Results 21 to 30 of about 20,887 (300)
International Guidelines for the Diagnosis and Management of Hyperinsulinism
Hormone Research in Paediatrics, 2023 Background: Hyperinsulinism (HI) due to dysregulation of pancreatic beta-cell insulin secretion is the most common and most severe cause of persistent hypoglycemia in infants and children.
Diva D. De León +16 more
semanticscholar +1 more source
Syndromic forms of congenital hyperinsulinism
Frontiers in Endocrinology, 2023 Congenital hyperinsulinism (CHI), also called hyperinsulinemic hypoglycemia (HH), is a very heterogeneous condition and represents the most common cause of severe and persistent hypoglycemia in infancy and childhood.
M. Zenker, K. Mohnike, Katja Palm
semanticscholar +1 more source
Frontiers in Pediatrics, 2021 Focal hyperinsulinism (HI) comprises nearly 50% of all surgically treated HI cases and is cured if the focal lesion can be completely resected. Pre-operative localization of the lesion is thus critical.
Elizabeth Rosenfeld +29 more
doaj +1 more source
Frontiers in Endocrinology, 2023 Congenital hyperinsulinism (CHI) is a condition characterised by severe and recurrent hypoglycaemia in infants and young children caused by inappropriate insulin over-secretion.
M. G. Shaikh +35 more
semanticscholar +1 more source
Glutamate dehydrogenase hyperinsulinism: mechanisms, diagnosis, and treatment
Orphanet Journal of Rare Diseases, 2023 Congenital hyperinsulinism (CHI) is a genetically heterogeneous disease, in which intractable, persistent hypoglycemia is induced by excessive insulin secretion and increased serum insulin concentration.
Qiao Zeng, Yanmei Sang
semanticscholar +1 more source
Nature Genetics, 2022 Gene expression is tightly regulated, with many genes exhibiting cell-specific silencing when their protein product would disrupt normal cellular function1.
M. Wakeling +36 more
semanticscholar +1 more source
The Role of GLP-1 Signaling in Hypoglycemia due to Hyperinsulinism
Frontiers in Endocrinology, 2022 Incretin hormones play an important role in the regulation of glucose homeostasis through their actions on the beta cells and other tissues. Glucagon-like peptide-1 (GLP-1) and glucose dependent insulinotropic polypeptide (GIP) are the two main incretins
Melinda Danowitz, Diva D. De León
semanticscholar +1 more source
The hypoglycaemia error grid: A UK-wide consensus on CGM accuracy assessment in hyperinsulinism
Frontiers in Endocrinology, 2022 Objective Continuous Glucose Monitoring (CGM) is gaining in popularity for patients with paediatric hypoglycaemia disorders such as Congenital Hyperinsulinism (CHI), but no standard measures of accuracy or associated clinical risk are available.
C. Worth +7 more
semanticscholar +1 more source
Natural history and neurodevelopmental outcomes in perinatal stress induced hyperinsulinism
Frontiers in Pediatrics, 2022 Objective To describe perinatal stress induced hyperinsulinism (PSIHI), determine the prevalence of neurodevelopmental differences, and identify risk factors for poor developmental prognosis.
Winnie M. Sigal +7 more
semanticscholar +1 more source