Results 51 to 60 of about 14,092 (208)
The molecular mechanisms, diagnosis and management of congenital hyperinsulinism
Indian Journal of Endocrinology and Metabolism, 2013 Congenital hyperinsulinism (CHI) is the result of unregulated insulin secretion from the pancreatic β-cells leading to severe hypoglycaemia. In these patients it is important to make an accurate diagnosis and initiate the appropriate management so as to ...
Senthil Senniappan +2 more
doaj +1 more source
Regulation of metabolism by miR-378 [PDF]
, 2014 The present invention provides a method of regulating fatty acid metabolism in a cell by contacting the cell with a modulator of miR-378 and/or miR-378* activity or expression.
Carrer, Michele, Olson, Eric N.
core +1 more source
Health Science Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background and Aims Pre‐pregnancy overweight/obese status among women with polycystic ovary syndrome (PCOS) could increase the risk of at least one adverse pregnancy outcome (APO). This study aimed to determine how pre‐pregnancy weight and PCOS impact pregnancy outcomes. Methods For the current study, we used data collected in the Tehran Lipid
Elahe Sheklabadi +6 more
wiley +1 more source
Nouveautés radiologiques dans le dépistage et le diagnostic des erreurs innées du métabolisme [PDF]
, 2005 Les maladies héréditaires du métabolisme ont acquis une place de plus en plus importante dans la pathologie pédiatrique. Leur nombre ne cesse d’augmenter au fur et à mesure de la progression des connaissances en biologie cellulaire et des progrès ...
Boddaert, Nathalie +7 more
core +1 more source
Clinical Case Reports, 2020 Advances in genomics and 18F‐DOPA PET‐CT imaging have transformed the management of infants with Congenital Hyperinsulinism. Preoperative diagnosis of focal hyperinsulinism permits limited pancreatectomy with improved clinical outcomes while knowledge of
Caroline M. Joyce +4 more
doaj +1 more source
Pregnancy, Volume 2, Issue 3, May 2026.Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld +5 more
wiley +1 more source
Orphanet Journal of Rare Diseases, 2022 Background Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infants and children, and carries a considerable risk of neurological damage and developmental delays if diagnosis and treatment are delayed. Despite rapid
Indraneel Banerjee +7 more
doaj +1 more source
Opening closed inward rectifier potassium channel doors
British Journal of Pharmacology, Volume 183, Issue 10, Page 2197-2218, May 2026.Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger +3 more
wiley +1 more source
Childhood Type II Diabetes: The Risks and Complications [PDF]
, 2015 Type II Diabetes Mellitus is an endocrine disorder that affects people of all ages. Type II Diabetes was once considered adult-onset diabetes, as it was nearly exclusively diagnosed in adults. Over the last three decades, the number of children diagnosed
Kapke, Danielle R
core +1 more source
Patologia molecular do receptor de sulfoniluréia (SUR1) [PDF]
, 2000 The sulfonylurea receptor is a subunit of the ATP-sensitive potassium channel, which is expressed in the pancreatic beta cell. The central role of this receptor in glucose-induced insulin secretion was confirmed by description that mutations in this gene
Reis, André Fernandes [UNIFESP] +1 more
core +2 more sources