Results 21 to 30 of about 14,238 (246)
Journal of Parenteral and Enteral Nutrition, Volume 47, Issue 1, Page 41-50, January 2023., 2023 Abstract Background: Steatosis is a common feature of intestinal failure–associated liver disease (IFALD) in adult and older pediatric patients receiving long‐term parenteral nutrition (PN). There are limited clinical data concerning steatosis in infants with short bowel syndrome (SBS).
Riikka Gunnar +3 more
wiley +1 more source
Natural history and neurodevelopmental outcomes in perinatal stress induced hyperinsulinism
Frontiers in Pediatrics, 2022 Objective To describe perinatal stress induced hyperinsulinism (PSIHI), determine the prevalence of neurodevelopmental differences, and identify risk factors for poor developmental prognosis.
Winnie M. Sigal +7 more
semanticscholar +1 more source
The Role of GLP-1 Signaling in Hypoglycemia due to Hyperinsulinism
Frontiers in Endocrinology, 2022 Incretin hormones play an important role in the regulation of glucose homeostasis through their actions on the beta cells and other tissues. Glucagon-like peptide-1 (GLP-1) and glucose dependent insulinotropic polypeptide (GIP) are the two main incretins
Melinda Danowitz, Diva D. De León
semanticscholar +1 more source
Global Registries in Congenital Hyperinsulinism
Frontiers in Endocrinology, 2022 Congenital hyperinsulinism (HI) is the most frequent cause of severe, persistent hypoglycemia in newborn babies and children. There are many areas of need for HI research.
Tai L. S. Pasquini +3 more
semanticscholar +1 more source
The etiology of cardiac hypertrophy in infants
Scientific Reports, 2021 This study aimed to describe the variety of etiologies currently identified in infants with cardiac hypertrophy (CH) and investigate whether there is a relation with hyperinsulinism, echocardiographic characteristics and prognosis.
Raymond Stegeman +5 more
doaj +1 more source
The Use of Lanreotide in the Treatment of Congenital Hyperinsulinism.
Journal of Clinical Endocrinology and Metabolism, 2022 CONTEXT Congenital hyperinsulinism (HI) results in severe, persistent hypoglycemia and is associated with high risk of neurodevelopmental deficits. Sixty percent of HI cases are unresponsive to diazoxide, the only FDA-approved drug.
Heather Cuff +5 more
semanticscholar +1 more source
Mutations in UCP2 in congenital hyperinsulinism reveal a role for regulation of insulin secretion. [PDF]
PLoS ONE, 2008 Although the most common mechanism underlying congenital hyperinsulinism is dysfunction of the pancreatic ATP-sensitive potassium channel, the pathogenesis and genetic origins of this disease remains largely unexplained in more than half of all patients.
M Mar González-Barroso +8 more
doaj +1 more source
Pediatric Diabetes, 2022 Hyperinsulinism results from inappropriate insulin secretion during hypoglycaemia. Down syndrome is causally linked to a number of endocrine disorders including Type 1 diabetes and neonatal diabetes.
Thomas I. Hewat +15 more
semanticscholar +1 more source
Journal of Medical Case Reports, 2021 Background In neonates, rhesus D alloimmunization despite anti-D immunoglobulin prophylaxis is rare and often unexplained. Rhesus D alloimmunization can lead to hemolytic disease of the newborn with anemia and unconjugated hyperbilirubinemia.
Sandra Simony Tornoe Riis +8 more
doaj +1 more source
SUR1-mutant iPS cell-derived islets recapitulate the pathophysiology of congenital hyperinsulinism
Diabetologia, 2021 Congenital hyperinsulinism caused by mutations in the KATP-channel-encoding genes (KATPHI) is a potentially life-threatening disorder of the pancreatic beta cells. No optimal medical treatment is available for patients with diazoxide-unresponsive diffuse
Väinö Lithovius +6 more
semanticscholar +1 more source