Results 21 to 30 of about 6,717 (218)

Hydrogen Sulfide Deficiency Contributes to Tubular Damage and Calcium Oxalate Crystal Formation in Hyperoxaluria Nephropathy: Role of Osteopontin and Tamm–Horsfall Protein [PDF]

Antioxidants
Hydrogen sulfide (H2S) exerts regulatory functions in kidney diseases. However, its protective role against kidney stone formation remains unclear. Here, we demonstrate that hyperoxaluria or oxalate exposure impairs H2S formation, leading to tubular ...
Chien-Lin Lu, Yi-Shiou Tseng, Wen-Bin Wu, Chun-Hou Liao, Ming-Chieh Ma   +4 more
doaj   +2 more sources

The Long Pentraxin PTX3 Is an Endogenous Inhibitor of Hyperoxaluria-Related Nephrocalcinosis and Chronic Kidney Disease [PDF]

Frontiers in Immunology, 2018
The long pentraxin 3 (PTX3) exerts a variety of regulatory functions in acute and chronic tissue inflammation. In particular, PTX3 acts as an opsonin for a variety of pathogens and endogenous particles.
Julian A. Marschner, Shrikant R. Mulay, Stefanie Steiger, Lidia Anguiano, Zhibo Zhao, Peter Boor, Khosrow Rahimi, Antonio Inforzato, Antonio Inforzato, Cecilia Garlanda, Cecilia Garlanda, Alberto Mantovani, Alberto Mantovani, Hans-Joachim Anders   +13 more
doaj   +2 more sources

Homozygous GRHPR C.494G>A mutation is deleterious that causes early onset of nephrolithiasis in West Bengal, India

Frontiers in Molecular Biosciences, 2022
Pediatric nephrolithiasis (NL) or Kidney stone disease (KSD) is an untethered topic in Asian population. In Western countries, the annual incidence of paediatric NL is around 6–10%.
Arindam Chatterjee, Kunal Sarkar, Sarbashri Bank, Sudakshina Ghosh, Dilip Kumar Pal, Siddharth Saraf, Dhansagar Wakle, Bidyut Roy, Santanu Chakraborty, Biswabandhu Bankura, Biswabandhu Bankura, Debprasad Chattopadhyay, Debprasad Chattopadhyay, Debprasad Chattopadhyay, Madhusudan Das   +14 more
doaj   +1 more source

The Primary Hyperoxalurias [PDF]

Journal of the American Society of Nephrology, 2001
The primary hyperoxalurias (PHs) are rare disorders of glyoxylate metabolism in which specific hepatic enzyme deficiencies result in overproduction of oxalate. Due to the resulting severe hyperoxaluria, recurrent urolithiasis or progressive nephrocalcinosis are principal manifestations.
M, Marangella, M, Petrarulo, C, Vitale, C, Bagnis, S, Berutti, A, Ramello, A, Amoroso   +6 more
openaire   +4 more sources

Primary Hyperoxaluria Type 1: The First Patient Treated with Lumasiran in Portugal

Revista Portuguesa de Nefrologia e Hipertensão, 2023
Primary hyperoxaluria type 1 is a rare genetic disease caused by mutations in AGXT, leading to an excessive hepatic production of oxalate, resulting in urolithiasis, nephrocalcinosis and chronic kidney disease.
Madalena Almeida Borges, João Martins, Joana Monteiro Dias, Nuno Moreira Fonseca, Telma Francisco, Margarida Abranches   +5 more
doaj   +1 more source

Postbiotics and Kidney Disease

Toxins, 2022
Chronic kidney disease (CKD) is projected to become the fifth global cause of death by 2040 as a result of key shortcomings in the current methods available to diagnose and treat kidney diseases.
Chiara Favero, Laura Giordano, Silvia Maria Mihaila, Rosalinde Masereeuw, Alberto Ortiz, Maria Dolores Sanchez-Niño   +5 more
doaj   +1 more source

Long-term outcome after combined or sequential liver and kidney transplantation in children with infantile and juvenile primary hyperoxaluria type 1

Frontiers in Pediatrics, 2023
IntroductionCombined or sequential liver and kidney transplantation (CLKT/SLKT) restores kidney function and corrects the underlying metabolic defect in children with end-stage kidney disease in primary hyperoxaluria type 1 (PH1).
Sebastian Loos, Markus J. Kemper, Kaja Schmaeschke, Uta Herden, Lutz Fischer, Bernd Hoppe, Tanja Kersnik Levart, Enke Grabhorn, Raphael Schild, Jun Oh, Jun Oh, Jun Oh, Florian Brinkert   +12 more
doaj   +1 more source

Current update and future directions on gut microbiome and nephrolithiasis

Indian Journal of Urology, 2020
The incidence of nephrolithiasis is increasing worldwide. Understanding how gut microbiome influences oxalate homeostasis has the potential to offer new strategies to prevent nephrolithiasis.
Ajay P Sharma, Jeremy Burton, Guido Filler, Sumit Dave   +3 more
doaj   +1 more source

Primary Hyperoxaluria [PDF]

International Journal of Nephrology, 2011
Primary hyperoxalurias (PH) are inborn errors in the metabolism of glyoxylate and oxalate. PH type 1, the most common form, is an autosomal recessive disorder caused by a deficiency of the liver-specific enzyme alanine, glyoxylate aminotransferase (AGT) resulting in overproduction and excessive urinary excretion of oxalate.
Jérôme Harambat, Sonia Fargue, Justine Bacchetta, Cécile Acquaviva, Pierre Cochat   +4 more
openaire   +3 more sources

Cardiac involvement of primary hyperoxaluria accompanied by non-compaction cardiomyopathy and patent ductus arteriosus

Türk Kardiyoloji Derneği Arşivi, 2015
Primary hyperoxaluria is a rare hereditary metabolic disorder resulting in accumulation of calcium oxalate in visceral organs, including the heart. We report a 19-year-old male with non- compaction cardiomyopathy combined with patent ductus arteriosus ...
Nurcan Arat, Murat Akyıldız, Gürkan Tellioğlu, Yaman Tokat   +3 more
doaj   +1 more source