Results 21 to 30 of about 18,942 (235)

Setmelanotide – from genes to targeted therapy in some rare forms of obesity [PDF]

Farmacja Polska, 2021
Obesity is a serious public health concern. It significantly affects an individual’s quality of life and is associated with an increased risk of developing other conditions, including diabetes, hypertension, and cardiovascular complications.
Dawid Frączkowski
doaj   +1 more source

Fasting inhibits excitatory synaptic input on paraventricular oxytocin neurons via neuropeptide Y and Y1 receptor, inducing rebound hyperphagia, and weight gain

Frontiers in Nutrition, 2022
Fasting with varying intensities is used to treat obesity-related diseases. Re-feeding after fasting exhibits hyperphagia and often rebound weight gain. However, the mechanisms underlying the hyperphagia and rebound remain elusive. Here we show that 24 h
Lei Wang, Lei Wang, Lei Wang, Lei Wang, Shigetomo Suyama, Shigetomo Suyama, Samantha A. Lee, Samantha A. Lee, Yoichi Ueta, Yutaka Seino, Geoffrey W. G. Sharp, Toshihiko Yada, Toshihiko Yada, Toshihiko Yada, Toshihiko Yada   +14 more
doaj   +1 more source

Measuring Meaningful Benefit-Risk Tradeoffs to Promote Patient-Focused Drug Development in Prader-Willi Syndrome: A Discrete-Choice Experiment

MDM Policy & Practice, 2021
Background. Prader-Willi syndrome (PWS) is a rare neurodevelopmental disorder causing quality of life impairments such as insatiable hunger (hyperphagia) and obesity.
Jui-Hua Tsai, Norah L. Crossnohere, Theresa Strong, John F. P. Bridges   +3 more
doaj   +1 more source

Burden of hyperphagia and obesity in Bardet–Biedl syndrome: a multicountry survey

Orphanet Journal of Rare Diseases, 2023
Background Signs and symptoms of Bardet–Biedl syndrome (BBS) occur during early childhood, progress over time, and place substantial, multifaceted burden on patients and their caregivers. Hyperphagia may be a contributing factor to early-onset obesity in
Elizabeth Forsythe, Usha G. Mallya, Min Yang, Caroline Huber, Mary Lynn Cala, Alexandra Greatsinger, Ella Hagopian, Jeremy Pomeroy, Andrea M. Haqq   +8 more
doaj   +1 more source

Hyperphagia in intestinal disease [PDF]

Gut, 1974
Six patients with hyperphagia (ingestion of 5-11 000 Kcals/day) associated with severe malabsorption and steatorrhoea are described. The cause of the malabsorption was coeliac disease in three patients, Crohn's disease with ileal resection in two, and carcinoma of the pancreas in one patient.
R J, Hall, B, Creamer
openaire   +2 more sources

Investigating Disordered Eating Behaviours Among Individuals Living With Neurodegenerative Disease: A Scoping Review. [PDF]

J Hum Nutr Diet
ABSTRACT Aim Neurodegenerative diseases and disordered eating have become rapidly expanding areas of research. However, research addressing the relationship between the two is lacking. Methods A scoping review guided by the Joanna Briggs Institute methodological framework was completed to synthesise the evidence related to disordered eating behaviours ...
Buttifant E, Allogmanny S, Probst Y.
europepmc   +2 more sources

Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia [PDF]

, 2023
Antipsychotic (AP) drugs are efficacious treatments for various psychiatric disorders, but excessive weight gain and subsequent development of metabolic disease remain serious side effects of their use.
Libster, Avraham, Osborn, Olivia, Avraham Libster, Francesca Telese, Xu, Baijie, Zhang, Dinghong, Zhang, Zhi, Montilla-Perez, Patricia, Liu, Chen, Chen Liu, Patricia Montilla-Perez, Aisha Nur, Stephanie M. Correa, Dinghong Zhang, Olivia Osborn, Zhi Zhang, Correa, Stephanie M, Rizaldy C. Zapata, Porcu, Alessandra, Nur, Aisha, Zapata, Rizaldy C, Telese, Francesca, Baijie Xu, Alessandra Porcu   +23 more
core   +1 more source

Development and validation of the Pediatric-Youth Hyperphagia Assessment for Prader-Willi syndrome [PDF]

Epidemiology and Health, 2022
OBJECTIVES Hyperphagia is a highly stressful, life-threatening feature of Prader-Willi syndrome (PWS). It is important to assess this complex behavior accurately over time.
Sung Yoon Cho, Danbee Kang, Minji Im, Aram Yang, Min-Sun Kim, Jiyeon Kim, Eu-Seon Noh, Eun Kyung Kwon, Eujin Choi, Sunju Han, Young Ah Park, Min Jung Kwak, Youngha Kim, Juhee Cho, Dong-Kyu Jin   +14 more
doaj   +1 more source

Kleine − Levin syndrome: An ayurvedic perspective

Indian Journal of Ayurveda and Integrative Medicine KLEU, 2022
Kleine − Levin syndrome (KLS), also known as sleeping beauty syndrome, is characterized by the classic triad of hypersomnia, hyperphagia, and hypersexuality. It is an intriguing and severe disease with no clear etiology or management.
Prasad Mamidi, Kshama Gupta
doaj   +1 more source

Hyperinsulinemia is a probable trigger for weight gain and hyperphagia in individuals with Prader‐Willi syndrome

Obesity Science & Practice, 2023
Objective Prader‐Willi syndrome (PWS) is the most frequently diagnosed genetic cause of early childhood obesity. Individuals with PWS typically progress through 7 different nutritional phases during their lifetime. The main objective of this study was to
Frederick A. Kweh, Carlos R. Sulsona, Jennifer L. Miller, Daniel J. Driscoll   +3 more
doaj   +1 more source