METABOLIC EFFECTS OF HYPERPHAGIA IN THE HYPOTHALAMIC-HYPERPHAGIC RAT
, 1966 Metabolic effects of hyperphagia have been investigated in male rats in which hyperphagia was induced by bilateral, electrolytic lesions in the region of the ventromedial nuclei of the hypothalamus.
K. K. May, J. R. Beaton
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Effectiveness and Safety of Setmelanotide in a Patient With a Heterozygous PCSK1 Deficiency
Obesity, EarlyView.ABSTRACT Setmelanotide, a melanocortin 4 receptor (MC4R) agonist, is a promising pharmacological treatment option for people with rare monogenic obesity conditions affecting the leptin‐melanocortin signaling pathway, including proprotein convertase subtilisin/kexin type 1 (PCSK1) gene mutations.
Ellina Lytvyak +2 more
wiley +1 more source
A questionnaire-based survey on hyperphagia in individuals with Prader–Willi syndrome in Japan
Endocrine JournalPrader–Willi syndrome (PWS) is associated with increased mortality, primarily due to complications from hyperphagia-associated obesity. Clinical trials investigating anti-hyperphagic medications are currently underway.
Makiko Tachibana +9 more
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Pediatric Investigation, EarlyView.Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil +2 more
wiley +1 more source
Evidence Supporting a Role for Constitutive Ghrelin Receptor Signaling in Fasting-Induced Hyperphagia in Male Mice [PDF]
, 2022 Ghrelin is a potent orexigenic peptide hormone that acts through the growth hormone secretagogue receptor (GHSR), a G protein-coupled receptor highly expressed in the hypothalamus.
Epelbaum, Jacques +10 more
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Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
wiley +1 more source
Two Stimuli of Hyperphagia: High Fat Diet and Weight Regain
, 2021 : As obesity continues to grow across the world, better understanding of the disease, treatments, and outcomes becomes increasingly important. Animal models used to study these aspects of obesity have 3 phases: experimental (EXP), caloric restriction (CR)
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In adults with Prader–Willi syndrome, elevated ghrelin levels are more consistent with hyperphagia than high PYY and GLP-1 levels [PDF]
, 2011 \ud \ud Objective\ud \ud Prader–Willi syndrome (PWS) is a leading genetic cause of obesity, characterized by\ud hyperphagia, endocrine and developmental disorders.
Purtell, Louise +25 more
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British Journal of Pharmacology, EarlyView.Background and Purpose Obesity involves profound disruptions in neuronal circuits, neuroendocrine communication and the endocannabinoid system. While global blockade of cannabinoid CB1 receptors improves metabolism, its clinical use is limited by neuropsychiatric side effects.
Oriane Onimus +7 more
wiley +1 more source
Two patients with chromosome 22q11.2 deletion presenting with childhood obesity and hyperphagia [PDF]
, 2016 Chromosome 22q11.2 deletion syndrome is a clinically heterogeneous condition of intellectual disability, parathyroid and thyroid hypoplasia, palatal abnormalities, cardiac malformations and psychiatric symptoms.
Bassett, John +4 more
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