Results 71 to 80 of about 30,982 (276)

Loss of MMP9 leads to altered inflammation and ECM interactions in a mouse model of cerebral small vessel disease

open access: yesAlzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background Vascular contributions to cognitive impairment and dementia (VCID) represent a major cause of dementia. Hyperhomocysteinemia (HHcy)‐driven cerebral small vessel disease (cSVD) leads to the degeneration of astrocytic end‐feet and an upregulation of matrix metalloproteinases (MMPs), which remodel the basement membrane, triggering ...
Joshua Lykins   +6 more
wiley   +1 more source

Comparison of oxidative stress biomarkers in hypertensive patients with or without hyperhomocysteinemia

open access: yesClinical and Experimental Hypertension, 2018
Hyperhomocysteinemia is an independent risk factor for cardiovascular impairment in hypertension. Oxidative stress is important in the molecular mechanisms associated with hypertension, but there are few studies focusing on the comparison of oxidative ...
Gang Guo   +4 more
doaj   +1 more source

Hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in atrophic glossitis patients with macrocytosis

open access: yesJournal of the Formosan Medical Association, 2019
Background/Purpose: Macrocytosis is defined as having the mean corpuscular volume (MCV) ≧ 100 fL. This study evaluated whether 41 atrophic glossitis (AG) patients with macrocytosis had significantly higher frequencies of anemia, hematinic deficiencies ...
Chun-Pin Chiang   +5 more
doaj   +1 more source

Pterostilbene Ameliorates Hyperhomocysteinemia‐Induced Cognitive Impairment: Involvement of Mitochondrial Dysfunction, Synaptic Plasticity, and Adult Neurogenesis

open access: yesAlzheimer's &Dementia, Volume 21, Issue S5, December 2025.
Abstract Background Homocysteine (Hcy) is a sulfur‐containing amino acid generated during protein catabolism, and elevated levels of Hcy, known as hyperhomocysteinemia (HHcy), have been implicated in various neurological disorders. Disruptions in Hcy metabolism, along with deficiencies in folate and vitamin B12, can lead to altered methylation and ...
Bhaskar Jyoti Dutta
wiley   +1 more source

The metabolic syndrome is not associated with homocysteinemia: The Persian Gulf Healthy Heart Study [PDF]

open access: yes, 2009
Background: It is uncertain whether homocysteine and the metabolic syndrome or its components are related in the general population, as studies investigating the association between homocysteine levels and insulin resistance have shown conflicting ...
Nabipour, I   +8 more
core   +4 more sources

An uncommon presentation of hyperhomocysteinemia and vitamin B12 deficiency: a case report

open access: yesJournal of Medical Case Reports, 2019
Introduction Cerebral venous thrombosis is relatively rare and characterized by a wide spectrum of clinical features. It is more common in young adults with women affected more than men.
Vinay Kapur   +2 more
doaj   +1 more source

Deficiencies of the microelements, folate and vitamin B12 in women of the child bearing ages in Gorgan, Northern Iran [PDF]

open access: yes, 2013
Background: The deficiencies of folic acid, vitamin B12, and microelements during pregnancy may affect the health of newborns. Objectives: To assess the serum levels of folate, vitamin B12, iron, zinc and copper in healthy women of the childbearing ages ...
Behnampour, N.   +2 more
core   +1 more source

Corrective effects of hepatotoxicity by hepatic Dyrk1a gene delivery in mice with intermediate hyperhomocysteinemia

open access: yesMolecular Genetics and Metabolism Reports, 2015
Hyperhomocysteinemia results from hepatic metabolism dysfunction and is characterized by a high plasma homocysteine level, which is also an independent risk factor for cardiovascular disease.
Alizée Latour   +9 more
doaj   +1 more source

Study of the Functional State of the Left Ventricular Myocardium in Patients with Coronary Artery Disease with Impaired Metabolism of Homocysteine and Vitamin D

open access: yesУкраїнський журнал серцево-судинної хірургії, 2020
To date, it has been established that in the progression of coronary artery disease (CAD) and its complications, an increase in the level of homocysteine and hypovitaminosis D are essential. However, medical publications do not adequately cover the study
O. S. Nikonenko   +4 more
doaj   +1 more source

Homocysteine treatment alters redox capacity of both endothelial and tumor cells [PDF]

open access: yes, 2015
Homocysteine is a non-proteinogenic amino acid playing key roles in two interconnected metabolic pathways, namely, the activated methyl cycle and the linear trans-sulfuration pathway that allows the conversion of methionine to cysteine.
Cárdenas, Casimiro   +5 more
core  

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