Results 101 to 110 of about 10,576 (237)

Defining Acquired Hypothalamic Obesity: An Expert Call for Unified Diagnosis and Therapeutic Action

Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 4437-4441, June 2026.
Hanneke M. van Santen, Ashley H. Shoemaker, Mehul T. Dattani, Christian L. Roth, Mohamad Maghnie, Kevin C. J. Yuen, Christine Poitou, Hermann L. Müller   +7 more
wiley   +1 more source

Prognostic value of triglyceride‐derived metabolic parameters for micro‐ and macrovascular complications and mortality in individuals with type 2 diabetes: The Rio de Janeiro type 2 diabetes cohort study

Diabetic Medicine, Volume 43, Issue 4, April 2026.
Prognostic value of triglyceride‐derived metabolic parameters for micro‐ and macrovascular complications and mortality in individuals with type 2 diabetes. Abstract Aims Triglyceride‐derived metabolic parameters have been proposed as indirect measures of insulin resistance and also as predictors of worse prognosis, mainly in Asian populations. However,
Claudia R. L. Cardoso, Guilherme P. Castro, Nathalie C. Leite, Gil F. Salles   +3 more
wiley   +1 more source

Siblings With Congenital Hyperinsulinism From Possible Parental Gonadal Mosaicism

, 2023
Congenital hyperinsulinism is the most common cause of persistent hypoglycemia in early infancy. Mutations in the gene for heterozygous hepatocyte nuclear transcription factor 4-alpha () account for approximately 5% of cases and are inherited in an ...
Eimicke, Toni, Swartz, Jonathan, Wolschendorf, Robin   +2 more
core  

Surgical Treatment of Congenital Hyperinsulinism: Results from 500 Pancreatectomies in Neonates and Children

Journal of Pediatric Surgery, 2018
Background: Congenital Hyperinsulinism (HI) causes severe hypoglycemia in neonates and children. We reviewed our experience with pancreatectomy for the various types of HI.
N. Adzick, Diva D. De León, Lisa J. States, K. Lord, Tricia R Bhatti, Susan A. Becker, Charles A. Stanley   +6 more
semanticscholar   +1 more source

Association of polymorphism genes LPL, ADRB2, AGT and AGTR1 with risk of hyperinsulinism and insulin resistance in the Kazakh population

Biomedical Reports, 2020
Hyperinsulinism and insulin resistance are closely associated with several common diseases including type 2 of diabetes, cardiovascular diseases, and metabolic syndrome.
A. Shakhanova, N. Aukenov, Alma Nurtazina, M. Massabayeva, D. Babenko, M. Adiyeva, Nurlan Shaimardonov   +6 more
semanticscholar   +1 more source

An OGT Missense Variant With Impaired Enzyme Activity in a Child With Severe Developmental Delay and Hepatoblastoma

American Journal of Medical Genetics Part A, Volume 200, Issue 2, Page 502-510, February 2026.
ABSTRACT O‐GlcNAc transferase (OGT) and its antagonist O‐GlcNAcase (OGA) regulate protein O‐GlcNAcylation, a highly conserved post‐translational modification involved in metabolic sensing. Pathogenic variants in the OGT gene cause an X‐linked congenital disorder of glycosylation (OGT‐CDG) presenting developmental delay, hypotonia, intellectual ...
Alfonso Manuel D'Alessio, Huijie Yuan, Leandro Raul Soria, Sara Basse Hansen, Iolanda Boffa, Paola Arena, Benedetta Attianese, Maureen. O'Sullivan, Noelle Cullinan, Lewis Pang, Daan Marinus Ferdinand van Aalten, Nicola Brunetti‐Pierri, Sally Ann Lynch   +12 more
wiley   +1 more source

Hyperinsulinism-Hypoglycemia-Hyperammonemia Syndrome: A New GLUD1 Mutation

, 2020
The hyperinsulinism hypoglyemia hyperammonemia syndrome (SHI/HA) is the second most common syndrome of congenital hyperinsulinism. The gain of function mutations of the GLUD-1 gene that encodes for the mitochondrial enzyme glutamate dehydrogenase causes ...
Lema, A., Duran, P., Marquez, W. R., Rincon, P. I., Chain, S.   +4 more
core   +1 more source

Prevalence of Adverse Events in Children With Congenital Hyperinsulinism Treated With Diazoxide

Journal of Clinical Endocrinology and Metabolism, 2018
Context Diazoxide, the only U.S. Food and Drug Administration-approved drug to treat hyperinsulinemic hypoglycemia, has been associated with several adverse events, which has raised concerns about the safety of this drug.
A. Herrera, M. Vajravelu, Stephanie Givler, L. Mitteer, C. Avitabile, K. Lord, Diva D. De León   +6 more
semanticscholar   +1 more source

Visual interpretation, not SUV ratios, is the ideal method to interpret 18F-DOPA PET scans to aid in the cure of patients with focal congenital hyperinsulinism.

PLoS ONE, 2020
IntroductionCongenital hyperinsulinism is characterized by abnormal regulation of insulin secretion from the pancreas causing profound hypoketotic hypoglycemia and is the leading cause of persistent hypoglycemia in infants and children.
Pradeep K Garg, Burton Putegnat, Lisa Truong, Courtney Reynolds, Irene Sanchez, Jonathan K Nedrelow, John Uffman, Stephen J Lokitz, Rachid Nazih, Sudha Garg, Paul S Thornton   +10 more
doaj   +1 more source

Hypoglycemia in CDG patients due to PMM2 mutations: Follow up on hyperinsulinemic patients

JIMD Reports, 2020
Background Phosphomannomutase 2 deficiency (PMM2‐CDG) is the most common congenital disorder of glycosylation (CDG). Hypoglycemia has been reported in various CDG including PMM2‐CDG.
Hossein Moravej, Ruqaiah Altassan, Jaak Jaeken, Gregory M. Enns, Carolyn Ellaway, Shanti Balasubramaniam, Pascale De Lonlay, David Coman, Saadet Mercimek‐Andrews, Peter Witters, Eva Morava   +10 more
doaj   +1 more source