Results 41 to 50 of about 3,031 (200)

A Randomized, Double‐Blind, Placebo‐Controlled, Phase 1 Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of Single Vaccination of Ad26.RSV.preF‐Based Regimen in Japanese Adults Aged 60 Years and Older

Influenza and Other Respiratory Viruses, Volume 18, Issue 6, June 2024.
ABSTRACT Background Respiratory syncytial virus (RSV) is increasingly recognized as a significant cause of lower respiratory tract disease (LRTD) in older adults. The Ad26.RSV.preF/RSV preF protein vaccine demonstrated protective efficacy against RSV related LRTD in a Phase 2b study in the United States.
Takashi Eto, Yusuke Okubo, Atsushi Momose, Hiroshi Tamura, Richuan Zheng, Benoit Callendret, Arangassery Rosemary Bastian, Christy A. Comeaux   +7 more
wiley   +1 more source

Sanghuangporus vaninii extract ameliorates hyperlipidemia in rats by mechanisms identified with transcriptome analysis

Food Science &Nutrition, Volume 12, Issue 5, Page 3360-3376, May 2024.
Extracts of Sanghuangporus vaninii can relieve hyperlipidemia in rats. The results of transcriptomic analysis indicated that S. vaninii extract can activate the AMPK signaling pathway, which subsequently promotes the metabolism of lipids and inhibits the biosynthesis of cholesterol, meanwhile facilitating the excretion of cholesterol, exciting the ...
Ning Gao, Yuanzhen Liu, Guangjie Liu, Bo Liu, Yupeng Cheng   +4 more
wiley   +1 more source

Chronic heart failure induces early defenestration of liver sinusoidal endothelial cells (LSECs) in mice

Acta Physiologica, Volume 240, Issue 5, May 2024.
Abstract Aim Chronic heart failure (CHF) is often linked to liver malfunction and systemic endothelial dysfunction. However, whether cardio‐hepatic interactions in heart failure involve dysfunction of liver sinusoidal endothelial cells (LSECs) is not known.
Kamila Wojnar‐Lason, Urszula Tyrankiewicz, Agnieszka Kij, Anna Kurpinska, Patrycja Kaczara, Grzegorz Kwiatkowski, Natalia Wilkosz, Magdalena Giergiel, Marta Stojak, Marek Grosicki, Tasnim Mohaissen, Agnieszka Jasztal, Zuzanna Kurylowicz, Marek Szymonski, Izabela Czyzynska‐Cichon, Stefan Chlopicki   +15 more
wiley   +1 more source

Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia): questions, quandaries, and paradoxes

Journal of Lipid Research, 1999
Type III hyperlipoproteinemia (HLP) is a genetic disorder characterized by accumulation of remnant lipoproteins in the plasma and development of premature atherosclerosis. Although receptor binding-defective forms of apolipoprotein (apo) E are the common
Robert W. Mahley, Yadong Huang, Stanley C. Rall, Jr.   +2 more
doaj  

Apolipoprotein E isoforms and their Cys‐thiol modifications impact LRP1‐mediated metabolism of triglyceride‐rich lipoproteins

FEBS Letters, Volume 598, Issue 3, Page 347-362, February 2024.
The current study offers a novel perspective on the physiological role of apolipoprotein (apo) E in lipid metabolism. The redox status of Cys‐thiol in the apoE molecule significantly influences lipoprotein metabolism via the low‐density lipoprotein receptor‐related protein (LRP) 1. Our findings are instrumental in understanding the pathology of various
Hiroto Matsuura, Shogo Akahane, Takahiro Kaido, Tomu Kamijo, Kenta Sakamoto, Kazuyoshi Yamauchi   +5 more
wiley   +1 more source

Yellow palms and feet in a child

Russian Open Medical Journal, 2014
The yellowish discoloration of the palms and skin is reported under different terms: xanthodermia, hypercarotenemia, carotenemia, carotenodermia. Yellow discoloration of the skin may be associated with carotenemia, hypothyroidism, diabetes mellitus ...
Anca Chiriac, Anca E. Chiriac, Tudor Pinteala, Elena Gologan, Caius Solovan, Piotr Brzezinski   +5 more
doaj  

Thrombin binding and response in platelets from patients with dyslipoproteinemias: increased stimulus-response coupling in type II hyperlipoproteinemia [PDF]

, 1986
JT Harmon, NN Tandon, JM Hoeg, GA Jamieson   +3 more
openalex   +3 more sources

Hepatic cholesterol metabolism in normo- and hyperlipidemic patients with cholesterol gallstones.

Journal of Lipid Research, 1979
In vivo studies have shown abnormalities in cholesterol and bile acid metabolism in primary hyperlipoproteinemia (HLP). The aim of the present investigation was to determine if the increased production of cholesterol in HLP type IV can be attributed to a
J Ahlberg, B Angelin, I Björkhem, K Einarsson, B Leijd   +4 more
doaj  

Quantitation of human apolipoprotein C-III and its subspecie by radioimmunoassay and analytical isoelectric focusing: abnormal plasma triglyceride-rich lipoprotein apolipoprotein C-III subspecie concentrations in hypertriglyceridemia.

Journal of Lipid Research, 1981
A specific, accurate, and sensitive double antibody radioimmunoassay for measuring human apolipoprotein (apo) C-III has been developed. Anti-apoC-III(1) developed in rabbits cross-reacted completely with apoC-III subspecies.
M L Kashyap, L S Srivastava, B A Hynd, P S Gartside, G Perisutti   +4 more
doaj  

Tuberous Xanthoma in Homozygous Type II Hyperlipoproteinemia

, 2023
Bernadine H. Bulkley, L. Maximilian Buja, Victor J. Ferrans, Gregory B. Bulkley, William C. Roberts   +4 more
openalex   +1 more source