Transient Neonatal Hypocortisolism in Neonates with Hypoglycemia – Coexistence or Cause?
Introduction: Infants born preterm, with low birth weight (LBW), or with perinatal stress are at high risk for neonatal hypoglycemia. Low cortisol levels have also been demonstrated in this group of neonates, which is often transient.
Sunetra Mondal+8 more
doaj +1 more source
Overweight and obese patients with nickel allergy have a worse metabolic profile compared to weight matched non-allergic individuals [PDF]
A lack of balance between energy intake and expenditure due to overeating or reduced physical activity does not seem to explain entirely the obesity epidemic we are facing, and further factors are therefore being evaluated.
Basciani, S+12 more
core +1 more source
Augmented Hypothalamic Corticotrophin-Releasing Hormone mRNA and Corticosterone Responses to Stress in Adult Rats Exposed to Perinatal Hypoxia [PDF]
Stressful events before or just after parturition alter the subsequent phenotypical response to stress in a general process termed programming. Hypoxia during the period before and during parturition, and in the postnatal period, is one of the most ...
Cullinan, William E+2 more
core +2 more sources
Maternal serum zinc and copper and infant birth weight [PDF]
Objective: Trace element deficiencies have been documented to play an important role in determination of the fetal outcome. It has been reported that the pregnant women in developing countries consume diets with a lower density of minerals and vitamins ...
انتشاری مقدم, افسانه+5 more
core
Family history in the Aetiology of Gestational Diabetes Mellitus and Type 2 Diabetes [PDF]
The aetiology of Type 2 diabetes [NIDDM] is assumed to involve a multiplicity of causal factors involving both genetic and environmental, including intrauterine, components. Aim: To identify the relationship of various aspects of family history and hence
Chircop, Marcelle+2 more
core
Insulino-resistência e aterosclerose.
The western way of life favours the development of a state of insulin resistance, in genetically predisposed subjects. In this state, greater levels of insulin are necessary so that an answer can be obtained and, consequently, hyperinsulinism occurs ...
J S Nunes, L G Correia, J N Corrêa
doaj +1 more source
iRegNet3D: three-dimensional integrated regulatory network for the genomic analysis of coding and non-coding disease mutations [PDF]
The mechanistic details of most disease-causing mutations remain poorly explored within the context of regulatory networks. We present a high-resolution three-dimensional integrated regulatory network (iRegNet3D) in the form of a web tool, where we ...
Cooper, David Neil+6 more
core +4 more sources
Unravelling the genetic causes of mosaic islet morphology in congenital hyperinsulinism
Congenital hyperinsulinism (CHI) causes dysregulated insulin secretion which can lead to life‐threatening hypoglycaemia if not effectively managed. CHI can be sub‐classified into three distinct groups: diffuse, focal and mosaic pancreatic disease. Whilst
J. Houghton+10 more
semanticscholar +1 more source
Patologia molecular do receptor de sulfoniluréia (SUR1) [PDF]
The sulfonylurea receptor is a subunit of the ATP-sensitive potassium channel, which is expressed in the pancreatic beta cell. The central role of this receptor in glucose-induced insulin secretion was confirmed by description that mutations in this gene
Reis, André Fernandes [UNIFESP]+1 more
core +2 more sources
Background: Congenital hyperinsulinism (CHI) is an inappropriate insulin secretion by the pancreatic cells. When medical therapies are ineffective, surgical treatment is required. Objective: This study aims to evaluate the clinical characteristics of CHI
Munib Ahmed Al-Zubaidi+2 more
doaj +1 more source