Results 31 to 40 of about 10,576 (237)

Standardised practices in the networked management of congenital hyperinsulinism: a UK national collaborative consensus

Frontiers in Endocrinology, 2023
Congenital hyperinsulinism (CHI) is a condition characterised by severe and recurrent hypoglycaemia in infants and young children caused by inappropriate insulin over-secretion.
M. G. Shaikh, A. Lucas-Herald, A. Dastamani, Maria Salomon Estebanez, S. Senniappan, N. Abid, Sumera Ahmad, Sophie Alexander, B. Avatapalle, Neelam Awan, Hester Blair, Roisin Boyle, Alexander D Chesover, B. Cochrane, Ross Craigie, A. Cunjamalay, Sarah Dearman, Paolo De Coppi, Karen Erlandson-Parry, Sarah E. Flanagan, C. Gilbert, N. Gilligan, C. Hall, J. Houghton, Ritika R Kapoor, H. McDevitt, Zainab Mohamed, K. Morgan, J. Nicholson, Ana Nikiforovski, E. O'shea, Pratik Shah, Kirsty Wilson, C. Worth, Sarah Worthington, I. Banerjee   +35 more
semanticscholar   +1 more source

Congenital hyperinsulinism in infancy and childhood: challenges, unmet needs and the perspective of patients and families

Orphanet Journal of Rare Diseases, 2022
Background Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infants and children, and carries a considerable risk of neurological damage and developmental delays if diagnosis and treatment are delayed. Despite rapid
I. Banerjee, Julie Raskin, J. Arnoux, Diva D. De León, S. Weinzimer, M. Hammer, D. Kendall, P. Thornton   +7 more
semanticscholar   +1 more source

Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism

Diabetes, 2023
Congenital hyperinsulinism (HI) is a genetic disorder in which pancreatic β-cell insulin secretion is excessive and results in hypoglycemia that, without treatment, can cause brain damage or death.
S. Peterson, Christine A. Juliana, Cameron F. Hu, Jinghua Chai, Carson Holliday, Kara Y. Chan, Ana G. Lujan Hernandez, Zoe Challocombe, Linya Wang, Zhen Han, Nikhil Haas, R. Stafford, F. Axelrod, Tom Z. Yuan, Diva D. De León, A. Sato   +15 more
semanticscholar   +1 more source

Glutamate dehydrogenase hyperinsulinism: mechanisms, diagnosis, and treatment

Orphanet Journal of Rare Diseases, 2023
Congenital hyperinsulinism (CHI) is a genetically heterogeneous disease, in which intractable, persistent hypoglycemia is induced by excessive insulin secretion and increased serum insulin concentration.
Qiao Zeng, Yanmei Sang
semanticscholar   +1 more source

Non-coding variants disrupting a tissue-specific regulatory element in HK1 cause congenital hyperinsulinism

Nature Genetics, 2022
Gene expression is tightly regulated, with many genes exhibiting cell-specific silencing when their protein product would disrupt normal cellular function1.
M. Wakeling, Nick D. L. Owens, Jessica Hopkinson, Matthew B. Johnson, J. Houghton, A. Dastamani, Christine S. Flaxman, R. Wyatt, Thomas I. Hewat, J. Hopkins, T. Laver, Rachel van Heugten, M. Weedon, E. De Franco, K. Patel, S. Ellard, N. Morgan, E. Cheesman, I. Banerjee, A. Hattersley, M. Dunne, Ivo Liat Samar S. Khadija Nuzhat Floris Catarina Birgi Barić de Vries Hassan Humayun Levy-Khademi Limbert, I. Barić, L. de Vries, S. Hassan, K. Humayun, F. Levy‐Khademi, C. Limbert, B. Rami-Merhar, V. Mericq, K. Neville, Y. Ouarezki, Ana Tangari, C. Verge, E. Wiltshire, S. Richardson, S. Flanagan   +36 more
semanticscholar   +1 more source

Natural history and neurodevelopmental outcomes in perinatal stress induced hyperinsulinism

Frontiers in Pediatrics, 2022
Objective To describe perinatal stress induced hyperinsulinism (PSIHI), determine the prevalence of neurodevelopmental differences, and identify risk factors for poor developmental prognosis.
Winnie M. Sigal, Ohoud Alzahrani, Gabriela M. Guadalupe, Herodes Guzman, J. Radcliffe, Nina H. Thomas, A. Jawad, Diva D. De León   +7 more
semanticscholar   +1 more source

New approaches to screening and management of neonatal hypoglycemia based on improved understanding of the molecular mechanism of hypoglycemia

Frontiers in Pediatrics, 2023
For the past 70 years, controversy about hypoglycemia in newborn infants has focused on a numerical “definition of neonatal hypoglycemia”, without regard to its mechanism.
Charles A. Stanley, Charles A. Stanley, Paul S. Thornton, Paul S. Thornton, Diva D. De Leon, Diva D. De Leon   +5 more
doaj   +1 more source

The Role of GLP-1 Signaling in Hypoglycemia due to Hyperinsulinism

Frontiers in Endocrinology, 2022
Incretin hormones play an important role in the regulation of glucose homeostasis through their actions on the beta cells and other tissues. Glucagon-like peptide-1 (GLP-1) and glucose dependent insulinotropic polypeptide (GIP) are the two main incretins
Melinda Danowitz, Diva D. De León
semanticscholar   +1 more source

Hyperinsulinism in a Neonate [PDF]

Pediatric Annals, 2014
A male patient was born small for gestational age (SGA) at 33 weeks with a birth weight of 1,663 grams (< 10th percentile) and length 43 cm (10th percentile) to a 38-year-old G5P4 mother by cesarean section due to non-reassuring fetal heart tones. Prior to delivery, his mother experienced decreased fetal movement and decelerations.
Michelle, Blanco, Owais, Khan, Katherine, Stanley, Joseph R, Hageman, Siri Atma W, Greeley   +4 more
openaire   +2 more sources

Global Registries in Congenital Hyperinsulinism

Frontiers in Endocrinology, 2022
Congenital hyperinsulinism (HI) is the most frequent cause of severe, persistent hypoglycemia in newborn babies and children. There are many areas of need for HI research.
Tai L. S. Pasquini, Mahlet N. Mesfin, J. Schmitt, Julie Raskin   +3 more
semanticscholar   +1 more source