Results 11 to 20 of about 26,695 (224)
Inhibiting MARSs reduces hyperhomocysteinemia‐associated neural tube and congenital heart defects
EMBO Molecular Medicine, 2020 Hyperhomocysteinemia is a common metabolic disorder that imposes major adverse health consequences. Reducing homocysteine levels, however, is not always effective against hyperhomocysteinemia‐associated pathologies.
Xinyu Mei +21 more
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Parkinson’s Disease Risk and Hyperhomocysteinemia: The Possible Link [PDF]
Cellular and molecular neurobiology, 2023 Parkinson’s disease (PD) is one of the most common degenerative brain disorders caused by the loss of dopaminergic neurons in the substantia nigra (SN). Lewy bodies and -synuclein accumulation in the SN are hallmarks of the neuropathology of PD.
Hayder M. Al‐kuraishy +6 more
openalex +2 more sources
Frontiers in Endocrinology, 2018 As the first time worldwide, this study aimed to investigate the relationships of hyperhomocysteinemia and hyperuricemia with metabolic syndrome (MetS) and renal function in Chinese centenarians. The China Hainan Centenarian Cohort Study was performed in
Shihui Fu +5 more
doaj +2 more sources
Clinical and Experimental Hypertension, 2018 Hyperhomocysteinemia is an independent risk factor for cardiovascular impairment in hypertension. Oxidative stress is important in the molecular mechanisms associated with hypertension, but there are few studies focusing on the comparison of oxidative ...
Gang Guo +4 more
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Hyperhomocysteinemia-Induced Gene Expression Changes in the Cell Types of the Brain
ASN Neuro, 2017 High plasma levels of homocysteine, termed hyperhomocysteinemia, are a risk factor for vascular cognitive impairment and dementia, which is the second leading cause of dementia. While hyperhomocysteinemia induces microhemorrhages and cognitive decline in
Erica M. Weekman +3 more
doaj +2 more sources
Hyperhomocysteinemia in Adult Patients: A Treatable Metabolic Condition
Nutrients, 2023 Hyperhomocysteinemia (HHcy) is recognized as an independent risk factor for various significant medical conditions, yet controversy persists around its assessment and management.
D. González-Lamuño +6 more
semanticscholar +1 more source
BMC Nephrology, 2023 Background Increasing evidence shows that an elevated homocysteine(Hcy) level is associated with an increased risk of chronic kidney disease (CKD). This study systematically evaluated the correlation between homocysteine level and the incidence of CKD ...
Wei Chen +5 more
semanticscholar +1 more source
Involvements of Hyperhomocysteinemia in Neurological Disorders
Metabolites, 2021 Homocysteine (HCY), a physiological amino acid formed when proteins break down, leads to a pathological condition called hyperhomocysteinemia (HHCY), when it is over a definite limit.
M. Cordaro +5 more
semanticscholar +1 more source
Prevalence of Hyperhomocysteinemia in China: An Updated Meta-Analysis
Biology, 2021 Simple Summary Hyperhomocysteinemia has been defined as an elevated serum concentration of homocysteine exceeding 15 μmol/L and has been proven to play an important role in the pathogenesis of cerebrovascular disease.
Yuan Zeng +8 more
semanticscholar +1 more source
Frontiers in Neurology, 2023 Hyperhomocysteinemia is an important risk factor for cerebral infarction. Herein, we report on a 30-year-old man previously diagnosed with epilepsy who presented with right hemiplegia and total aphasia. Magnetic resonance imaging showed a fronto-temporal
Jiro Fukae +10 more
doaj +1 more source