Results 71 to 80 of about 10,576 (237)

Risk Factors for Adverse Neurodevelopment in Transient or Persistent Congenital Hyperinsulinism

Frontiers in Endocrinology, 2020
Objective Aim was to identify hypotheses why adverse neurodevelopment still occurs in children with transient or persistent hyperinsulinism despite improvements in long-term treatment options during the last decades.
M. Roeper, Roschan Salimi Dafsari, H. Hoermann, E. Mayatepek, S. Kummer, T. Meissner   +5 more
semanticscholar   +1 more source

Congenital Hyperinsulinism India Association: An Approach to Address the Challenges and Opportunities of a Rare Disease

Medical Sciences
India’s population complexity presents varied challenges in genetic research, and while facilities have gained traction in tier-1 and -2 cities, reliance on international collaborations often delays such investigations.
Jaikumar B. Contractor, Venkatesan Radha, Krati Shah, Praveen Singh, Sunil Tadepalli, Somashekhar Nimbalkar, Viswanathan Mohan, Pratik Shah   +7 more
doaj   +1 more source

Association of Post‐Oral Glucose Tolerance Test Hypoglycaemia With Clinical Features, Incident Diabetes and Mortality in the Di@bet.es Cohort

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To investigate the association of post‐oral glucose tolerance test (OGTT) hypoglycaemia with clinical features, incident diabetes and mortality. Materials and Methods This population‐based cohort study included 2924 adults (median age 49 years, 1680 women) without known diabetes who underwent a 75‐g OGTT as part of the Di@bet.es Study ...
Tomás González‐Vidal, Gemma Rojo‐Martínez, Sergio Valdés, Eva García‐Escobar, Josep Franch‐Nadal, Alfonso Calle‐Pascual, Luis Castaño, Felipe Javier Chaves, Eduard Montanya, Elsa Villa‐Fernández, Ana Victoria García, Miguel García‐Villarino, Carmen Lambert, Edelmiro Menéndez‐Torre, Elías Delgado   +14 more
wiley   +1 more source

Organic hyperinsulinism [PDF]

, 1986
In the introduction a short survey is given of the history of organic hyperinsulinism,the present position of the disease and the aim of the study. Accordingly a surveyi s giveno f the pathophysiologyo f the insulins ecretion (chapter 1), the metabolism ...
Goudswaard, Willem Bastiaan, Goudswaard, Willem Bastiaan,   +1 more
core  

Causes and therapy of hyperinsulinism in infancy

, 2004
Hyperinsulinism in infancy is a potentially lethal condition of neonates and occurs during early childhood as well. From defects in ion channel subunit genes to lesions in the control of β-cell metabolism and anaplerosis, the causes of hyperinsulinism in
Cosgrove, Karen E., Natarajan, Anuja, Dunne, Mark J., Fernandez, Eva M., Shepherd, Ruth M.   +4 more
core   +1 more source

Insulin-induced glycosylphosphatidylinositol (GPI) binding to red cell membrane proteins [PDF]

Journal of the Serbian Chemical Society, 2002
In this work GPI binding to membrane proteins from erythrocytes of insulinoma patients for whom prolonged hyperinsulinism and hypoglycemia were characteristic, as well as from normal erythrocytes incubated with supraphysiological concentrations of ...
NENAD TOMASEVIC, VESNA NIKETIC, MILAN NIKOLIC   +2 more
doaj   +3 more sources

From Multiple Congenital Anomalies to Pituitary Gland Malformation: Wide Spectrum of Clinical Features in a Family With FOXA2 Variant

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1452-1457, June 2026.
ABSTRACT FOXA2 (hepatocyte nuclear factor‐3β, HNF‐3β) encodes a transcriptional activator involved in early embryogenesis, particularly in the patterning and differentiation of midline structures such as the neural tube, foregut, and pituitary gland. Its role in human pathogenesis was first suspected when patients with deletion of chromosome 20p11.2 ...
Christopher Connolly, Hemant A. Parmar, Lauren Hipp, Tomoyasu Higashimoto   +3 more
wiley   +1 more source

Complexities in the medical management of hypoglycaemia due to congenital hyperinsulinism

Clinical Endocrinology, 2020
Congenital Hyperinsulinism (CHI) is a rare disease of hypoglycaemia but is the most common form of recurrent and severe hypoglycaemia causing brain injury and neurodisability in children.
C. Worth, D. Yau, Maria Salomon Estebanez, E. O'shea, K. Cosgrove, M. Dunne, I. Banerjee   +6 more
semanticscholar   +1 more source

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, Volume 104, Issue 6, Page 539-555, June 2026.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source

Persistent hyperinsulinism in Kabuki syndrome 2: case report and literature review

, 2016
Kabuki syndrome is a clinically and genetically heterogeneous congenital malformation syndrome with protean clinical manifestations. This reflects the important epigenetic role in embryonic development of the two genes currently known to be associated ...
Chuk, Raymond, Raymond Chuk, Coman, David, David Coman, Gole, Hobia, Hobia Gole   +5 more
core   +1 more source