
Ahearn, Trevor S., Cameron, George G., Murray, Alison D., Schwarzbauer, Christian, Waiter, Gordon D.   +4 more
core   +1 more source

Hypercapnia alters stroma-derived Wnt production to limit β-catenin signaling and proliferation in AT2 cells

JCI Insight, 2023
Persistent symptoms and radiographic abnormalities suggestive of failed lung repair are among the most common symptoms in patients with COVID-19 after hospital discharge. In mechanically ventilated patients with acute respiratory distress syndrome (ARDS)
Laura A. Dada, Lynn C. Welch, Natalia D. Magnani, Ziyou Ren, Hyebin Han, Patricia L. Brazee, Diego Celli, Annette S. Flozak, Anthea Weng, Mariana Maciel Herrerias, Vitalii Kryvenko, István Vadász, Constance E. Runyan, Hiam Abdala-Valencia, Masahiko Shigemura, S. Marina Casalino-Matsuda, Alexander V. Misharin, G.R. Scott Budinger, Cara J. Gottardi, Jacob I. Sznajder   +19 more
doaj   +1 more source

Effects of hypercapnia and NO synthase inhibition in sustained hypoxic pulmonary vasoconstriction

Respiratory Research, 2012
Background Acute respiratory disorders may lead to sustained alveolar hypoxia with hypercapnia resulting in impaired pulmonary gas exchange. Hypoxic pulmonary vasoconstriction (HPV) optimizes gas exchange during local acute (0-30 min), as well as ...
Ketabchi Farzaneh, Ghofrani Hossein A, Schermuly Ralph T, Seeger Werner, Grimminger Friedrich, Egemnazarov Bakytbek, Shid-Moosavi S Mostafa, Dehghani Gholam A, Weissmann Norbert, Sommer Natascha   +9 more
doaj   +1 more source

Hypercapnia attenuates ventilator-induced lung injury through vagus nerve activation [PDF]

Acta Cirúrgica Brasileira, 2019
Purpose: To investigate the role of vagus nerve activation in the protective effects of hypercapnia in ventilator-induced lung injury (VILI) rats.
Wenfang Xia, Guang Li, Zhou Pan, Qingshan Zhou   +3 more
doaj   +1 more source

Hypercapnia Effects on Lung Function. [PDF]

Compr Physiol
CO2 is a signaling molecule that disrupts alveolar fluid clearance and ion transport, impairs alveolar repair, and promotes mitochondrial and endoplasmic reticulum dysfunction. It suppresses innate immunity, host defense, and inflammation, while increasing airway contractility.
Choi S, Dada LA, Sznajder JI.
europepmc   +2 more sources

Ventilatory Phenotypes among Four Strains of Adult Rats. [PDF]

, 2002
Our purpose in this study was to identify different ventilatory phenotypes among four different strains of rats. We examined 114 rats from three in-house, inbred strains and one outbred strain: Brown Norway (BN;n = 26), Dahl salt-sensitive (n = 24), Fawn-
Dwinell, Melinda R., Forster, Hubert, Hodges, Matthew, Hogan, Genevieve E., Papanek, Paula   +4 more
core   +2 more sources

Effects of Permissive Hypercapnia on Laparoscopic Surgery for Rectal Carcinoma

Gastroenterology Research and Practice, 2019
Background. Permissive hypercapnia has been recommended during the treatment of chronic diseases; however, there are insufficient clinical data to investigate the feasibility of permissive hypercapnia in relatively long-term surgeries such as ...
Lei Wang, Lina Yang, Jing Yang, Shiqiang Shan   +3 more
doaj   +1 more source