Results 41 to 50 of about 120,195 (312)

The Effect of Hypercholesterolemia on Cortical Bone Thickness of Wistar Rats (Rattus norvegicus)

Folia Medica Indonesiana, 2021
There have been several studies reporting the effect of hypercholesterolemia on cortical thickness, but it remains a controversy. Some studies suggest that hypercholesterolemia can decrease osteoblast activity and increase osteoclast activity.
Auliya Dzaqiyatus Sofka, Pudji Lestari, Gadis Meinar Sari   +2 more
doaj   +1 more source

LDLR-Gene therapy for familial hypercholesterolaemia: Problems, progress, and perspectives [PDF]

, 2010
Coronary artery diseases (CAD) inflict a heavy economical and social burden on most populations and contribute significantly to their morbidity and mortality rates.
Charles Coutelle, Harbottle, R, Anna L David, Themis, M, Al-Allaf, FA, Waddington, SN, David, A, Faisal A Al-Allaf, Michael Themis, Coutelle, C, Simon N Waddington, Richard Harbottle   +11 more
core   +1 more source

Genetic Risk and High Burden of Depression and Suicide in the Maya‐Mestizo Population of Yucatán, México

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Major depression and suicide are critical public health concerns, particularly in underrepresented populations with unique genetic and sociocultural contexts. The Maya‐mestizo population presents the highest suicide rates in the country but remains understudied in psychiatric genetics. This study evaluated the association between three genetic
Marta Menjivar, Erandi Bravo, Margarita Rivera‐Balancan, Barbara Itzel Pena Espinoza   +3 more
wiley   +1 more source

Renal Expression of Monocyte Chemoattractant Protein-1 in Low-Density Lipoprotein Receptor Knockout Mice with Diet-Induced Hypercholesterolemia [PDF]

, 1999
Abnormalities in lipid metabolism appear to play a pivotal role in progressive renal diseases.Monocyte chemoattractant protein (MCP)-1 plays pivotal roles in several inflammatory conditions including renal damage in diabetes.However,the pathogenesis of ...
林, 晋一郎, 磯部, 光章, 鈴木, 淳一, 加藤, 真帆人   +3 more
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Immune Modulatory Effects of Hypercholesterolemia: Can Atorvastatin Convert the Detrimental Effect of Hypercholesterolemia on the Immune System?

Iranian Journal of Allergy, Asthma and Immunology, 2019
Many observations showed that hypercholesterolemia can disrupt immune response. Statin drugs that were used for the treatment of hypercholesterolemia patients can interfere in the regulation of the immune response and cytokine secretion.
Zeinab Emruzi, Pegah Babaheidarian, Mahmoud Arshad, Hannes Stockinger, Ghasem Ahangari   +4 more
doaj   +1 more source

Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco, Alfonso Manuel D'Alessio, Nicola Brunetti‐Pierri   +2 more
wiley   +1 more source

Pitavastatin approved for treatment of primary hypercholesterolemia and combined dyslipidemia [PDF]

, 2010
Jun SasakiPharmaceutical Medicine, International University of Health and Welfare Graduate School, Fukuoka, JapanAbstract: Pitavastatin was first developed in Japan and is expanding the regions in which it is clinically available.
Jun Sasaki
core   +1 more source

Cholesterol contributes to dopamine-neuronal loss in MPTP mouse model of Parkinson's disease: Involvement of mitochondrial dysfunctions and oxidative stress.

PLoS ONE, 2017
Hypercholesterolemia is a known contributor to the pathogenesis of Alzheimer's disease while its role in the occurrence of Parkinson's disease (PD) is only conjecture and far from conclusive.
Rajib Paul, Amarendranath Choudhury, Sanjeev Kumar, Anirudha Giri, Rajat Sandhir, Anupom Borah   +5 more
doaj   +1 more source

Diabetes and the Metabolic Syndrome as Drivers of Neurodegeneration: Convergent Mechanisms Linking Peripheral Neuropathy and Dementia

Annals of Neurology, EarlyView.
The metabolic syndrome, a state of progressive metabolic dysfunction, injures the peripheral and central nervous systems, promoting peripheral neuropathy (PN) and cognitive impairment (CI), respectively. We posit PN and CI are connected in the metabolic syndrome framework, built on the premise that neurons, whether in the peripheral or central nervous ...
Masha G. Savelieff, David L. Bennett, Troels S. Jensen, Eva L. Feldman   +3 more
wiley   +1 more source

Treatment of Familial Hypercholesterolemia [PDF]

, 2018
Familial hypercholesterolemia is the most prevalent genetic disorder with a autosomal dominant background. Early detection of the condition is important, diagnosing the disease is easily missed in most of the cases until some abnormally early CVD ...
Alharshani, Bushra Farhan M
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