Results 111 to 120 of about 180,738 (304)

The Role and Therapeutic Potential of Voltage‐Gated Potassium Channel Kv1.3 in Metabolism‐Related Disorders

iNew Medicine, EarlyView.
ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen, Junda Liu, Xixi Chen, Shi Chen, Yuanyuan Tian, Baoming Wu, Fengxia Yan   +6 more
wiley   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Familial Hypercholesterolemia

Heart Views, 2021
openaire   +3 more sources

Blood cholesterol levels of hypercholesterolemic rat (Rattus norvegicus) after VCO treatment [PDF]

, 2009
Abstrak. Harini M, Astirin OP. 2009. Kadar kolesterol darah tikus putih (Rattus norvegicus) hiperkolesterolemik setelah perlakuan VCO. Nusantara Bioscience 1: 53-58.
ASTIRIN, OKID PARAMA, HARINI, MARTI
core   +2 more sources

Lipid Profile Alterations Across Coronary Heart Disease, Metabolic Syndrome, and Nephrotic Syndrome

Journal of Clinical Laboratory Analysis, EarlyView.
CHD, MetS, and NS exhibit distinct dyslipidemia patterns. TC, TG, ApoB, ApoE, and sdLDL‐C are key markers for disease differentiation. This study found that elevated TC and sdLDL‐C were key pathogenic factors in CHD. In contrast, TG and ApoB played significant roles in the pathogenesis of MetS.
Shudong Tan, Tianji Qu, Jing Ai, Yaoyang Fu   +3 more
wiley   +1 more source

Association Between Gas‐Free Cerebrovascular Reactivity (CVR) and Cognitive Function in Older Adults With a High Risk for Vascular Dementia

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Vascular cognitive impairment and dementia (VCID) is the second leading cause of dementia. Cerebrovascular reactivity (CVR) is a promising biomarker for VCID. However, CVR is not commonly measured in clinical practice due to logistical difficulties in applying a hypercapnia challenge during MR imaging. Purpose To investigate whether
Fariba Badrzadeh, Elham Karimigharighi, Huajun Liang, Andrew Chan, Linda Chang, Peiying Liu   +5 more
wiley   +1 more source

Pulsatility Assessment of Cerebral Perforating Arteries Using Submillimeter‐Resolution Dual‐VENC Phase‐Contrast MRI at 3T

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Dysfunction of cerebral perforating arteries is a major contributor to cerebral small vessel disease. Developing a reliable MRI technique for assessing cerebral perforating arteries on widely accessible 3T systems would be advantageous.
Jianing Tang, Sang Hun Chung, Maria Gamez, Tianrui Zhao, Michael S. Wolf, Dilip K. Pandey, Philip B. Gorelick, Lirong Yan   +7 more
wiley   +1 more source

Longitudinal 4D Flow MRI‐Derived Wall Shear Stress in Patients With an Abdominal Aortic Aneurysm

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background 4D flow MRI‐derived parameters such as wall shear stress (WSS) may improve abdominal aortic aneurysm (AAA) progression prediction. Validation of this biomarker is needed, but longitudinal data are lacking. Purpose Investigate longitudinal WSS changes and associations with AAA morphology. Study Type Prospective.
E. Aalbregt, W. Stehling, E. M. Schrauben, J. van Schuppen, L. J. Meijboom, R. A. P. Takx, A. J. Nederveen, P. van Ooij, V. Jongkind, K. K. Yeung   +9 more
wiley   +1 more source

Shortened outreach periodontal therapy in nursing home residents with periodontitis: A randomized controlled trial

Journal of Periodontology, EarlyView.
Abstract Background We examined the clinical effectiveness of shortened outreach periodontal therapy for 3 months in nursing home residents with periodontitis versus controls (no therapy). Methods Nursing home residents with periodontitis were randomly assigned to either (a) one‐time, shortened outreach periodontal therapy adapted to German statutory ...
Anna G. Barbe, Dalia Beck, Martin Hellmich, Max von Kohout, Sonja H. M. Derman, Dirk Bleiel   +5 more
wiley   +1 more source

Bioactive Properties of Persea americana Peel Extract and Their Role in Hypercholesterolemia Management and Cardiovascular Health

Foods
Cardiovascular diseases remain the leading cause of death worldwide, with hypercholesterolemia being a major contributing risk factor. Although cholesterol-lowering drugs are widely available, concerns about several adverse side effects have increased ...
Laura M. Teixeira, Catarina P. Reis, Rita Pacheco   +2 more
doaj   +1 more source