Results 51 to 60 of about 180,738 (304)

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Relationship Of Waist Circumference And Hypercholesterolemia Incidence In Patient With Hypertension in Tegal Gundil Public Health Center at Bogor City

Jurnal Kesehatan Komunitas (Journal of Community Health), 2019
Hypertension and hypercholesterolemia are the causes of coronary heart disease (CHD) so that the presence of hypercholesterolemia in patients with hypertension will increase the risk of CHD.
Siti Hana, Ratu Ayu Dewi Sartika
doaj   +1 more source

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco, Alfonso Manuel D'Alessio, Nicola Brunetti‐Pierri   +2 more
wiley   +1 more source

Threat of Hypercholesterolemia in Urban Adults and Its Associates: Evidence from a Community-Based Study

Makara Journal of Health Research
Background: Hypercholesterolemia is an abnormality of lipids. It is a crucial modifiable risk factor for cardiovascular diseases. There is a paucity of community-based studies on hypercholesterolemia in the adult population in India.
Ambika Rani Yadav, Priya Keshari
doaj   +1 more source

COMPARATIVE STUDY OF HYPOCHOLESTEROLEMIC EFFECT ON TAURINE ANDSIMVASTATIN IN MALE RATS [PDF]

Basrah Journal of Veterinary Research, 2016
This study was conducted to investigate the effect of Taurine as hypocholesterolemic agentand compare with the results of simvastatin drug on male rats. The experiment consisted of 36adult male rats (Rattus norvegicus) weighting range 170 -200 gm divided
Hanadi Al_hilfi, Ahlam Al-Rekabi, Wasfi Al- Masoudi, kamal alsaad, Abdulkadhim Aneed, Karima Al-Salihi, Ali Ajeel, Kasim Hussein Ali, Iman AlShati, Najlaa Ibrahim, Nadhim Jakhsi, Gahin Taib, Mahdi Abdullah, Rizgar Nabi, Nameer A.Kareem Al zubaidi, Mortadha Salh Hatim   +15 more
doaj   +1 more source

Alterations of intestinal lipoprotein metabolism in diabetes mellitus and metabolic syndrome [PDF]

, 2015
Diabetes and metabolic syndrome are associated with abnormal postprandial lipoprotein metabolism, with a significant delay in the clearance of many lipid parameters, including triglycerides and chylomicrons.
ARCA, Marcello
core   +1 more source

Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Have Distinct Prediagnostic Blood Biochemical Profiles

Annals of Neurology, EarlyView.
Objective Identifying modifiable factors influencing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) risk is important for prevention. Blood biomarkers, particularly cholesterol, have been associated with neurodegenerative risk, but findings in ALS are inconsistent, and data on FTD are limited.
Christos V. Chalitsios, Jiali Gao, Carol A.C. Coupland, Julia Hippisley Cox, Martin R. Turner, Alexander G. Thompson   +5 more
wiley   +1 more source

THE EFFECT OF GALLIC ACID AS PROTECTIVE AGENT ON SOME BIOCHEMICAL PARAMETERS INDUCED HYPERCHOLESTEROLEMIA IN LABORATORY MALE RATS [PDF]

Basrah Journal of Veterinary Research, 2017
The role of gallic acid was studied to alleviating some biochemical parameters alterations in hyper cholesterolemia in rats. For this purpose 24 sexually adult male rats were divided randomly in to 4 groups (6 rats each).
Muna F. Abass AL-Taei, Mohammad A. AL-Diwan   +1 more
doaj   +1 more source

HYPERCHOLESTEROLEMIA;

The Professional Medical Journal, 2014
Objective: To compare the efficacy of Simvastatin with Atorvastatin in loweringLow Density Lipoprotein Cholesterol (LDL-C) in patients with Hypercholesterolemia in a tertiarycare hospital. Design: Prospective, observational, single center study. Setting: Department ofMedicine, Khyber Teaching Hospital, Peshawar.
Zahidullah Khan, Inamullah Khan, Fazle Subhan   +2 more
openaire   +2 more sources