Results 101 to 110 of about 546,275 (335)

Fos co-operation with PTEN loss elicits keratoacanthoma not carcinoma due to p53/p21^WAF-induced differentiation triggered by GSK3b inactivation and reduced AKT activity [PDF]

, 2008
To investigate gene synergism in multistage skin carcinogenesis, the RU486-inducible cre/lox system was employed to ablate PTEN function [K14.cre/D5PTENflx] in mouse epidermis expressing activated v-fos [HK1.fos].
Alexander, C.L., Chan, W-C., Greenhalgh, D.A., Quinn, J., Wu, H., Yao, D.   +5 more
core   +1 more source

Biocatalytic Nanoregulators Restore Joint Redox‐Immune Homeostasis in Rheumatoid Arthritis

Advanced Science, EarlyView.
Mesenchymal stem cell‐derived extracellular vesicles (EVs) coat ruthenium‐loaded metal‐organic frameworks (Ru@ZrMOF), creating a targeted therapeutic (Ru@ZrMOF/EVs). This platform scavenges ROS, generates oxygen, and polarizes macrophages from M1 to M2, alleviating inflammation, inhibiting pannus, promoting cartilage repair, and downregulating HIF‐1α ...
Xingheng Wang, Jianbo Huang, Shuwei Zhang, Sujiao Cao, Fangxue Du, Liqiang Zhou, Li Qiu, Yuanjiao Tang   +7 more
wiley   +1 more source

Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues

eLife, 2013
How single cells in a mitotic tissue progressively acquire hallmarks of cancer is poorly understood. We exploited mitotic recombination in developing Drosophila imaginal tissues to analyze the behavior of cells devoid of the tumor suppressor PTEN, a ...
Katarzyna Nowak, Gerhard Seisenbacher, Ernst Hafen, Hugo Stocker   +3 more
doaj   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Malignant transformation in oral epithelial dysplasticlesions: An observational study

Journal of Health Sciences
Introduction: This research study is a comprehensive analysis of cases oral epithelial dysplasia (OED) to oral squamous cell carcinoma (OSCC) over the past decade, with a particular focus on eliciting the frequency of malignant transformation (MT) of ...
Anuhya Jayanthi, Sagar Krishna, Sunitha Carnelio, Vasudeva Guddattu, Spoorti Kulkarni   +4 more
doaj   +1 more source

Supplementation of grazing beef cows during gestation as a strategy to improve skeletal muscle development of the offspring

Animal, 2017
The appropriate supply of nutrients in pregnant cows has been associated with the optimal development of foetal tissues, performance of their progeny and their meat quality. The aim of this study was to evaluate supplementation effects of grazing cows in
D.C. Marquez, M.F. Paulino, L.N. Rennó, F.C. Villadiego, R.M. Ortega, D.S. Moreno, L.S. Martins, D.M. de Almeida, M.P. Gionbelli, M.R. Manso, L.P. Melo, F.H. Moura, M.S. Duarte   +12 more
doaj   +1 more source

Small Molecule Inhibitors of TBK1 Reduce Intimal Hyperplasia in a Model of Rat Carotid Artery Post-Balloon Angioplasty Stenosis [PDF]

, 2022
Erin McIntosh, Erin Driscoll, Cleide Angolano, Christiane Ferran   +3 more
openalex   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Verrucous Hyperplasia : Case report and differential diagnosis

Sultan Qaboos University Medical Journal, 2017
Verrucous hyperplasia (VH) is a rare exophytic oral mucosal lesion which can transform into verrucous carcinoma (VC), its malignant but clinically similar counterpart.
Sonal Grover, Mihir Jha, Bhushan Sharma, Shekhar Kapoor, Kumud Mittal, Nithin K. Parakkat, Anil B. Shivappa, Ravleen Kaur   +7 more
doaj   +1 more source

Correction: Lymph node evaluation for endometrial hyperplasia: a nationwide analysis of minimally invasive hysterectomy in the ambulatory setting [PDF]

, 2023
Koji Matsuo, Katharine M. Ciesielski, Rachel S. Mandelbaum, Matthew W. Lee, Neda Jooya, Lynda D. Roman, Jason D. Wright   +6 more
openalex   +1 more source