Results 61 to 70 of about 9,955 (227)

Protective Effects of Quercetin on Oxidative Stress-Induced Tubular Epithelial Damage in the Experimental Rat Hyperoxaluria Model

Medicina, 2021
Background and Objectives: The most common kidney stones are calcium stones and calcium oxalate (CaOx) stones are the most common type of calcium stones. Hyperoxaluria is an essential risk factor for the formation of these stones.
Ahmet Guzel, Sedat Yunusoglu, Mustafa Calapoglu, Ibrahim Aydın Candan, Ibrahim Onaran, Meral Oncu, Osman Ergun, Taylan Oksay   +7 more
doaj   +1 more source

Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease

Advanced Materials, Volume 38, Issue 17, 20 March 2026.
RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley   +1 more source

سه بار شکستگی هيپ در يک کودک مبتلا به هيپراگزالوريا اوليه [PDF]

, 2011
زمينه و هدف : هيپراگزالوريا اوليه از علل ايجاد سنگهای متعدد کليوی و نارسائی کليه در سنين پائين می باشد. تغييرات استخوانی بوجود آمده در اين بيماران شامل دو دسته کلی اگزالوسيس استخوان و استئوديستروفی رنال می باشد.
متقی, آرش, ياوری‌کيا, علیرضا, کيهان شکوه, حسن   +2 more
core  

Risk factors evaluation for urolithiasis among children [PDF]

, 1978
BackgroundThe prevalence of pediatric urolithiasis varies from 0.01–0.03%. Urolithiasis may be caused by anatomical, metabolic and environmental factors.
Velásquez-Forero, Francisco, Esparza, Mariela, Salas, Alejandro, Medeiros, Mara, Toussaint, Georgina, Llach, Francisco   +5 more
core   +2 more sources

Identifying recurrent stone formers with machine learning: A single‐centre observational study

BJUI Compass, Volume 7, Issue 3, March 2026.
Abstract Objectives Kidney stones affect 12% of the population over their lifetime. Recurrent kidney stones lead to repeated interventions and excessive healthcare costs. Despite progress in imaging and metabolic evaluations, models to accurately identify patients at high risk are missing.
Pedro Amado, Daniel G. Fuster, Matteo Bargagli, Dominik Obrist, Fiona Burkhard, Beat Roth, Francesco Clavica, Shaokai Zheng   +7 more
wiley   +1 more source

A case of failure to thrive secondary to primary hyperoxaluria type 1

Radiology Case Reports, 2020
Primary hyperoxaluria type 1 is a rare genetic condition characterized by oxalate deposition in the kidneys. We report findings of an 8-month old female presenting with failure to thrive, poor oral intake, and kidney stones resulting in the diagnosis of ...
Rachel Stern, MD, Vicky Kuo, MD, Sarah Rogal, MD, MPH, Carly Barron, MD, Raidour Ahmed, MD, Bernard Goldwasser, MD   +5 more
doaj   +1 more source

Medicine Development and Access for Rare Diseases: Can We Do Better?

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Recent advances in molecular biology and genomics have significantly enhanced our understanding of rare diseases. While enabling the development of highly targeted therapies, it also leads to complexity in the development, regulation, and accessibility of orphan medicines.
Carla E. M. Hollak, Noa Rosenberg, Colinda Post, Nina Stolwijk, Evert Manders, Daphne Schoenmakers, Bart Penninx, Niels Reijnhout, Kathelijn Verdeyen, Roel Jonker, Annet M. Bosch, Mirjam Langeveld, Vincent van der Wel, Saco de Visser, Sibren van den Berg   +14 more
wiley   +1 more source

RNA‐Based Therapies for Inherited Metabolic Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Inherited metabolic disorders (IMDs) are a diverse and complex group of genetic conditions resulting from deficiencies in enzymes, transporters, or cofactors. These deficiencies lead to metabolic dysfunction and severe clinical consequences. Despite significant progress in understanding their molecular basis, treatment options remain limited ...
Reddy Sreekanth Vootukuri, Sonam Gurung, Roopkatha Ghosh, Philippa B. Mills, Julien Baruteau, Haiyan Zhou   +5 more
wiley   +1 more source

Az étrend szerepe a húgyúti kövek kialakulásában és megelőzésében [PDF]

, 2017
In Hungary and in the developed countries urinary stones occur more often due to nutritional habits, obesity and sedentary lifestyle beside the endocrine and metabolic causes.
Bánfi, Gergely, Horváth, András, Horváth, Csaba, Nyirády, Péter, Szendrői, Attila, Tordé, Ákos, Vargha, Judit   +6 more
core   +2 more sources

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, Volume 22, Issue 16, 17 March 2026.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source