Results 21 to 30 of about 20,640 (292)
Frontiers in Pediatrics, 2023 For the past 70 years, controversy about hypoglycemia in newborn infants has focused on a numerical “definition of neonatal hypoglycemia”, without regard to its mechanism.
Charles A. Stanley +5 more
doaj +1 more source
The hypoglycaemia error grid: A UK-wide consensus on CGM accuracy assessment in hyperinsulinism
Frontiers in Endocrinology, 2022 Objective Continuous Glucose Monitoring (CGM) is gaining in popularity for patients with paediatric hypoglycaemia disorders such as Congenital Hyperinsulinism (CHI), but no standard measures of accuracy or associated clinical risk are available.
C. Worth +7 more
semanticscholar +1 more source
The p.(Gly111Arg) ABCC8 Variant: A Founder Mutation Causing Congenital Hyperinsulinism in the Indian Agarwal Community. [PDF]
Clin GenetLoss‐of‐function ABCC8 variants are the commonest cause of congenital hyperinsulinism. On a systematic search of our databases, the p.(Gly111Arg) ABCC8 variant was identified in 26 individuals, of which 23 were from the Indian Agarwal community. Haplotype analysis subsequently confirmed that p.(Gly111Arg) is a founder variant in the Agarwal population.
Jain V +5 more
europepmc +2 more sources
The Role of GLP-1 Signaling in Hypoglycemia due to Hyperinsulinism
Frontiers in Endocrinology, 2022 Incretin hormones play an important role in the regulation of glucose homeostasis through their actions on the beta cells and other tissues. Glucagon-like peptide-1 (GLP-1) and glucose dependent insulinotropic polypeptide (GIP) are the two main incretins
Melinda Danowitz, Diva D. De León
semanticscholar +1 more source
Global Registries in Congenital Hyperinsulinism
Frontiers in Endocrinology, 2022 Congenital hyperinsulinism (HI) is the most frequent cause of severe, persistent hypoglycemia in newborn babies and children. There are many areas of need for HI research.
Tai L. S. Pasquini +3 more
semanticscholar +1 more source
Natural history and neurodevelopmental outcomes in perinatal stress induced hyperinsulinism
Frontiers in Pediatrics, 2022 Objective To describe perinatal stress induced hyperinsulinism (PSIHI), determine the prevalence of neurodevelopmental differences, and identify risk factors for poor developmental prognosis.
Winnie M. Sigal +7 more
semanticscholar +1 more source
The Use of Lanreotide in the Treatment of Congenital Hyperinsulinism.
Journal of Clinical Endocrinology and Metabolism, 2022 CONTEXT Congenital hyperinsulinism (HI) results in severe, persistent hypoglycemia and is associated with high risk of neurodevelopmental deficits. Sixty percent of HI cases are unresponsive to diazoxide, the only FDA-approved drug.
Heather Cuff +5 more
semanticscholar +1 more source
The etiology of cardiac hypertrophy in infants
Scientific Reports, 2021 This study aimed to describe the variety of etiologies currently identified in infants with cardiac hypertrophy (CH) and investigate whether there is a relation with hyperinsulinism, echocardiographic characteristics and prognosis.
Raymond Stegeman +5 more
doaj +1 more source
Frontiers in Endocrinology, 2022 Congenital hyperinsulinism (HI) is a rare disease affecting newborns. HI causes severe hypoglycemia due to the overproduction of insulin. The signs and symptoms of hypoglycemia in HI babies is often not discovered until brain damage has already occurred.
Julie Raskin +4 more
semanticscholar +1 more source
Mutations in UCP2 in congenital hyperinsulinism reveal a role for regulation of insulin secretion. [PDF]
PLoS ONE, 2008 Although the most common mechanism underlying congenital hyperinsulinism is dysfunction of the pancreatic ATP-sensitive potassium channel, the pathogenesis and genetic origins of this disease remains largely unexplained in more than half of all patients.
M Mar González-Barroso +8 more
doaj +1 more source