Results 41 to 50 of about 20,403 (220)

Glucocorticoid-Induced Fatty Liver Disease

Diabetes, Metabolic Syndrome and Obesity, 2020
Leili Rahimi,1 Aman Rajpal,1,2 Faramarz Ismail-Beigi1,2 1Department of Medicine, Case Western Reserve University, University Hospitals Cleveland Medical Center, Cleveland, OH, USA; 2Cleveland VA Medical Center, Cleveland, OH, USACorrespondence: Faramarz ...
Rahimi L, Rajpal A, Ismail-Beigi F
doaj  

A randomized pilot efficacy and safety trial of diazoxide choline controlled-release in patients with Prader-Willi syndrome.

PLoS ONE, 2019
INTRODUCTION:Prader-Willi syndrome (PWS) is a complex genetic condition characterized by hyperphagia, hypotonia, low muscle mass, excess body fat, developmental delays, intellectual disability, behavioral problems, and growth hormone deficiency.
Virginia Kimonis, Abhilasha Surampalli, Marie Wencel, June-Anne Gold, Neil M Cowen   +4 more
doaj   +1 more source

Heterozygous Genetic Variants in Autosomal Recessive Genes of the Leptin-Melanocortin Signalling Pathway Are Associated With the Development of Childhood Obesity

Frontiers in Endocrinology, 2022
Monogenic obesity is a severe, genetically determined disorder that affects up to 1/1000 newborns. Recent reports on potential new therapeutics and innovative clinical approaches have highlighted the need for early identification of individuals with rare
Robert Šket, Primož Kotnik, Primož Kotnik, Barbara Jenko Bizjan, Valentina Kocen, Matej Mlinarič, Tine Tesovnik, Maruša Debeljak, Maruša Debeljak, Tadej Battelino, Tadej Battelino, Jernej Kovač, Jernej Kovač   +12 more
doaj   +1 more source

Patients With Atypical Symptoms of Depression Respond Better to Lithium Augmentation Than Patients Without Atypical Symptoms

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction Understanding the differences in treatment response between subtypes of major depressive disorder (MDD) may help to prevent lengthy trial‐and‐error processes by identifying effective treatment options. The aim of the study was to investigate the impact of atypical features of MDD (MDD‐A) on the response to lithium augmentation (LA)
Hannah Buchbauer, Mazda Adli, Peter Schlattmann, Maximilian Berger, Tom Bschor, Thomas Stamm, Joachim Behr, Roland Ricken, Pichit Buspavanich   +8 more
wiley   +1 more source

Hyperphagia change from baseline to the end of Open-Label Treatment Overall, High Dose and/or moderate to severe hyperphagia.

, 2019
Hyperphagia change from baseline to the end of Open-Label Treatment Overall, High Dose and/or moderate to severe hyperphagia.
Virginia Kimonis (7418696), Marie Wencel (7418702), Neil M. Cowen (7418705), Abhilasha Surampalli (7418699), June-Anne Gold (6413294)   +4 more
core   +1 more source

Emerging Insights into the Role of BDNF on Health and Disease in Periphery

Biomolecules
Brain-derived neurotrophic factor (BDNF) is a growth factor that promotes the survival and growth of developing neurons. It also enhances circuit formation to synaptic transmission for mature neurons in the brain.
Mayuko Ichimura-Shimizu, Khuleshwari Kurrey, Misaki Miyata, Takuya Dezawa, Koichi Tsuneyama, Masami Kojima   +5 more
doaj   +1 more source

Food reward, hyperphagia, and obesity

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2011
Given the unabated obesity problem, there is increasing appreciation of expressions like “my eyes are bigger than my stomach,” and recent studies in rodents and humans suggest that dysregulated brain reward pathways may be contributing not only to drug addiction but also to increased intake of palatable foods and ultimately obesity.
Hans-Rudolf, Berthoud, Natalie R, Lenard, Andrew C, Shin   +2 more
openaire   +3 more sources

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Hyperphagia in male melanocortin 4 receptor deficient mice promotes growth independently of growth hormone

, 2016
Key points: Loss of function of the melanocortin 4 receptor (MC4R) results in hyperphagia, obesity and increased growth. Despite knowing that MC4Rs control food intake, we are yet to understand why defects in the function of the MC4R receptor contribute ...
Cowley, M., Tan, HY, Veldhuis, JD, Steyn, F. J., Cowley, M, Huang, L., Huang, L, Chen, C, Tan, H. Y., Steyn, FJ, Veldhuis, J. D., Chen, C.   +11 more
core   +1 more source

Unilateral Temporal Lobe Damage and the Partial Kluver–Bucy Syndrome

Behavioural Neurology, 1995
The characteristic behavioural constellation of Kluver–Bucy syndrome is believed to be diagnostic of bilateral temporal lobe damage, even in the partial syndrome.
G. D. L. Bates, S. G. Sturman
doaj   +1 more source