Results 41 to 50 of about 10,623 (193)

Laparoscopic Surgery for Focal-Form Congenital Hyperinsulinism Located in Pancreatic Head

Frontiers in Pediatrics, 2022
Background and AimsCongenital hyperinsulinism of infancy (CHI) is a rare condition that may cause irreversible severe neurological damage in infants. For children in whom medical management fails, partial or near-total pancreatectomy is then required ...
Zhe Wen, Jieqin Wang, Qifeng Liang, Xiaopan Chang, Wen Zhang, Huilin Niu, Qiao He   +6 more
doaj   +1 more source

Identification of an ABCC8 variant in a kindred with transient diazoxide responsive hyperinsulinism

Endocrinology, Diabetes & Metabolism Case Reports
Congenital hyperinsulinism is a rare disorder characterized by hypoglycemia and inappropriately elevated insulin levels. The genetics of congenital hyperinsulinism is complex, with the most common cause being pathogenic variants in the ATP-sensitive ...
Ryan L Smith, Stephen I Stone
doaj   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Therapies and outcomes of congenital hyperinsulinism-induced hypoglycaemia

, 2019
Congenital hyperinsulinism is a rare disease, but is the most frequent cause of persistent and severe hypoglycaemia in early childhood. Hypoglycaemia caused by excessive and dysregulated insulin secretion (hyperinsulinism) from disordered pancreatic β ...
Shah, P, Nicholson, J., Salomon Estebanez, Maria, Banerjee, Indraneel, Dunne, Mark, Cosgrove, Karen   +5 more
core   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Causes and therapy of hyperinsulinism in infancy

, 2004
Hyperinsulinism in infancy is a potentially lethal condition of neonates and occurs during early childhood as well. From defects in ion channel subunit genes to lesions in the control of β-cell metabolism and anaplerosis, the causes of hyperinsulinism in
Cosgrove, Karen E., Natarajan, Anuja, Dunne, Mark J., Fernandez, Eva M., Shepherd, Ruth M.   +4 more
core   +1 more source

Congenital Hyperinsulinism India Association: An Approach to Address the Challenges and Opportunities of a Rare Disease

Medical Sciences
India’s population complexity presents varied challenges in genetic research, and while facilities have gained traction in tier-1 and -2 cities, reliance on international collaborations often delays such investigations.
Jaikumar B. Contractor, Venkatesan Radha, Krati Shah, Praveen Singh, Sunil Tadepalli, Somashekhar Nimbalkar, Viswanathan Mohan, Pratik Shah   +7 more
doaj   +1 more source

Gestational diabetes in multifetal versus singleton pregnancies: A multicenter cohort study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Gestational diabetes in multifetal pregnancies was associated with increased maternal morbidity but less adverse neonatal and long‐term offspring outcomes than in singleton pregnancies, suggesting that current diagnostic thresholds derived from singleton gestations may not fully reflect the unique metabolic and clinical characteristics of multifetal ...
Rinat Gabbay‐Benziv, Esther Maor‐Sagie, Amos Stern, Inna Bleicher, Simon Shenhav, Enav Yefet, Yifat Wiener, Michal Kovo, Maya Frank Wolf   +8 more
wiley   +1 more source

Organic hyperinsulinism [PDF]

, 1986
In the introduction a short survey is given of the history of organic hyperinsulinism,the present position of the disease and the aim of the study. Accordingly a surveyi s giveno f the pathophysiologyo f the insulins ecretion (chapter 1), the metabolism ...
Goudswaard, Willem Bastiaan, Goudswaard, Willem Bastiaan,   +1 more
core   +2 more sources

Association between vitamin D status and hyperinsulinism

, 2018
Some studies have suggested that vitamin D deficiency is associated with an increased risk of first trimester miscarriages, others have suggested that it is associated with an increased risk of hyperinsulinism/insulin resistance and the development of ...
Leemaqz, S., Claire Roberts, Shalem Leemaqz, Roberts, C., McCormack, C., Dekker, G., Gustaaf Dekker, Furness, D., Catherine McCormack, Denise Furness   +9 more
core   +1 more source