Results 81 to 90 of about 10,623 (193)

Visual interpretation, not SUV ratios, is the ideal method to interpret 18F-DOPA PET scans to aid in the cure of patients with focal congenital hyperinsulinism.

PLoS ONE, 2020
IntroductionCongenital hyperinsulinism is characterized by abnormal regulation of insulin secretion from the pancreas causing profound hypoketotic hypoglycemia and is the leading cause of persistent hypoglycemia in infants and children.
Pradeep K Garg, Burton Putegnat, Lisa Truong, Courtney Reynolds, Irene Sanchez, Jonathan K Nedrelow, John Uffman, Stephen J Lokitz, Rachid Nazih, Sudha Garg, Paul S Thornton   +10 more
doaj   +1 more source

Case Report: Food-based enteral formula in the nutritional management of children with hyperinsulinism: single center retrospective case series

Frontiers in Endocrinology
ContextHyperinsulinism is characterized by dysregulated insulin secretion and is typically associated with reduced fasting tolerance. Long-term hyperinsulinism management includes nutrition and medication to normalize plasma glucose levels. Management of
Graeme O’Connor, Lauren Cheng, Annaruby Cunjamalay   +2 more
doaj   +1 more source

Acute Hyperinsulinemia during Hyperinsulinemic-Euglycemic Clamp Influences DNA Methylation and Gene Expression in Peripheral Blood Cells of Adult Men [PDF]

Diabetes & Metabolism Journal
Background Acute hyperinsulinemia may directly affect blood cells. In this study a hyperinsulinemic-euglycemic clamp (HEC) and multiomics methods were used to explore the epigenetic regulation by hyperinsulinemia in blood cells.
Minjae Joo, Dongseong Shin, Xuan Trong Truong, Seungyoon Nam, Dae Ho Lee   +4 more
doaj   +1 more source

Insulin-induced glycosylphosphatidylinositol (GPI) binding to red cell membrane proteins [PDF]

Journal of the Serbian Chemical Society, 2002
In this work GPI binding to membrane proteins from erythrocytes of insulinoma patients for whom prolonged hyperinsulinism and hypoglycemia were characteristic, as well as from normal erythrocytes incubated with supraphysiological concentrations of ...
NENAD TOMASEVIC, VESNA NIKETIC, MILAN NIKOLIC   +2 more
doaj  

Genotype-phenotype association in children with congenital hyperinsulinism

, 2012
Genotype-phenotype association in children with congenital ...
Brusgaard, Klaus, Peterkova, V., Petraykina, E., Christesen, Henrik Thybo, Gurevich, L., Melikyan, M., Averyanova, Y., Volkov, I   +7 more
core   +3 more sources

Defining Acquired Hypothalamic Obesity: An Expert Call for Unified Diagnosis and Therapeutic Action

Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 4437-4441, June 2026.
Hanneke M. van Santen, Ashley H. Shoemaker, Mehul T. Dattani, Christian L. Roth, Mohamad Maghnie, Kevin C. J. Yuen, Christine Poitou, Hermann L. Müller   +7 more
wiley   +1 more source

Hyperinsulinism-Hypoglycemia-Hyperammonemia Syndrome: A New GLUD1 Mutation

, 2020
The hyperinsulinism hypoglyemia hyperammonemia syndrome (SHI/HA) is the second most common syndrome of congenital hyperinsulinism. The gain of function mutations of the GLUD-1 gene that encodes for the mitochondrial enzyme glutamate dehydrogenase causes ...
Lema, A., Duran, P., Marquez, W. R., Rincon, P. I., Chain, S.   +4 more
core   +1 more source

Congenital Hyperinsulinism [electronic resource] : A Practical Guide to Diagnosis and Management /

This unique book is a practical guide for the clinician faced with the challenge of diagnosing and managing neonates, infants and children with congenital hyperinsulinism (HI), within the framework of pathophysiology and molecular genetics.
De León-Crutchlow, Diva D.editor.edthttp://id.loc.gov/vocabulary/relators/edt, Stanley, Charles A.editor.edthttp://id.loc.gov/vocabulary/relators/edt, SpringerLink (Online service)   +2 more
core   +1 more source

Genotype-Phenotype associations in patients with severe hyperinsulinism of infancy

, 2007
In hyperinsulinism of infancy (HI), unregulated insulin secretion causes hypoglycemia. Pancreatectomy may be required in severe cases, most of which result from a defect in the beta-cell K-ATP channel, encoded by ABCC8 and KONJ11.
Greer, Ristan M., Jeske, Jeske, Yvette W., Cowley, David, Brown, David, Jack, Michelle M., Cotterill, Andrew M., Bowling, Francis G., Liaskou, Daphne, Walker, Rosslyn M., Thomsett, Michael J., Harris, Mark, Shah, Janaki, Bell, John R., Choong, Catherine   +13 more
core   +1 more source

Congenital hyperinsulinism

Congenital hyperinsulinism (CHI) is a rare cause of hypoglycemia caused by dysregulated and excessive production of insulin in neonates and infants. CHI is associated with significant morbidity and is responsible for brain injury in many patients.
Shaikh, Mohammed Guftar, Flanagan, Sarah E., Cosgrove, Karen E., Estebanez, Maria Salomon, Craigie, Ross, Worth, Chris, Raskin, Julie, Banerjee, Indraneel   +7 more
core   +1 more source