Results 101 to 110 of about 129,353 (325)
Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging
Advanced Science, EarlyView.Cell death is important in both the development and treatment of cancer. In this study, it is demonstrated for the first time that a specific measurement of the transmembrane water exchange rate using magnetic resonance imaging can be used as an early marker of cell death in mammalian cells, in animals and in human patients. Abstract Cell death plays a
Athanasia Kaika +22 more
wiley +1 more source
Journal of the American Chemical Society, 2016 Direct NMR hyperpolarization of naturally abundant 15N sites in metronidazole is demonstrated using SABRE-SHEATH (Signal Amplification by Reversible Exchange in SHield Enables Alignment Transfer to Heteronuclei).
D. Barskiy +6 more
semanticscholar +1 more source
Single‐Mitochondrion ATP Profiling Directs Discovery of Targetable OXPHOS Dependency in Cancers
Advanced Science, EarlyView.MitoATP‐nFCM integrates nano‐flow cytometry with fluorogenic probes (ATP/membrane potential) and antibodies to quantify mitochondrial metabolites and protein expression at single‐organelle resolution, exposing oxidative phosphorylation (OXPHOS)‐driven metabolic rewiring in cancers.
Xu Xiao +7 more
wiley +1 more source
SABRE Ir-IMes Catalysis for the Masses
MoleculesThe Signal Amplification By Reversible Exchange (SABRE) technique provides enhancement of Nuclear Magnetic Resonance (NMR) signals up to several orders of magnitude using chemical exchange of a substrate and parahydrogen on an iridium complex. Therefore,
Izabelle Smith +13 more
doaj +1 more source
Simulating Effects of Learning and Lesions with a Model of Intrinsic and Synaptically Gated Responses of Striatal Cholinergic Interneurons [PDF]
, 2006 The giant cholinergic interneurons of the striatum are tonically active neurons (TANs) that respond with characteristic pauses to novel events and to appetitive and aversive conditioned stimuli.
Bullock, Daniel, Tan, Can Ozan
core +1 more source
Advanced Science, EarlyView.Cyclic nucleotide‐gated (CNG) and hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels share substantial sequence and structural similarity but differ markedly in ion conductance and K+ selectivity. Microsecond‐scale atomistic MD simulations qualitatively reproduced the conductance differences observed in single‐channel recordings and ...
Haoran Liu +3 more
wiley +1 more source
Hyperpolarization of Molecular Deuterium
Angewandte Chemie, EarlyView.Hyperpolarized molecular deuterium is generated and detected using a nonhydrogenative SABRE catalyst with nicotinamide. The resonance shows a strongly enhanced partially negative line, substrate‐dependent and sensitive to transient intermediates.
Theresa L. K. Hune +5 more
wiley +2 more sources
TRPV4 Contributes to Resting Membrane Potential in Retinal Müller Cells: Implications in Cell Volume Regulation [PDF]
, 2017 Neural activity alters osmotic gradients favoring cell swelling in retinal Müller cells. This swelling is followed by a regulatory volume decrease (RVD), partially mediated by an efflux of KCl and water. The transient receptor potential channel 4 (TRPV4),
Capurro, Claudia Graciela +7 more
core +1 more source
Light-evoked hyperpolarization and silencing of neurons by conjugated polymers
Scientific Reports, 2016 The ability to control and modulate the action potential firing in neurons represents a powerful tool for neuroscience research and clinical applications.
Paul L. C. Feyen +9 more
semanticscholar +1 more source
Optical hyperpolarization of 13 C nuclear spins in nanodiamond ensembles [PDF]
, 2015 Here we propose and analyse in detail protocols that can achieve rapid hyperpolarization of 13C nuclear spins in randomly oriented ensembles of nanodiamonds at room temperature.
Q. Chen +4 more
semanticscholar +1 more source