Results 221 to 230 of about 82,926 (310)

Uncovering the Metabolic Origins of Polycystic Ovary Syndrome. [PDF]

Cureus
Iyer PJ, Reza H, Chitteti N, Singh A, Goyal R, Saiyad SS, Stephen Raj AER, Singla N, Vats B, Kamaladasan D, Chahal PS, Das A, Reddy P, Lakhani A.   +13 more
europepmc   +1 more source

Growth Hormone Receptor Antagonism Extends Lifespan

Aging Cell, Volume 25, Issue 9, September 2026.
This study provides proof of concept that GH antagonism in GH‐producing mice extends lifespan, supporting further investigation of GH antagonists as potential anti‐aging interventions in animals and humans. ABSTRACT Interventions that disrupt growth hormone (GH) action are recognized as some of the most potent methods for extending lifespan ...
Edward O. List, Darlene E. Berryman, Grace S. Lach, Delaney F. Minto, Keeley Weese, John J. Kopchick   +5 more
wiley   +1 more source

Morning Elevation in Insulin Enhances Afternoon Hepatic Glucose Disposal in Dogs by Increasing Both Insulin Signaling and Glucose Action. [PDF]

Diabetes
Waterman HL, Smith MS, Farmer B, Yankey K, Howard T, Kraft G, Cherrington AD, Edgerton DS.   +7 more
europepmc   +1 more source

Diabetes‐related barriers to cancer screening in women with type 2 diabetes: A qualitative interview study

British Journal of Health Psychology, Volume 31, Issue 3, September 2026.
Abstract Objectives People with type 2 diabetes (T2DM) are more likely to develop breast and bowel cancers. Despite this, cancer screening participation is lower among women with diabetes than among women without diabetes, indicating diabetes‐related barriers to screening, but little research has examined this.
Rebecca Spencer, Georgina Jones, Siobhán McHugh, Ramzi A. Ajjan, Rebecca J. Birch, Laura Ashley   +5 more
wiley   +1 more source

Remodeling the Immune Landscape: How Obesity-Induced SASPs Create a Pro-Tumorigenic Niche. [PDF]

Curr Obes Rep
Abd El-Fattah EE, Ngai G, Mooney R, Aboody KS.   +3 more
europepmc   +1 more source

Subgroups of Adult‐Onset Diabetes: A Prospective Follow‐Up Study of Progression of Insulin Resistance and Deficiency and Association With Liver Steatosis and Fibrosis

Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 8004-8015, September 2026.
ABSTRACT Aims To assess progression of insulin deficiency and resistance in diabetes, the stability of cluster‐based subgrouping, and the association between steatotic liver disease (SLD), liver fibrosis (LF), and tissue insulin resistance. Materials and Methods Participants from a regional diabetes register were studied within 3 years from diagnosis ...
Aleksi Laitinen, Annemari Käräjämäki, Aki J. Käräjämäki, Samu Kurki, Liisa Hakaste, Olof Asplund, Johan Hultman, Kaj Lahti, Mikko Lehtovirta, Emma Ahlqvist, Tiinamaija Tuomi   +10 more
wiley   +1 more source

Insulin Resistance and Cutaneous Squamous Cell Carcinoma: A Narrative Review of Molecular Mechanisms. [PDF]

Iran J Med Sci
Ardinata D, Alferraly TI, Yosi A, Pase MA.   +3 more
europepmc   +1 more source

Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans.

Journal of Clinical Investigation, 1991
E. A. Anderson, R. Hoffman, T. Balon, C. Sinkey, A. Mark   +4 more
semanticscholar   +1 more source

Hyperglycemia during the first 1000 days as a driver of metabolic programming. [PDF]

Front Endocrinol (Lausanne)
Schandl M, Ertl T, Vass RA.
europepmc   +1 more source

Therapeutic Potential of Gene‐Modified MSC‐Exos in Insulin Resistance: Mitochondrial Crosstalk and miRNA Regulation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
ABSTRACT Insulin resistance (IR) is the key driver of type 2 diabetes mellitus, metabolic dysfunction‐associated steatotic liver disease, and cardiometabolic disorders. Mesenchymal stem cell‐derived exosomes (MSC‐Exos) as a potent cell‐free alternative can deliver miRNAs, proteins, and mitochondrial regulators to reactivate the IRS1/PI3K/Akt/GLUT4 axis.
Qinghua Jia, Bing Li, Yuan Xing, Yuanyuan Zhang, Baodong Gao, Xiangying Li, Xiaoqin Ha   +6 more
wiley   +1 more source