Results 11 to 20 of about 182,037 (304)

Web-Based Tool (FH Family Share) to Increase Uptake of Cascade Testing for Familial Hypercholesterolemia: Development and Evaluation

JMIR Human Factors, 2022
BackgroundFamilial hypercholesterolemia, a prevalent genetic disorder, remains significantly underdiagnosed in the United States.
Hana Bangash, Ahmed Makkawy, Justin H Gundelach, Alexandra A Miller, Kimberly A Jacobson, Iftikhar J Kullo   +5 more
doaj   +1 more source

Education on Prevention of Hypercholesterolemia and Hypertension by Consuming Sardeljondan Herbal Drinks

Jurnal Soeropati, 2022
Hypertension is a condition in which a person experiences an increase in systolic blood pressure of more or equal to 140 mmHg and diastolic blood pressure of more or equal to 90 mmHg.
Yauwan Tobing Lukiyono, Abraham Ahmad Ali Firdaus, Salfa Salsabilah Zain, Anis Hanifa Rahmawati, Nur Zulviah   +4 more
doaj   +1 more source

Precision screening for familial hypercholesterolaemia: a machine learning study applied to electronic health encounter data

The Lancet: Digital Health, 2019
Summary: Background: Cardiovascular outcomes for people with familial hypercholesterolaemia can be improved with diagnosis and medical management. However, 90% of individuals with familial hypercholesterolaemia remain undiagnosed in the USA. We aimed to
Kelly D Myers, BS, Joshua W Knowles, MD, David Staszak, PhD, Michael D Shapiro, DO, William Howard, PhD, Mrinal Yadava, MD, David Zuzick, MBA, Latoya Williamson, MS, Nigam H Shah, PhD, Juan M Banda, PhD, Joe Leader, BS, William C Cromwell, MD, Ed Trautman, PhD, Michael F Murray, ProfMD, Seth J Baum, MD, Seth Myers, PhD, Samuel S Gidding, MD, Katherine Wilemon, BS, Daniel J Rader, ProfMD   +18 more
doaj   +1 more source

Effectiveness and safety of PCSK9 inhibitor therapy in patients with familial hypercholesterolemia within a therapeutic program in Poland: Preliminary multicenter data

Cardiology Journal, 2022
BACKGROUND: In Poland, treatment with proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors has become available free of charge in a therapeutic program. Assessed herein, is the efficacy and safety of alirocumab and evolocumab in patients with
Krzysztof Chlebus, Barbara Cybulska, Piotr Dobrowolski, Marzena Romanowska-Kocejko, Marta Żarczyńska-Buchowiecka, Natasza Gilis-Malinowska, Aneta Stróżyk, Justyna Borowiec-Wolna, Marcin Pajkowski, Beata Bobrowska, Renata Rajtar-Salwa, Aleksandra Kwapiszewska, Małgorzata Waluś-Miarka, Magdalena Chmara, Rafał Gałąska, Maciej Małecki, Tomasz Zdrojewski, Marcin Gruchała   +17 more
doaj   +1 more source

Liver Transplantation to Provide Low-Density-Lipoprotein Receptors and Lower Plasma Cholesterol in a Child with Homozygous Familial Hypercholesterolemia [PDF]

, 1984
A six-year-old girl with severe hypercholesterolemia and atherosclerosis had two defective genes at the low-density-lipoprotein (LDL) receptor locus, as determined by biochemical studies of cultured fibroblasts.
Cummings, David W. Bilheimer, Goldstein, Joseph L. Goldstein, Michael S. Brown, Pittman, Schneider, Schneider, Scott M. Grundy, Thomas E. Starzl   +9 more
core   +1 more source

Young women with familial hypercholesterolemia have higher LDL-cholesterol burden than men: Novel data using repeated measurements during 12-years follow-up

Atherosclerosis Plus, 2023
Background and aims: The concentration and the duration of exposure to low-density lipoprotein cholesterol (LDL-C) (LDL-C burden) is an important determinant of risk for cardiovascular disease and thresholds has recently been estimated.
Anja K. Johansen, Martin P. Bogsrud, Jacob J. Christensen, Amanda Rundblad, Ingunn Narverud, Stine Ulven, Gisle Langslet, Kjetil Retterstøl, Kirsten B. Holven   +8 more
doaj   +1 more source

Metabolism of low-density lipoproteins by cultured hepatocytes from normal and homozygous familial hypercholesterolemic subjects [PDF]

, 1986
The profoundly elevated concentrations of low-density lipoproteins (LDL) present in homozygous familial hypercholesterolemia lead to symptomatic cardiovascular disease and death by early adulthood.
Brewer, HB, Demosky, SJ, Edge, SB, Gregg, RE, Hoeg, JM, Starzl, TE, Triche, T   +6 more
core   +1 more source

Genetics of Hypercholesterolemia: Comparison Between Familial Hypercholesterolemia and Hypercholesterolemia Nonrelated to LDL Receptor

Frontiers in Genetics, 2020
Severe hypercholesterolemia (HC) is defined as an elevation of total cholesterol (TC) due to the increase in LDL cholesterol (LDL-C) >95th percentile or 190 mg/dl.
Estíbaliz Jarauta, Estíbaliz Jarauta, Estíbaliz Jarauta, Ana Ma Bea-Sanz, Ana Ma Bea-Sanz, Victoria Marco-Benedi, Victoria Marco-Benedi, Itziar Lamiquiz-Moneo, Itziar Lamiquiz-Moneo, Itziar Lamiquiz-Moneo   +9 more
doaj   +1 more source

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals. [PDF]

, 2018
Large-scale deep-coverage whole-genome sequencing (WGS) is now feasible and offers potential advantages for locus discovery. We perform WGS in 16,324 participants from four ancestries at mean depth >29X and analyze genotypes with four quantitative ...
Abecasis, Goncalo, Alver, Maris, Bloom, Jonathan M, Chaffin, Mark, Correa, Adolfo, Cupples, L Adrienne, Engreitz, Jesse M, Ernst, Jason, Esko, Tonu, Ganna, Andrea, Johnson, W Craig, Kathiresan, Sekar, Kellis, Manolis, Khera, Amit V, Lander, Eric S, Manichaikul, Ani, Mitchell, Braxton, Montasser, May, Natarajan, Pradeep, Neale, Benjamin M, NHLBI TOPMed Lipids Working Group, O'Connell, Jeffrey R, Peloso, Gina M, Perry, James A, Poterba, Timothy, Rich, Stephen S, Ripatti, Samuli, Rotter, Jerome I, Ruotsalainen, Sanni E, Salomaa, Veikko, Seed, Cotton, Surakka, Ida L, Vasan, Ramachandran S, Willer, Cristen J, Wilson, James G, Zekavat, Seyedeh Maryam, Zhou, Wei   +36 more
core   +2 more sources

The effects of cholesterol accumulation on Achilles tendon biomechanics: A cross-sectional study.

PLoS ONE, 2021
Familial hypercholesterolemia, a common genetic metabolic disorder characterized by high cholesterol levels, is involved in the development of atherosclerosis and other preventable diseases.
Kipling Squier, Alexander Scott, Michael A Hunt, Liam R Brunham, David R Wilson, Hazel Screen, Charlie M Waugh   +6 more
doaj   +1 more source