Insulin Injections Promote the Growth of Aberrant Crypt Foci in the Colon of Rats [PDF]
, 1997 The main objective of the present study was to test the hypothesis that exogenous insulin would enhance colon carcinogenesis. Thirty-six female F344 rats, fed ad libitum a low fat rodent chow, received a single azoxymethane injection (20 mg/kg), and were
Corpet, Denis E. +3 more
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Risk of Type II Diabetes Mellitus Among B‐Cell Non‐Hodgkin's Lymphoma Survivors
Cancer Medicine, Volume 15, Issue 1, January 2026.ABSTRACT Purpose Advancing therapies have increased B‐cell Non‐Hodgkin's Lymphoma (B‐NHL) patient survival. However, data are limited on the risk of type II diabetes mellitus (type II DM) in adult survivors following treatment. This study examines the risk of type II DM among a Utah population of B‐NHL survivors, compared to the general population ...
Ellenor Chi +9 more
wiley +1 more source
Insulin resistance indicators in aortic disease: A large cohort study
Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.Elevated TyG index and its related parameters were associated with an increased risk of aortic diseases in a prospective cohort of 386 063 participants. Mendelian randomisation suggested a potential causal link with AA but not with aortic dissection (AD). Abstract Background The triglyceride‐glucose index (TyG), a novel marker of insulin resistance, is
Zehua Shao +7 more
wiley +1 more source
The prevalence of hypertension and metabolic clustering (hyperlipidemia and hyperinsulinemia) in healthy older adults [PDF]
, 2000 Chastity N. Lattanzio
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High‐Protein Diet Exacerbates Insulin Resistance via the JNK/IKKβ‐IRS‐1 Pathway
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.A high‐protein diet worsens insulin resistance and β‐cell dysfunction in both normal and T2D mice by increasing hepatic inflammation and suppressing IRS‐1 signalling. Limiting excessive protein intake may help prevent or delay the progression of type 2 diabetes.
Junjun Li +13 more
wiley +1 more source
Association between Hyperinsulinemia and Hypertension among White, Black, and Mexican American Adults. Results from the Third National Health and Nutrition Examination Survey, 1988-1994. [PDF]
, 2001 David W. Brown +4 more
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Serum Uric Acid as a Mediator of Insulin Resistance: Molecular Mechanisms and Metabolic Pathways
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.Elevated SUA can lead to oxidative stress, endothelial dysfunction, inflammation and impaired function of adipocytes—all of which collectively impede insulin receptor activity and downstream signalling. Key pathways involved include activation of the NLRP3 inflammasome, suppression of AMPK and induction of mitochondrial dysfunction.
Nurshad Ali
wiley +1 more source
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.Holothuria leucospilota n‐hexane extract shows antidiabetic, anti‐inflammatory, and anti‐apoptotic effects in STZ‐induced diabetic rats. The extract modulates key pathways in glucose metabolism, insulin secretion, inflammation, and apoptosis. Treatment significantly decreased glucose and amyloid beta levels, increased insulin, and improved glycemic ...
Niloufar Darbandi +1 more
wiley +1 more source
Impact of Obesity on the Growth Hormone Axis: Evidence for a Direct Inhibitory Effect of Hyperinsulinemia on Pituitary Function [PDF]
, 2006 Raúl M. Luque, Rhonda D. Kineman
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Clinical problems caused by obesity [PDF]
, 2010 Over the past few decades the incidence of obesity has doubled worldwide and current estimates classify more than 1.5 billion adults as overweight and at least 500 million of them as clinically obese, with body mass index (BMI) over 25 kg/m2 and 30 kg ...
Kyrou, Ioannis, Weickert, Martin O.
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