Results 71 to 80 of about 18,942 (235)

AZP-531, an unacylated ghrelin analog, improves food-related behavior in patients with Prader-Willi syndrome: A randomized placebo-controlled trial. [PDF]

PLoS ONE, 2018
Prader-Willi syndrome (PWS) is characterized by early-onset hyperphagia and increased circulating levels of the orexigenic Acylated Ghrelin (AG) hormone with a relative deficit of Unacylated Ghrelin (UAG).
Soraya Allas, Assumpta Caixàs, Christine Poitou, Muriel Coupaye, Denise Thuilleaux, Françoise Lorenzini, Gwenaëlle Diene, Antonino Crinò, Frédéric Illouz, Graziano Grugni, Diane Potvin, Sarah Bocchini, Thomas Delale, Thierry Abribat, Maithé Tauber   +14 more
doaj   +1 more source

USP34 Haploinsufficiency as a Cause of Neurodevelopmental Phenotypes

Clinical Genetics, EarlyView.
Heterozygous loss‐of‐function variants in USP34 cause a novel neurodevelopmental disorder characterized by global developmental delay, speech impairment, autism, hypotonia, craniofacial dysmorphism, and distal limb anomalies. Disrupted Wnt/β‐catenin signaling via reduced Axin stabilization refines gene‐specific contributions within 2p15p16.1 ...
Helena Wigoda, Amjad Khan, Bryce A. Mendelsohn, Noriko Miyake, Nobuhiko Okamoto, Naomichi Matsumoto, Patricia J. C. Knijnenburg, Johanna M. van Hagen, Jiddeke van de Kamp, Quinten Waisfisz, Bryn D. Webb   +10 more
wiley   +1 more source

Ghrelin Causes Hyperphagia and Obesity in Rats [PDF]

Diabetes, 2001
Ghrelin, a circulating growth hormone–releasing peptide derived from the stomach, stimulates food intake. The lowest systemically effective orexigenic dose of ghrelin was investigated and the resulting plasma ghrelin concentration was compared with that during fasting.
Wren, AM, Small, CJ, Abbott, CR, Dhillo, WS, Seal, LJ, Cohen, MA, Batterham, RL, Taheri, S, Stanley, SA, Ghatei, MA, Bloom, SR   +10 more
openaire   +3 more sources

Unilateral Temporal Lobe Damage and the Partial Kluver–Bucy Syndrome

Behavioural Neurology, 1995
The characteristic behavioural constellation of Kluver–Bucy syndrome is believed to be diagnostic of bilateral temporal lobe damage, even in the partial syndrome.
G. D. L. Bates, S. G. Sturman
doaj   +1 more source

Brain Serotonin Transporter Is Elevated in Obesity: Bayesian and Frequentist Meta‐Analyses

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims The brain plays a critical role in controlling energy balance. Previous studies have mainly focused on dopaminergic mechanisms, whereas much less attention has been paid to serotonin during the emergence of overweight and obesity. Therefore, this study investigated the association between serotonin transporter (SERT) availability and ...
Kyoungjune Pak
wiley   +1 more source

Variation in energetic balance among free-ranging polar bears during the spring mating and foraging season

Arctic Science
Large carnivores are capable of consuming substantial biomasses that can significantly alter their body mass and condition over short periods. Here we examine the intra-seasonal variation of polar bear (Ursus maritimus Phipps, 1774) body mass, energy ...
Anthony M. Pagano, Stephen N. Atkinson, Louise C. Archer   +2 more
doaj   +1 more source

Type of diet modulates the metabolic response to sleep deprivation in rats

Nutrition & Metabolism, 2011
Background Evidence suggests that sleep loss is associated with an increased risk of obesity and diabetes; however, animal models have failed to produce weight gain under sleep deprivation (SD). Previous studies have suggested that this discrepancy could
Martins Paulo JF, Fernandes Leandro, de Oliveira Allan C, Tufik Sergio, D'Almeida Vânia   +4 more
doaj   +1 more source

Hyperphagia in the Insulin-Treated Rat

Experimental Biology and Medicine, 1968
SummaryProtamine zinc insulin (PZI) was administered daily to male rats by subcutaneous injection (2 units/100 gm of body weight) and comparisons were made with saline-injected control animals. As a consequence of PZI administration, the following observations were made: hyperphagia, increased body weight gain, increased lipogenesis from acetate-1-14C ...
K K, May, J R, Beaton
openaire   +2 more sources

Medication Trials for Hyperphagia and Food-Related Behaviors in Prader–Willi Syndrome

Diseases, 2015
Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by the absence of paternally expressed, imprinted genes on chromosome 15q11-13. Individuals with PWS characteristically have poor feeding and lack of appetite in infancy, followed by the
Jennifer L. Miller, Theresa V. Strong, Janalee Heinemann   +2 more
doaj   +1 more source

One Week Exposure to a Somatostatin Receptor 2 Antagonist (SSTR2a) Enhances Glucagon Counterregulation to Insulin‐Induced Hypoglycaemia and Does Not Worsen Glycemia in a Male Rat Model of Insulin‐Requiring Type 2 Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Administration of a somatostatin receptor 2 antagonist (SSTR2a) increases glucagon responsiveness to hypoglycaemia in insulin‐treated type 2 diabetes (T2D), but the durability of this effect and the impact of repeated SSTR2a dosing on overall glycaemia in T2D are unclear.
Ninoschka C. D'Souza, Emily G. Hoffman, Sara C. Atherley, Sabrina Champsi, Nadia Aleali, Richard T. Liggins, Owen Chan, Michael C. Riddell   +7 more
wiley   +1 more source