Results 31 to 40 of about 20,887 (300)

New approaches to screening and management of neonatal hypoglycemia based on improved understanding of the molecular mechanism of hypoglycemia

Frontiers in Pediatrics, 2023
For the past 70 years, controversy about hypoglycemia in newborn infants has focused on a numerical “definition of neonatal hypoglycemia”, without regard to its mechanism.
Charles A. Stanley, Charles A. Stanley, Paul S. Thornton, Paul S. Thornton, Diva D. De Leon, Diva D. De Leon   +5 more
doaj   +1 more source

Global Registries in Congenital Hyperinsulinism

Frontiers in Endocrinology, 2022
Congenital hyperinsulinism (HI) is the most frequent cause of severe, persistent hypoglycemia in newborn babies and children. There are many areas of need for HI research.
Tai L. S. Pasquini, Mahlet N. Mesfin, J. Schmitt, Julie Raskin   +3 more
semanticscholar   +1 more source

Obstructive sleep apnea is associated with impaired insulin clearance and hepatic insulin sensitivity in paediatric obesity. [PDF]

Diabetes Obes Metab
Abstract Aims Obstructive sleep apnea (OSA) affects up to 40% of children and adolescents with obesity and is linked to hyperinsulinism. However, the mechanisms underpinning this association remain unclear. The study aims to assess the three key determinants of hyperinsulinemia: insulin clearance, secretion, and sensitivity in paediatric patients with ...
Umano GR, Aiello F, Rondinelli G, Salvati A, Petrone D, Sibillo MV, D'Ausilio R, Marzuillo P, Grandone A, Cirillo G, Tricò D, Del Giudice EM.   +11 more
europepmc   +2 more sources

Congenital Hyperinsulinism International: A Community Focused on Improving the Lives of People Living With Congenital Hyperinsulinism

Frontiers in Endocrinology, 2022
Congenital hyperinsulinism (HI) is a rare disease affecting newborns. HI causes severe hypoglycemia due to the overproduction of insulin. The signs and symptoms of hypoglycemia in HI babies is often not discovered until brain damage has already occurred.
Julie Raskin, Tai L. S. Pasquini, Sheila Bose, Dina Tallis, J. Schmitt   +4 more
semanticscholar   +1 more source

The etiology of cardiac hypertrophy in infants

Scientific Reports, 2021
This study aimed to describe the variety of etiologies currently identified in infants with cardiac hypertrophy (CH) and investigate whether there is a relation with hyperinsulinism, echocardiographic characteristics and prognosis.
Raymond Stegeman, Nina D. Paauw, Rosalie de Graaf, Rosa L. E. van Loon, Jacqueline U. M. Termote, Johannes M. P. J. Breur   +5 more
doaj   +1 more source

Genetics of neonatal hyperinsulinism [PDF]

Archives of Disease in Childhood - Fetal and Neonatal Edition, 2000
Congenital hyperinsulinism (HI) is a clinically and genetically heterogeneous entity. The clinical heterogeneity is manifested by severity ranging from extremely severe, life threatening disease to very mild clinical symptoms, which may even be difficult to identify.
Benjamin Gläser, Paul Thornton, Timo Otonkoski, Claudine Junien   +3 more
openalex   +4 more sources

The Use of Lanreotide in the Treatment of Congenital Hyperinsulinism.

Journal of Clinical Endocrinology and Metabolism, 2022
CONTEXT Congenital hyperinsulinism (HI) results in severe, persistent hypoglycemia and is associated with high risk of neurodevelopmental deficits. Sixty percent of HI cases are unresponsive to diazoxide, the only FDA-approved drug.
Heather Cuff, K. Lord, Lance Ballester, T. Scully, N. Stewart, Diva D. De León   +5 more
semanticscholar   +1 more source

Mutations in UCP2 in congenital hyperinsulinism reveal a role for regulation of insulin secretion. [PDF]

PLoS ONE, 2008
Although the most common mechanism underlying congenital hyperinsulinism is dysfunction of the pancreatic ATP-sensitive potassium channel, the pathogenesis and genetic origins of this disease remains largely unexplained in more than half of all patients.
M Mar González-Barroso, Irina Giurgea, Fredéric Bouillaud, Andrea Anedda, Christine Bellanné-Chantelot, Laurence Hubert, Yves de Keyzer, Pascale de Lonlay, Daniel Ricquier   +8 more
doaj   +1 more source

Increased referrals for congenital hyperinsulinism genetic testing in children with trisomy 21 reflects the high burden of non‐genetic risk factors in this group

Pediatric Diabetes, 2022
Hyperinsulinism results from inappropriate insulin secretion during hypoglycaemia. Down syndrome is causally linked to a number of endocrine disorders including Type 1 diabetes and neonatal diabetes.
Thomas I. Hewat, T. Laver, J. Houghton, Jonna M E Männistö, S. Alvi, Stephen P. Brearey, D. Cody, A. Dastamani, Miguel De Los Santos La Torre, N. Murphy, B. Rami-Merhar, Birgit Wefers, H. Huopio, I. Banerjee, Matthew B. Johnson, S. Flanagan   +15 more
semanticscholar   +1 more source

Transient congenital hyperinsulinism and hemolytic disease of a newborn despite rhesus D prophylaxis: a case report

Journal of Medical Case Reports, 2021
Background In neonates, rhesus D alloimmunization despite anti-D immunoglobulin prophylaxis is rare and often unexplained. Rhesus D alloimmunization can lead to hemolytic disease of the newborn with anemia and unconjugated hyperbilirubinemia.
Sandra Simony Tornoe Riis, Marianne Hoerby Joergensen, Kristina Fruerlund Rasmussen, Steffen Husby, Jane Preuss Hasselby, Lise Borgwardt, Klaus Brusgaard, Christina Ringmann Fagerberg, Henrik Thybo Christesen   +8 more
doaj   +1 more source