Results 11 to 20 of about 990,113 (271)

Identification of an apoC-II variant (apoC-IIBethesda) in a kindred with apoC-II deficiency and type I hyperlipoproteinemia.

Journal of Lipid Research, 1988
Apolipoprotein (apo) C-II deficiency is characterized by elevated plasma triglycerides, chylomicrons, and very low density lipoproteins, as well as reduced levels of low density and high density lipoproteins.
D L Sprecher, L Taam, R E Gregg, S S Fojo, D M Wilson, M L Kashyap, H B Brewer, Jr   +6 more
doaj   +2 more sources

Alternative cascade-testing protocols for identifying and managing patients with familial hypercholesterolaemia: systematic reviews, qualitative study and cost-effectiveness analysis

Health Technology Assessment, 2023
Background Cascade testing the relatives of people with familial hypercholesterolaemia is an efficient approach to identifying familial hypercholesterolaemia.
Nadeem Qureshi, Bethan Woods, Rita Neves de Faria, Pedro Saramago Goncalves, Edward Cox, Jo Leonardi-Bee, Laura Condon, Stephen Weng, Ralph K Akyea, Barbara Iyen, Paul Roderick, Steve E Humphries, William Rowlands, Melanie Watson, Kate Haralambos, Ryan Kenny, Dev Datta, Zosia Miedzybrodzka, Christopher Byrne, Joe Kai   +19 more
doaj   +2 more sources

Isolation and characterization of an apoA-II-containing lipoprotein (LP-A-II:B complex) from plasma very low density lipoproteins of patients with Tangier disease and type V hyperlipoproteinemia.

Journal of Lipid Research, 1991
Previous studies have shown that very low density lipoproteins (VLDL) from patients with Tangier disease are less effective as a substrate for human milk lipoprotein lipase (LPL) than VLDL from normal controls as assessed by measuring the first order ...
P Alaupovic, C Knight-Gibson, CS Wang, D Downs, E Koren, HB Brewer, Jr, RE Gregg   +6 more
doaj   +2 more sources

Premature development of iliac artery stenosis in asymptomatic type II hyperlipoproteinemia. [PDF]

Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1984
There is conflicting evidence on the relationship between increased low density lipoprotein (LDL) concentration in Type II hyperlipoproteinemia and premature development of peripheral atherosclerosis of the lower limbs. We evaluated the early signs of iliac artery involvement in patients with asymptomatic Type II hyperlipoproteinemia. Of these, 23 were
Paolo Rubba, A. Postiglione, Barbieri Simone, F. Faccenda, Gabriele Riccardi, Mario Mancini   +5 more
openalex   +5 more sources

2022 Consensus statement on the management of familial hypercholesterolemia in Korea [PDF]

The Korean Journal of Internal Medicine, 2022
Familial hypercholesterolemia (FH) is the most common monogenic disorder. Due to the marked elevation of cardiovascular risk, the early detection, diagnosis, and proper management of this disorder are critical.
Chan Joo Lee, Minjae Yoon, Hyun-Jae Kang, Byung Jin Kim, Sung Hee Choi, In-Kyung Jeong, Sang-Hak Lee   +6 more
doaj   +1 more source

Dynamic, Interpretable, Machine Learning-Based Outcome Prediction as a New Emerging Opportunity in Acute Ischemic Stroke Patient Care: A Proof-of-Concept Study. [PDF]

Stroke Res Treat
Introduction: While the machine learning (ML) model’s black‐box nature presents a significant barrier to effective clinical application, the dynamic nature of stroke patients’ recovery further undermines the reliability of established predictive scores and models, making them less suitable for accurate prediction and appropriate patient care.
Petrović I, Njegovan S, Tomašević O, Vlahović D, Rajić S, Živanović Ž, Milosavljević I, Balenović A, Jorgovanović N.   +8 more
europepmc   +2 more sources

Role of PCSK9 Inhibitors in Patients with Familial Hypercholesterolemia [PDF]

Endocrinology and Metabolism, 2021
Patients with familial hypercholesterolemia (FH) are at high or very high risk for cardiovascular disease. Those with heterozygous FH (HeFH) often do not reach low-density lipoprotein cholesterol (LDL-C) targets with statin and ezetimibe therapy, and ...
Brian Tomlinson, Nivritti Gajanan Patil, Manson Fok, Christopher Wai Kei Lam   +3 more
doaj   +1 more source

Familial hypercholesterolemia within cardiology practice – single-center experience during 2-year period

Research in Cardiovascular Medicine, 2022
Background: Familial hypercholesterolemia (FH) is an inherited disorder characterized by significantly elevated levels of low-density lipoprotein (LDL) cholesterol and is usually diagnosed after the occurrence of major adverse cardiovascular event.
Edin Begic, Ada Djozic, Emina Karavelic, Nadira Zatric, Adela Sinancevic, Alen Dzubur, Azra Durak-Nalbantic, Alden Begic, Nedim Begic, Amina Sahbaz, Esma Hasanagic, Ena Gogic, Nabil Naser, Fuad Zukic, Edin Medjedovic, Amer Iglica, Mirela Halilcevic, Zijo Begic   +17 more
doaj   +1 more source

Genetic and molecular architecture of familial hypercholesterolemia

Journal of Internal Medicine, Volume 293, Issue 2, Page 144-165, February 2023., 2023
Abstract Atherosclerotic cardiovascular disease is the leading cause of death globally. Despite its important risk of premature atherosclerosis and cardiovascular disease, familial hypercholesterolemia (FH) is still largely underdiagnosed worldwide. It is one of the most frequently inherited diseases due to mutations, for autosomal dominant forms, in ...
Marianne Abifadel, Catherine Boileau
wiley   +1 more source

Eruptive Xanthomas Caused by Primary Type V Hyperlipoproteinemia

Internal medicine, 2021
A 39-year-old man (height, 170 cm; weight, 105 kg; body mass index, 36.3 kg/m) with dyslipidemia (no family history) and type II diabetes mellitus treated with 50 mg ipragliflozin, 1,500 mg metformin, and 0.2 mg pemafibrate was referred to our clinic. On
Yoshihiro Nakamura, Tsuyoshi Watanabe, N. Takizawa, Yoshiro Fujita   +3 more
semanticscholar   +1 more source