Results 11 to 20 of about 30,982 (276)

Developing Topics. [PDF]

Alzheimers Dement
Abstract Background Alzheimer’s disease (AD) models play a critical role in understanding the cognitive impairments associated with β‐amyloid and/or tau accumulation. Additionally, sex differences in tau pathology have been linked to disparities in disease progression in clinical settings, which may limit the translational relevance of current models ...
Prauchner GRK, Junior OVR, de Souza Wyse AT.   +2 more
europepmc   +4 more sources

Effect of hyperhomocysteinemia on a murine model of smoke-induced pulmonary emphysema

Scientific Reports, 2022
Hyperhomocysteinemia was reported to enhance endoplasmic reticulum (ER) stress and subsequent apoptosis in several cells. However, the precise mechanisms of smoking susceptibility associated with hyperhomocysteinemia has not been fully elucidated.
Hiroshi Nakano, Sumito Inoue, Yukihiro Minegishi, Akira Igarashi, Yoshikane Tokairin, Keiko Yamauchi, Tomomi Kimura, Michiko Nishiwaki, Takako Nemoto, Yoichiro Otaki, Masamichi Sato, Kento Sato, Hiroyoshi Machida, Sujeong Yang, Hiroaki Murano, Masafumi Watanabe, Yoko Shibata   +16 more
doaj   +1 more source

Thrombophilia in hyperhomocysteinemia [PDF]

International Journal of Emergency Medicine, 2010
A 23-year-old otherwise healthy male presented with development of painful blackish discoloration of the right thumb and index finger and of the right big toe and area over the ankle (Figs. 1 and ​and2),2), as well as painful swelling of both lower limbs, especially on the right side (Fig. 3). Homans′sign was present bilaterally.
Sharma, Vishal, Agarwal, Mukul P., Giri, Subhash, Sahu, Srimanta K., Roy, Ujjawal   +4 more
openaire   +2 more sources

Protective vascular and cardiac effects of inducible nitric oxide synthase in mice with hyperhomocysteinemia. [PDF]

PLoS ONE, 2014
Diet-induced hyperhomocysteinemia produces endothelial and cardiac dysfunction and promotes thrombosis through a mechanism proposed to involve oxidative stress.
Sanjana Dayal, Ilya O Blokhin, Rochelle A Erger, Melissa Jensen, Erland Arning, Jeff W Stevens, Teodoro Bottiglieri, Frank M Faraci, Steven R Lentz   +8 more
doaj   +1 more source

Deficiency of superoxide dismutase promotes cerebral vascular hypertrophy and vascular dysfunction in hyperhomocysteinemia. [PDF]

PLoS ONE, 2017
There is an emerging consensus that hyperhomocysteinemia is an independent risk factor for cerebral vascular disease and that homocysteine-lowering therapy protects from ischemic stroke.
Sanjana Dayal, Gary L Baumbach, Erland Arning, Teodoro Bottiglieri, Frank M Faraci, Steven R Lentz   +5 more
doaj   +1 more source

Case report: Young-onset large vessel ischemic stroke due to hyperhomocysteinemia associated with the C677T polymorphism on 5,10-methylenetetrahydrofolate reductase and multi-vitamin deficiency

Frontiers in Neurology, 2023
Hyperhomocysteinemia is an important risk factor for cerebral infarction. Herein, we report on a 30-year-old man previously diagnosed with epilepsy who presented with right hemiplegia and total aphasia. Magnetic resonance imaging showed a fronto-temporal
Jiro Fukae, Hiroto Eguchi, Yoichi Wada, Atsuhito Fuse, Rika Chishima, Mitsuyoshi Nakatani, Asuka Nakajima, Asuka Nakajima, Nobutaka Hattori, Yasushi Shimo, Yasushi Shimo   +10 more
doaj   +1 more source

Evaluation of platelet distribution width in hypertension with hyperhomocysteinemia

Clinical and Experimental Hypertension, 2020
An increased platelet distribution width (PDW) value has been found in various cardiovascular diseases. The objective of this study was to evaluate the association between the PDW and hypertension with hyperhomocysteinemia in an elderly cohort.
Gang Li, Yanyan Zhang, Zhongwei Zhu, Juan Du   +3 more
doaj   +1 more source

Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats. [PDF]

, 2016
BackgroundHyperhomocysteinemia (HHcy) is associated with inflammation and a rise in the expression of matrix metalloproteinase-9 (MMP-9) in the vascular wall.
Hashimoto, Tomoki, Kanematsu, Yasuhisa, Kitazato, Keiko T, Korai, Masaaki, Matsushita, Nobuhisa, Miyamoto, Takeshi, Nagahiro, Shinji, Satomi, Junichiro, Shimada, Kenji, Tada, Yoshiteru   +9 more
core   +2 more sources

Homocysteine in cerebrovascular disease: An independent risk factor for subcortical vascular encephalopathy [PDF]

, 2001
Hyperhomocysteinemia is a risk factor for obstructive large-vessel disease. Here, we studied plasma concentrations of homocysteine and vitamins in patients suffering from subcortical vascular encephalopathy (SVE), a cerebral small-vessel disease leading ...
Aufenanger, Johannes, Bertsch, Thomas, Casarin, Wendy, Fassbender, Klaus, Höly, Sabine, Kuehl, Sandra, Mielke, Orell, Muehlhauser, Frank, Ragoschke, Andreas, Walter, Silke, Zimmer, Wilma   +10 more
core   +1 more source

Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease, especially in non-insulin-dependent diabetes mellitus - A population-based [PDF]

, 1998
A high serum total homocysteine (tHcy) level is an independent risk factor for cardiovascular disease. Because it is not known whether the strength of the association between hyperhomocysteinemia and cardiovascular disease is similar for peripheral ...
Beks, P.J., Bouter, L.M., Heine, R.J., Hoogeveen, E.K., Jakobs, C., Kostense, P.J., Mackaay, A.J.C., Stehouwer, C.D.A.   +7 more
core   +7 more sources