Results 11 to 20 of about 26,081 (268)

Hyperphagia in Bardet–Biedl syndrome: Pathophysiology, burden, and management [PDF]

Obesity Reviews
Bardet–Biedl syndrome (BBS) is a rare, genetically heterogeneous, and highly pleiotropic autosomal recessive ciliopathy. Patients typically present with early loss of vision, hyperphagia, severe obesity, learning difficulties, and renal dysfunction.
Metin Cetiner, Philip Beales, Ashley Shoemaker   +2 more
exaly   +6 more sources

A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia [PDF]

Nature Communications, 2018
The molecular pathway(s) driving antipsychotics (AP) induced hyperphagia remains unclear. A novel C. elegans system is used here to screen for FDA approved drugs that selectively suppresses this response, unraveling potential molecular mediators ...
Anabel Perez-Gomez, Maria Carretero, Natalie Weber, Veronika Peterka, Alan To, Viktoriya Titova, Gregory Solis, Olivia Osborn, Michael Petrascheck   +8 more
doaj   +4 more sources

Burden of hyperphagia and obesity in Bardet–Biedl syndrome: a multicountry survey

Orphanet Journal of Rare Diseases, 2023
Background Signs and symptoms of Bardet–Biedl syndrome (BBS) occur during early childhood, progress over time, and place substantial, multifaceted burden on patients and their caregivers. Hyperphagia may be a contributing factor to early-onset obesity in
Elizabeth Forsythe, Usha G. Mallya, Min Yang, Caroline Huber, Mary Lynn Cala, Alexandra Greatsinger, Ella Hagopian, Jeremy Pomeroy, Andrea M. Haqq   +8 more
doaj   +2 more sources

Health state utilities associated with hyperphagia: Data for use in cost‐utility models [PDF]

Obesity Science & Practice, 2023
Objective Rare genetic diseases of obesity typically present with hyperphagia, a pathologic desire to consume food. Cost‐utility models assessing the value of treatments for these rare diseases will require health state utilities representing hyperphagia.
Timothy A. Howell, Louis S. Matza, Usha G. Mallya, Anthony P. Goldstone, W. Scott Butsch, Ethan Lazarus   +5 more
doaj   +2 more sources

Hyperphagia in craniopharyngioma- a real-world study from the international hypothalamic-pituitary brain tumors patient registry [PDF]

Scientific Reports
We previously showed that hyperphagia affects quality of life of craniopharyngioma (CP) survivors. Characteristics of hyperphagia are unknown. This study aimed to characterize and quantify hyperphagia in CP survivors with and without hypothalamic obesity
Nathalie Kayadjanian, Eugenie A. Hsu, Amy M. Wood, Dean S. Carson   +3 more
doaj   +2 more sources

Cold-induced hyperphagia requires AgRP neuron activation in mice

eLife, 2020
To maintain energy homeostasis during cold exposure, the increased energy demands of thermogenesis must be counterbalanced by increased energy intake.
Jennifer D Deem, Chelsea L Faber, Christian Pedersen, Bao Anh Phan, Sarah A Larsen, Kayoko Ogimoto, Jarrell T Nelson, Vincent Damian, Megan A Tran, Richard D Palmiter, Karl J Kaiyala, Jarrad M Scarlett, Michael R Bruchas, Michael W Schwartz, Gregory J Morton   +14 more
doaj   +2 more sources

Hyperphagia: Current concepts and future directions proceedings of the 2nd international conference on hyperphagia [PDF]

Obesity, 2014
ObjectiveHyperphagia is a central feature of inherited disorders (e.g., Prader–Willi Syndrome) in which obesity is a primary phenotypic component. Hyperphagia may also contribute to obesity as observed in the general population, thus raising the potential importance of common underlying mechanisms and treatments.
Steven B, Heymsfield, Nicole M, Avena, Leslie, Baier, Phillip, Brantley, George A, Bray, Lisa C, Burnett, Merlin G, Butler, Daniel J, Driscoll, Dieter, Egli, Joel, Elmquist, Janice L, Forster, Anthony P, Goldstone, Linda M, Gourash, Frank L, Greenway, Joan C, Han, James G, Kane, Rudolph L, Leibel, Ruth J F, Loos, Ann O, Scheimann, Christian L, Roth, Randy J, Seeley, Val, Sheffield, Maïthé, Tauber, Christian, Vaisse, Liheng, Wang, Robert A, Waterland, Rachel, Wevrick, Jack A, Yanovski, Andrew R, Zinn   +28 more
openaire   +4 more sources

The Hyperphagia Questionnaire: Insights From a Multicentric Validation Study in Individuals With Prader Willi Syndrome [PDF]

Frontiers in Pediatrics, 2022
Background/ObjectivesThe present study aimed to validate the Italian version of the Hyperphagia Questionnaire (HQ), a 11-items questionnaire developed to assess hyperphagia in individuals with Prader-Willi syndrome (PWS).
Maria Rosaria Licenziati, Dario Bacchini, Antonino Crinò, Graziano Grugni, Danilo Fintini, Sara Osimani, Letizia Ragusa, Michele Sacco, Lorenzo Iughetti, Luisa De Sanctis, Adriana Franzese, Malgorzata Gabriela Wasniewska, Maria Felicia Faienza, Maurizio Delvecchio, Concetta Esposito, Giuliana Valerio   +15 more
doaj   +3 more sources

Hyperphagia and obesity

Ожирение и метаболизм, 2013
Since ancient times, mankind is faced with the problem of obesity, caused by mismatch between energy intake and energy use. In recent decades, both women and men are involved in obesity epidemic, the occurrence of which can be attributed to the increased
T O Yalochkina, E A Pigarova
doaj   +2 more sources

Involvement of inflammatory gene expression pathways in depressed patients with hyperphagia [PDF]

Translational Psychiatry, 2019
The pathophysiology of major depressive disorder (MDD) is highly heterogeneous. Previous evidence at the DNA level as well as on the serum protein level suggests that the role of inflammation in MDD pathology is stronger in patients with hyperphagia ...
H. de Kluiver, R. Jansen, Y. Milaneschi, B. Penninx   +3 more
semanticscholar   +2 more sources