Results 91 to 100 of about 129,353 (325)
Advanced Science, 2023 Hyperpolarization techniques increase nuclear spin polarization by more than four orders of magnitude, enabling metabolic MRI. Even though hyperpolarization has shown clear value in clinical studies, the complexity, cost and slowness of current equipment
Luca Nagel +23 more
doaj +1 more source
Widespread depolarization during expiration: A source of respiratory drive? [PDF]
, 2014 Respiration influences various pacemakers and rhythms of the body during inspiration and expiration but the underlying mechanisms are relatively unknown.
Barnes, Vernon A. +3 more
core
Electrophysiological Organization of the Eye of Aplysia [PDF]
, 1969 The eye of Aplysia californica was studied by electrophysiological and histological methods. It has a central spheroidal lens which is surrounded by a retina composed of several thousand receptor cells which are replete with clear vesicles, pigmented ...
Jacklet, Jon W.
core +1 more source
Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis
Advanced Science, EarlyView.ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai +15 more
wiley +1 more source
Mitochondrial membrane potential probes and the proton gradient: a practical usage guide
BioTechniques, 2011 Fluorescent probes for monitoring mitochondrial membrane potential are frequently used for assessing mitochondrial function, particularly in the context of cell fate determination in biological and biomedical research.
Seth W. Perry +4 more
doaj +1 more source
Signal transmission through the dark-adapted retina of the toad (Bufo marinus). Gain, convergence, and signal/noise. [PDF]
, 1990 Responses to light were recorded from rods, horizontal cells, and ganglion cells in dark-adapted toad eyecups. Sensitivity was defined as response amplitude per isomerization per rod for dim flashes covering the excitatory receptive field centers.
Copenhagen, David, Hemilä, S, Reuter, T
core +2 more sources
Science Advances, 2016 More than 10,000-fold enhanced magnetic resonance signals with >20-min signal lifetimes on universal biomolecular markers. Conventional magnetic resonance (MR) faces serious sensitivity limitations which can be overcome by hyperpolarization methods, but ...
T. Theis +10 more
semanticscholar +1 more source
Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy
Advanced Science, EarlyView.Autoantibodies against fibroblast growth factor receptor 3 (FGFR3) are identified as pathogenic drivers of pain in small fiber neuropathy. By binding to sensory neurons in dorsal root ganglia, FGFR3 autoantibodies activate MAPK signaling and induce hyperexcitability and mechanical hypersensitivity, establishing FGFR3 autoantibodies as a therapeutic ...
Lyuba Y. Salih +12 more
wiley +1 more source
The Effects of Serotonin on Functionally Diverse Isolated Lamprey Spinal Cord Neurons [PDF]
, 2002 The experiments reported here showed that application of serotonin (5-hydroxytryptamine, 5-HT) (100 µ M) did not induce any significant current through the membranes of any of the spinal neurons studied (n = 62).
Batueva, I. V. +4 more
core +1 more source
Towards a computational model for stimulation of the Pedunculopontine nucleus [PDF]
, 2009 The pedunculopontine nucleus (PPN) has recently been suggested as a new therapeutic target for deep brain stimulation (DBS) in patients suffering from Parkinson's disease, particularly those with severe gait and postural impairment [1].
Gils, Stephan A. van +3 more
core +4 more sources