Results 41 to 50 of about 6,717 (218)

Oxalate as a potent promoter of kidney stone formation

Frontiers in Medicine, 2023
Kidney stones are among the most prevalent urological diseases, with a high incidence and recurrence rate. Treating kidney stones has been greatly improved by the development of various minimally invasive techniques.
Tao Chen, Tao Chen, Tao Chen, Biao Qian, Biao Qian, Junrong Zou, Junrong Zou, Peiyue Luo, Peiyue Luo, Peiyue Luo, Jun Zou, Jun Zou, Jun Zou, Wei Li, Wei Li, Wei Li, Qi Chen, Qi Chen, Qi Chen, Liying Zheng   +19 more
doaj   +1 more source

Salicylic Acid Derivatives Inhibit Oxalate Production in Mouse Hepatocytes with Primary Hyperoxaluria Type 1

, 2018
Primary hyperoxaluria type 1 (PH1) is a rare life-threatening genetic disease related to glyoxylate metabolism and characterized by accumulation of calcium oxalate crystals.
Moya-Garzón, María Dolores, Salido, Eduardo, Gómez-Vidal, José A, Martín Higueras, Cristina, Fernandes, Miguel X., Díaz-Gavilán, Mónica, Romera, Manuela, Peñalver, Pablo, Franco-Montalbán, Francisco   +8 more
core   +1 more source

Hyperoxaluria with hyperglycoluria not due to alanine:glyoxylate aminotransferase defect: A novel type of primary hyperoxaluria.

, 1996
Hyperoxaluria with hyperglycoluria not due to alanine:glyoxylate aminotransferase defect: A novel type of primary hyperoxaluria. Considering the clinical heterogeneity of primary hyperoxaluria type I (PH1) and the fact that in many instances this ...
van Acker, K. J., Roels, Frank, Espeel, Marc F., WANDERS, RJA, Dekker, C., Kerckaert, Ingrid O., Kerckaert, I. O., Espeel, M. F., Dekker, Conny, Espeel, Marc, EYSKENS, FJ, van Acker, Karel J.M., Eyskens, F. J., Eyskens, François J., Van Acker, Karel J., Eyskens, Fran\ue7ois, Wanders, Ronald J.A., Roels, F., VANACKER, KJ, DEKKER, C, Wanders, R. J., Kerckaert, Ingrid   +21 more
core   +1 more source

End Points for Clinical Trials in Primary Hyperoxaluria

, 2020
Patients with primary hyperoxaluria experience kidney stones from a young age and can develop progressive oxalate nephropathy. Progression to kidney failure often develops over a number of years, and is associated with systemic oxalosis, intensive ...
Milliner, Dawn S., Dehmel, Bastian, John Knight, Melanie Blank, Blank, Melanie, Jaap Groothoff, Knight, John, Sonia Fargue, W. Todd Lowther, Sixun Yang, West, Melissa, Lieske, John C., Dawn S. Milliner, Tracy L. McGregor, Ralf Rosskamp, Yang, Sixun, Fargue, Sonia, Thompson, Aliza, Lowther, W. Todd, Kim Hollander, Groothoff, Jaap, Rosskamp, Ralf, Aliza Thompson, Bastian Dehmel, Hollander, Kim, Meaghan Allain, Rumsby, Gill, McGregor, Tracy L., Allain, Meaghan, Gill Rumsby, John C. Lieske, Melissa West   +31 more
core   +1 more source

Protective effects of ethanolic extract of Cuscuta reflexa Roxb. against ethylene glycol-induced hyperoxaluria and urolithiasis in rats [PDF]

Journal of HerbMed Pharmacology
Introduction: Renal urolithiasis is a prevalent global health concern due to its high recurrence rate. Cuscuta reflexa (Roxb) has been traditionally used for its anti-inflammatory and antioxidant properties.
Madan L. Kaushik, Nishant Goutam, Mahendra Singh Ashawat   +2 more
doaj   +1 more source

Vitamin B6 metabolites in idiopathic calcium stone formers: no evidence for a link to hyperoxaluria [PDF]

, 2004
Vitamin B6 metabolites and their potential correlates to urinary oxalate excretion in idiopathic calcium stone formers (ICSF) compared with healthy subjects were investigated.
Casez, Jean-Paul, Jaeger, Philippe, Kaelin, Agnes   +2 more
core   +1 more source

Etiologies, Clinical Features, and Outcome of Oxalate Nephropathy

Kidney International Reports, 2020
Background: Oxalate nephropathy is a potentially underestimated cause of kidney failure characterized by massive deposition of calcium oxalate crystals in the renal parenchyma.
Benoit Buysschaert, Selda Aydin, Johann Morelle, Valentine Gillion, Michel Jadoul, Nathalie Demoulin, MD   +5 more
doaj   +1 more source

Expanding the Utility of Exome Sequencing in Preventive and Population Genetics

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Carrier screening is a long‐standing genetic testing process offered to at‐risk couples, with or without a family history, who might have pregnancies affected by an autosomal recessive (AR) or X‐linked (XL) disorder. A total of 276 unrelated individuals, initially referred for rare disorder screening by clinicians, were enrolled in this study ...
Charilaos Kostoulas, Athanasia Sesse, Ioanna Bouba, Robert Najdecki, Spyridon Konitsiotis, Sofia Markoula, Ioannis Georgiou   +6 more
wiley   +1 more source

Decoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe

British Journal of Clinical Pharmacology, EarlyView.
Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...
Olivia C. Lewis, Christine Leopold, Joyce M. Hoek, Raymond M. Schiffelers, Marie L. De Bruin   +4 more
wiley   +1 more source

Enteric hyperoxaluria in chronic pancreatitis

, 2017
Chronic pancreatitis may lead to steatorrhea, enteric hyperoxaluria, and kidney damage. However, the prevalence and determinants of hyperoxaluria in chronic pancreatitis patients as well as its association with renal function decline have not been ...
Jadoul, Michel, Nathalie Demoulin, Etienne Danse, Pierre Wallemacq, Wallemacq, Pierre, Demoulin, Nathalie, Deprez, Pierre Henri, Michel Jadoul, Pierre H. Deprez, Johann Morelle, Ralph Crott, Crott, Ralph, Zaina Issa, Danse, Etienne, Issa, Zaina, Morelle, Johann   +15 more
core   +1 more source