Results 71 to 80 of about 14,092 (208)

Cardiometabolic Risk Assessment in a Cohort of Children and Adolescents Diagnosed with Hyperinsulinemia

Diseases
Background: Individuals with hyperinsulinemia may initially not meet any diagnostic criteria for metabolic syndrome, though displaying a higher risk of cardiovascular complications combined with obesity, diabetes, and hypertension.
Giorgio Sodero, Donato Rigante, Lucia Celeste Pane, Linda Sessa, Ludovica Quarta, Marcello Candelli, Clelia Cipolla   +6 more
doaj   +1 more source

Insulin-induced lipid binding to hemoglobin [PDF]

Journal of the Serbian Chemical Society, 2003
Under hypoglycemic conditions, concomitant hyperinsulinism causes an apparent modification of hemoglobin (Hb) which is manifested by its aggregation (Niketić et al., Clin. Chim. Acta 197 (1991) 47).
Tomašević Nenad, Nikolić Milan R., Klappe Karen, Hoekstra Dick, Niketić Vesna P.   +4 more
doaj   +1 more source

Defining Acquired Hypothalamic Obesity: An Expert Call for Unified Diagnosis and Therapeutic Action

Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 4437-4441, June 2026.
Hanneke M. van Santen, Ashley H. Shoemaker, Mehul T. Dattani, Christian L. Roth, Mohamad Maghnie, Kevin C. J. Yuen, Christine Poitou, Hermann L. Müller   +7 more
wiley   +1 more source

An OGT Missense Variant With Impaired Enzyme Activity in a Child With Severe Developmental Delay and Hepatoblastoma

American Journal of Medical Genetics Part A, Volume 200, Issue 2, Page 502-510, February 2026.
ABSTRACT O‐GlcNAc transferase (OGT) and its antagonist O‐GlcNAcase (OGA) regulate protein O‐GlcNAcylation, a highly conserved post‐translational modification involved in metabolic sensing. Pathogenic variants in the OGT gene cause an X‐linked congenital disorder of glycosylation (OGT‐CDG) presenting developmental delay, hypotonia, intellectual ...
Alfonso Manuel D'Alessio, Huijie Yuan, Leandro Raul Soria, Sara Basse Hansen, Iolanda Boffa, Paola Arena, Benedetta Attianese, Maureen. O'Sullivan, Noelle Cullinan, Lewis Pang, Daan Marinus Ferdinand van Aalten, Nicola Brunetti‐Pierri, Sally Ann Lynch   +12 more
wiley   +1 more source

Insulinoma in a Young Patient With Focal Seizures: A Case Report of a Neurological Diagnostic Challenge

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Insulinomas can mimic refractory epilepsy, leading to diagnostic delays. Hypoglycemia should be ruled out in patients with fasting‐associated focal seizures. Timely diagnosis via Whipple's triad and surgical resection offers a complete cure and reversal of neuropsychiatric symptoms.
María Valerio López, Christopher Kaleb Romero Ríos, Mohammed Zahran, Allan Mariano Bodan Campbell, Amilcar Alfaro, Jorge Chamorro Flores   +5 more
wiley   +1 more source

Congenital hyperinsulinism caused by a de novo mutation in the ABCC8 gene: a case report [PDF]

, 2018
K
Balogh, István, Balogh, Lídia, Gombos, Éva, Kappelmayer, János, Madar, László, Molnár, Zsuzsanna   +5 more
core  

Visual interpretation, not SUV ratios, is the ideal method to interpret 18F-DOPA PET scans to aid in the cure of patients with focal congenital hyperinsulinism.

PLoS ONE, 2020
IntroductionCongenital hyperinsulinism is characterized by abnormal regulation of insulin secretion from the pancreas causing profound hypoketotic hypoglycemia and is the leading cause of persistent hypoglycemia in infants and children.
Pradeep K Garg, Burton Putegnat, Lisa Truong, Courtney Reynolds, Irene Sanchez, Jonathan K Nedrelow, John Uffman, Stephen J Lokitz, Rachid Nazih, Sudha Garg, Paul S Thornton   +10 more
doaj   +1 more source

Stillbirth in pregnancies with flat OGTT: Placental clues to occult maternal dysmetabolism

International Journal of Gynecology &Obstetrics, Volume 173, Issue 2, Page 1133-1138, May 2026.
Emma Bertucci, Alessandra Danieli, Francesco Ricciardiello, Isabella Neri, Francesca Monari, Alessandro D. Genazzani, Gaetano Bulfamante, Antonio La Marca, Laura Botticelli, Fabio Facchinetti, Laura Avagliano   +10 more
wiley   +1 more source

Recurrent Hypoglycaemia Leading to Early Diagnosis of Septo‐Optic Dysplasia in a Small‐for‐Gestational‐Age Infant—A Case Report

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Septo‐optic dysplasia (SOD) is a rare condition with highly heterogenous clinical manifestations and can be a diagnostic challenge. It can present with pituitary hormone deficiencies, growth failure, visual impairment, and neurological symptoms. SOD can be diagnosed at different time points—from the prenatal period to childhood. Our team cared
Yuan Rui Leon Tan, Xiaoao Dong, Ngee Lek, Suresh Chandran, Odattil Geetha   +4 more
wiley   +1 more source

AI‐Driven Fetal Liver Echotexture Analysis

Journal of Ultrasound in Medicine, Volume 45, Issue 2, Page 301-312, February 2026.
Objectives To evaluate the performance of artificial intelligence (AI)‐based models in predicting elevated neonatal insulin levels through fetal hepatic echotexture analysis. Methods This diagnostic accuracy study analyzed ultrasound images of fetal livers from pregnancies between 37 and 42 weeks, including cases with and without gestational diabetes ...
Karine S Da Correggio, Luís Otávio Santos, Felipe S Muylaert Barroso, Roberto N Galluzzo, Thiago Z L Chaves, Aldo von Wangenheim, Alexandre S C Onofre   +6 more
wiley   +1 more source