Results 61 to 70 of about 10,576 (237)
The impact of subtotal pancreatectomy on people with congenital hyperinsulinism and their caregivers
Frontiers in EndocrinologyIntroductionCongenital hyperinsulinism (HI) is a rare disorder characterized by severe, recurrent hypoglycemia. Subtotal pancreatectomy remains a treatment option for diffuse HI, but post-surgery quality of life is largely undescribed.MethodsThis mixed ...
Kristen E. Rohli +8 more
doaj +1 more source
The Genetic and Molecular Mechanisms of Congenital Hyperinsulinism
Frontiers in Endocrinology, 2019 Congenital hyperinsulinism (CHI) is a heterogenous and complex disorder in which the unregulated insulin secretion from pancreatic beta-cells leads to hyperinsulinaemic hypoglycaemia.
S. Galcheva +3 more
semanticscholar +1 more source
Clinical Case Reports, 2020 Advances in genomics and 18F‐DOPA PET‐CT imaging have transformed the management of infants with Congenital Hyperinsulinism. Preoperative diagnosis of focal hyperinsulinism permits limited pancreatectomy with improved clinical outcomes while knowledge of
Caroline M. Joyce +4 more
doaj +1 more source
Laparoscopic Surgery for Focal-Form Congenital Hyperinsulinism Located in Pancreatic Head
Frontiers in Pediatrics, 2022 Background and AimsCongenital hyperinsulinism of infancy (CHI) is a rare condition that may cause irreversible severe neurological damage in infants. For children in whom medical management fails, partial or near-total pancreatectomy is then required ...
Zhe Wen +6 more
doaj +1 more source
Case Report: The importance of genetic counseling for families with hyperinsulinism
Frontiers in PediatricsCongenital hyperinsulinism (HI) is the most common cause of persistent hypoglycemia in infancy. Genotype-phenotype correlations directly inform medical care for patients.
Victoria R. Sanders +18 more
doaj +1 more source
Hormone Research in Paediatrics, 2020 Background: Effective treatment and close monitoring in children with congenital hyperinsulinism (HI) are important to prevent hypoglycemic-associated brain damage.
Arpana Rayannavar +3 more
semanticscholar +1 more source
International Journal of Endocrinology, 2016 Objective. The aim of this study was to assess the utility of arterial calcium stimulation with hepatic venous sampling (ASVS) in the localization diagnosis of endogenous hyperinsulinism. Patients and Methods.
Paloma Moreno-Moreno +6 more
doaj +1 more source
Acta Paediatrica, EarlyView.ABSTRACT Aim Neonates discharged home on medications remain at risk of medication errors. The PADDINGToN programme previously developed parent co‐designed resources to support safer medication administration following discharge. The aim of this study, PADDINGToN‐2, is to evaluate the feasibility of recruiting and retaining parents in a study assessing ...
S. Giva +9 more
wiley +1 more source
Association between vitamin D status and hyperinsulinism
, 2018 Some studies have suggested that vitamin D deficiency is associated with an increased risk of first trimester miscarriages, others have suggested that it is associated with an increased risk of hyperinsulinism/insulin resistance and the development of ...
Leemaqz, S. +9 more
core +1 more source
Clinical Genetics, EarlyView.We set out to characterize genotype–phenotype correlations in the recently delineated KDM2B‐associated neurodevelopmental disorder. We observe a highly penetrant CxxC domain‐related phenotype with distinct facial features supported by GestaltMatcher. In contrast, our findings point to variable expressivity and incomplete penetrance of loss‐of‐function ...
Amber S. E. van Oirsouw +30 more
wiley +1 more source