Results 51 to 60 of about 132,170 (308)

A Rare Form of Microcephalic Primordial Dwarfism due to NSMCE2 Deficiency (Seckel Syndrome Type 10): A Report of Macular Involvement

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic variants in NSMCE2 (MMS21), which encodes the SUMO E3 ligase subunit of the SMC5/6 chromatin‐maintenance complex, have recently been implicated in microcephalic primordial dwarfism (MPD), corresponding to Seckel syndrome type 10 (OMIM #617246).
Cristina Peduto, Céline Huber, Clément Paya, Isabelle Audo, Nathalie Boddaert, Valérie Cormier‐Daire   +5 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Immune Modulatory Effects of Hypercholesterolemia: Can Atorvastatin Convert the Detrimental Effect of Hypercholesterolemia on the Immune System?

Iranian Journal of Allergy, Asthma and Immunology, 2019
Many observations showed that hypercholesterolemia can disrupt immune response. Statin drugs that were used for the treatment of hypercholesterolemia patients can interfere in the regulation of the immune response and cytokine secretion.
Zeinab Emruzi, Pegah Babaheidarian, Mahmoud Arshad, Hannes Stockinger, Ghasem Ahangari   +4 more
doaj   +1 more source

Characteristics of participants with hypercholesterolemia: frequencies and odds ratios for receipt of treatment for hypercholesterolemia in older adults.

, 2015
Characteristics of participants with hypercholesterolemia: frequencies and odds ratios for receipt of treatment for hypercholesterolemia in older adults.
Jingjing Wang (140791), Janet L. Peacock (768028), Ruoling Chen (114951), M. Justin Zaman (768027), Zhi Hu (114954)   +4 more
core   +1 more source

Mechanical Thrombectomy Versus Medical Management for Large Ischemic Core Stroke Identified before Inter‐Hospital Transfer: A Post Hoc Analysis of the LASTE Trial

Annals of Neurology, EarlyView.
Objective This study assessed the efficacy of thrombectomy in acute ischemic stroke because of large‐vessel occlusion (AIS‐LVO) initially admitted to primary stroke centers (PSC) and subsequently transferred to a comprehensive stroke center (CSC), with a large ischemic core identified before transfer.
Pierre Seners, Adrien ter Schiphorst, Julien Labreuche, Bertrand Lapergue, Hilde Henon, Nasreddine Nouri, Benjamin Gory, Sébastien Richard, Jean‐François Albucher, Christophe Cognard, Liesjet E.H. van Dokkum, David S. Liebeskind, Tudor G. Jovin, Vincent Costalat, Caroline Arquizan, for the LASTE investigators, Caroline Arquizan, Vincent Costalat, Xavier Ayrignac, Mahmoud Charif, Lucas Corti, Cyril Dargazanli, Imad Derraz, Nicolas Gaillard, Grégory Gascou, Pierre‐Henri Lefevre, Anaïs Lippi, Isabelle Mourand, Pauline Prin, Perrine Schmitt, Florian Savenier, Adrien Ter Schiphorst, Igor Sibon, Gaultier Marnat, Pierre Briau, Florent Gariel, Jean‐Sébastien Liegey, Malgorzata Milnerowicz, Jean Papaxanthos, Lisa Papillon, Sophie Godard, Anne Pasco‐Papon, Alice Corfu, Jean‐Baptiste Girot, Vincent L'Allinec, Alderic Lecluse, Matthias Lamy, Stéphane Velasco, Nadeem Beydoun, Samy Boucebci, Victor Dumas, Cédric Fauche, Jean‐Philippe Neau, Paola Palazzo, Nicolas Raynaud, Emmanuel Houdart, Mikael Mazighi, Agnès Aghetti, Anna Dimitrovic, Alexis Guedon, Peggy Reiner, Olivier Naggara, Guillaume Turc, Wagih Benhassen, Basile Kerleroux, Christine Rodriguez Regent, Frédéric Clarencon, Sonia Alamowitch, Julien Allard, Flore Baronnet, Sophie Crozier, Stephen Delorme, Sandrine Deltour, Gaspard Gerschenfeld, Anne leger, Kevin Premat, Charlotte Rosso, Yves Samson, Eimad Shotar, Laurent Spelle, Christian Denier, Jildaaz Caroff, Vanessa Chalumeau, Olivier Chassin, Sophie Gallas, Léon Ikka, Nicolas Legris, Mariana Sarov Riviere, Laura Venditti, Benjamin Gory, Sébastien Richard, René Anxionnat, Mathieu Bonnerot, Liang Liao, Nolwenn Riou‐Comte, Romain Bourcier, Benoît Guillon, Pierre‐Louis Alexandre, Benjamin Daumas‐Duport, Hubert Desal, Lili Detraz, Cécile Preterre, Valérie Wolff, Raoul Pop, Yannick Bejot, Frédéric Ricolfi, Laura Baptiste, Pierre‐Olivier Comby, Brivael Lemogne, Pierre Thouant, Jean‐Christophe Gentric, Serge Timsit, François‐Mathias Merrien, Lorena Nico, Julien Ognard, Laurina Simoni, Chrysanthi Papagiannaki, Ozlem Ozkul, Aude Triquenot Bagan, Michel Piotin, Michael Obadia, Pierre Seners, Nasreddine Nouri, Hilde Henon, Marie Bodenant, Nicolas Bricout, Barbara Casolla, Nelly Dequatre, Lucie Della Shiava, Maco Pasi, François Caparros, Laurent Puy, Arnaud Karam, Olfa Kaaouana, Kaelig Watel, Giuseppe Scopelliti, Mariam Annan, Grégoire Boulouis, Richard Bibi, Arnaud Bretonniere, Marie Gaudron, Denis Herbreteau, Héloise Ifergan, Kevin Jannot, Elisabeth Molinier, Maco Pasi, Cyril Chivot, Chantal Lamy, Emmanuel Wiener, Audrey Arnoux Courselle, Sandrine Canaple, Elisa Ouin, Charbel Mounayer, Francisco Macian Montoro, Suzana Saleme, Omer Eker, Tae‐Hee Cho, Morgane Laubacher, Roberto Riva, Christophe Cognard, Jean‐François Albucher, Lionel Calviere, Louis Fontaine, Jean‐Marc Olivot, Nicolas Raposo, Alain Viguier, Laurent Suissa, Hervé Brunel, Emilie Doche, Nadia Laksiri, Stephanie Machado, Ophelie Osman, Roxane Peres, Emanuelle Robinet, Caroline Rey, Federico Di Maria, Bertrand Lapergue, Emmanuel Chabert, Anna Ferrier, Elie Lteif, Pere Cardona, Lara Blanca, Helena Quesada, Ana Núñez, Andrés Paipa, Mònica Millán, Alejandro Bustamante, Laura Dorado Bouix, Christopher Calib, Jaime Carbonell, Gema Eugenia García Amor, Garbiñe Ezcurra, Belén Flores, Manuel Gómez Choco, Meritxell Gomis Cortina, María Hernández Pérez, Marina Hernández, Clara Larrañaga, Manuel Domínguez Lizarbe, Marina Martínez, Alex Menéndez Albarracín, Natalia Pérez de la Ossa, Neus Rabaneda, Anna Ramos Pachón, Luis Alejandro Rodríguez, Sara Rubio, Isabel Puig, Daniel Santana l, Adrian Valls, Barbara Yugueros, Denisse Wenger, Arturo Renú, Sergio Amaro, Mircea Balasa, Jose Maria Cabrera, Ángel Chamorro, Estefania Conde, Jose Miguel Contador, Antonio Doncel‐Mariano, Mar Guasp, Laura Llansó, Laura Llull, Gerard Mayà Casalprim, Carmen Montejo, Alejandro Rodríguez, Salvatore Rudilosso, Almudena Sánchez, Daniel Santana, Xabier Urra Nuin, Víctor Augusto Vera Monge, Juan F. Arenillas, Mercedes De Lera, María Esther Ramos, María del Mar Freijo, Garazi Aguirre, Laura Cabral, Irene Díaz, Alejandro Durán Lozano, Alain Luna, Jon Martín, Ana Moreno Estébanez, Walter Sifontes, Iratxe Ugarriza, Elena López‐Cancio, Pedro Vega, Lorena Benavente, Sergio Calleja Puerta, María Castañón Apilánez, Álvaro Criado, David Fuentes, Carmen García‐Cabo, Montserrat González Delgado, Gemma María González, Javier Molina Gil, Davinia Larrosa Campo, Begoña López López, Antía Reguera Acuña, María Rico Santos, Patricia Zunzunegui   +258 more
wiley   +1 more source

Ocular manifestations of severe familial hypercholesterolemia

Heliyon
Background: To study ocular manifestations of patients with severe familial hypercholesterolemia (FH). Methods: In this population-based case-control study, patients suffering from severe familial hypercholesterolemia from the Lebanese Familial ...
Alaa Bou Ghannam, Rachid Istambouli, Mohamed S. Hamam, Jean M. Chalhoub, Akl C. Fahed, Rola N. Hamam   +5 more
doaj   +1 more source

Cholesterol contributes to dopamine-neuronal loss in MPTP mouse model of Parkinson's disease: Involvement of mitochondrial dysfunctions and oxidative stress.

PLoS ONE, 2017
Hypercholesterolemia is a known contributor to the pathogenesis of Alzheimer's disease while its role in the occurrence of Parkinson's disease (PD) is only conjecture and far from conclusive.
Rajib Paul, Amarendranath Choudhury, Sanjeev Kumar, Anirudha Giri, Rajat Sandhir, Anupom Borah   +5 more
doaj   +1 more source

Quality of Dabai Pulp Oil Extracted by Supercritical Carbon Dioxide and Supplementation in Hypercholesterolemic Rat—A New Alternative Fat

Foods, 2021
Dabai pulp oil (DPO) is new oil extracted from the pulp of Canarium odontophyllum. The quality and efficacy of DPO are needed to promote its potential as a new alternative fat.
Noor Atiqah Aizan Abdul Kadir, Azrina Azlan, Faridah Abas, Intan Safinar Ismail   +3 more
doaj   +1 more source

Cerebrospinal Fluid Cytokine Expression and Relationships With Neurological Measures in Virologically Controlled People With HIV

Annals of Neurology, EarlyView.
Objective Quantify cytokines in cerebrospinal fluid (CSF) of virologically suppressed people with HIV (PWH) and people without HIV (PWoH) and correlate these with neuroimaging, neuropsychometric (NP), and neurodegenerative measurements. Methods CSF samples were collected from virologically suppressed PWH and demographically matched PWoH under a natural
Jack Peterson, Clarissa Xia, Govind Nair, Joseph Snow, Julia Stone, Gina Norato, Brandon Do, Samuel Darko, Kory Johnson, Swati Shah, Amanda Wiebold, Melina Jones, Avindra Nath, Darshan Pandya   +13 more
wiley   +1 more source

Relationship Of Waist Circumference And Hypercholesterolemia Incidence In Patient With Hypertension in Tegal Gundil Public Health Center at Bogor City

Jurnal Kesehatan Komunitas (Journal of Community Health), 2019
Hypertension and hypercholesterolemia are the causes of coronary heart disease (CHD) so that the presence of hypercholesterolemia in patients with hypertension will increase the risk of CHD.
Siti Hana, Ratu Ayu Dewi Sartika
doaj   +1 more source